Delivery system for an active ingredient
A delivery system and technology for active ingredients, applied in the field of preparing the delivery system, can solve problems such as limited loading of active ingredients
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Embodiment 1
[0117] Preparation of the delivery system of the invention
[0118] All solutions were prepared in ultrapure water unless otherwise stated.
[0119] An aqueous solution of calcium chloride (0.1M) and a 2 wt% aqueous solution of green tea extract (from Naturex) (referred to herein as "GTE") were simultaneously introduced into the first mixing chamber and stirred until homogeneous. Each material was introduced at a flow rate of 2.5 ml / min. Thereafter, the mixture was transferred to a second mixing chamber, into which a combined mixture of disodium hydrogen phosphate aqueous solution (0.08M) and sodium carbonate aqueous solution (0.02M) was introduced at a flow rate of 2.5 ml / min. The prepared solutions were mixed to obtain equimolar amounts of cationic components (Ca 2+ ) and anionic components (PO 4 3- and CO 3 2- ) of the final product. The pH of the solution was 6.6.
[0120] The mixture was filtered under vacuum, washed 3 times with 2 ml of water, and dried at room...
Embodiment 2
[0125] Effect of Excess Cationic Components
[0126] Example 1 was repeated except that the calcium chloride flow rate was increased to 3.5 ml / min, resulting in a ratio of cationic component to anionic component in the encapsulating material of 1.4:1.
[0127] The final powdery product was prepared in the manner described in Example 1 and analyzed by HPLC. Compared with Example 1, it was found that the loading of green tea extract was significantly reduced.
Embodiment 3
[0129] Effect of Excess Anionic Components
[0130] Example 1 was repeated except that the flow rate of the dibasic sodium phosphate / sodium carbonate mixture was increased to 3.5 ml / min, resulting in a cation to anion ratio of 0.7:1.
[0131] The final powdery product was prepared in the manner described in Example 1 and analyzed by HPLC. Compared to the loading of Example 1, an increase in the loading of green tea extract was found to be greater than 35%.
[0132] The above examples demonstrate the clear benefit of an excess of anionic component over an excess of cationic component.
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Abstract
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