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Drug for treating coronary heart disease and extraction process

A technology for coronary heart disease and medicine, applied in the field of medicine for the treatment of coronary heart disease, can solve the problems of low bioavailability, low content of active ingredients, and backward production technology.

Inactive Publication Date: 2011-04-27
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are ordinary compound Danshen tablets and capsules on the market, but the production technology of ordinary tablets and capsules is backward, the content of active ingredients is low, and there is no quality control index. It needs to be taken orally and absorbed through the gastrointestinal tract, and absorbed after the first-pass effect in the liver. Into the blood, low bioavailability, slow absorption. It is not suitable for the first aid needs of patients with angina pectoris

Method used

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  • Drug for treating coronary heart disease and extraction process
  • Drug for treating coronary heart disease and extraction process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] For the preparation of the medicine for treating coronary heart disease, the weight percentages of the active ingredients of the medicine are as follows: Danshen 82.87%, Panax notoginseng 16.21%, and Borneol 0.92%;

[0072] Step 1: Extract 5 times the amount of Danshen with 95% ethanol under reflux for 2 hours, filter, use 3 times the amount of 95% ethanol for the dregs, extract under reflux for 1 hour, filter, use the dregs to extract salvianolic acid B, and concentrate the filtrate to 0.4- 0.5 times the amount of medicinal materials, let it stand, and filter; precipitate and dry to obtain the first part of Tanshinone IIA extract; apply AB-8 macroporous resin to the filtrate, elute with 70% ethanol, collect the eluate, concentrate to 40% alcohol content, and refrigerate Stand still for more than 12 hours, filter, precipitate and dry under reduced pressure to obtain cryptotanshinone extract; continue to elute with 95% ethanol, collect the eluate, concentrate to 80% alcoh...

Embodiment 2

[0077] Embodiment 2 The preparation of the medicine for treating coronary heart disease, each component is composed of the weight percentage of the active ingredients of the medicine based on the crude drug: 19.8% of Danshen, 78.2% of Radix Notoginseng, and 2% of Borneolum;

[0078] Step 1: Extract 2 times the amount of Danshen with 95% ethanol under reflux for 1 hour, filter, use 20 times the amount of 95% ethanol for the dregs, extract under reflux for 1 hour, filter, use the dregs to extract salvianolic acid B, and concentrate the filtrate to 0.4- 0.6 times the amount of medicinal material, let stand, filter; precipitate and dry to obtain the first part of Tanshinone IIA extract; apply AB-8 macroporous resin on the filtrate, elute with 70% ethanol, collect the eluate, concentrate to 20% alcohol content, and refrigerate Stand still for more than 12 hours, filter, precipitate and dry under reduced pressure to obtain cryptotanshinone extract; continue to elute with 95% ethanol,...

Embodiment 3

[0083] The preparation of embodiment 3 compound danshen dripping pills, each component is composed of the weight percent of active ingredient of medicine based on crude drug: 97% of salvia miltiorrhiza, 2% of notoginseng, 1% of borneol,

[0084] Step 1: Extract 2 times the amount of Danshen with 95% ethanol under reflux for 1 hour, filter, use 20 times the amount of 95% ethanol for the dregs, extract under reflux for 10 hours, filter, use the dregs to extract salvianolic acid B, and concentrate the filtrate to 0.2 times Amount of medicinal material, stand still, filter; precipitate and dry to obtain the first part of tanshinone IIA extract; apply AB-8 macroporous resin on the filtrate, elute with 50% ethanol, collect the eluate, concentrate to 40% alcohol content, refrigerate and stand For more than 12 hours, filter, precipitate and dry under reduced pressure to obtain cryptotanshinone extract; continue to elute with 85% ethanol, collect the eluate, concentrate to 65% alcohol c...

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Abstract

The invention relates to a drug for treating coronary heart disease and an extraction process. The extraction method comprises the following steps: extracting tanshinol with alcohol; extracting dregs of salvia; extracting notoginseng with alcohol; and extracting dreg decoction of salvianolic acid and the like. The invention has the following advantages: the process route can realize industrialization and the quality is stable and controllable. Relevant experiments show that the drug has the advantages of high curative effect and product purity, good absorbability, stable quality and novel application compared with the prior art, and meanwhile, the preparation method is simple in process, convenient to operate, low in cost and suitable for industrial production.

Description

technical field [0001] The invention relates to a medicine for treating coronary heart disease, which belongs to the field of traditional Chinese medicine. Background technique [0002] With the improvement of living standards, the aging of the world's population and the rejuvenation of the disease population, cardiovascular and cerebrovascular patients are increasing year by year, and have become the second largest disease that endangers human health. Angina pectoris is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Coronary heart disease angina pectoris refers to angina pectoris caused by myocardial ischemia and hypoxia due to coronary artery sclerosis or spasm, accounting for about 90% of angina pectoris patients. [0003] The current methods of treating angina pectoris mainly focus on dilating blood vessels, reducing blood viscosity, anti-platelet aggregation, and anti-coag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61P9/10A61K31/045
Inventor 刘顺航徐波戚可人刘岩陈红丛德刚赵国辉
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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