Application of acarbose to preparation of medicament or feed for ruminants

A technology for ruminants and acarbose, applied in the field, can solve problems such as shortage, and achieve the effects of preventing rumen acidosis, reducing the production speed, and increasing the pH value of the rumen

Inactive Publication Date: 2011-05-04
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, how to effectively prevent the decrease of rumen pH value and prevent the occurrence of rumen acidosis still lacks specific effective measures

Method used

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  • Application of acarbose to preparation of medicament or feed for ruminants
  • Application of acarbose to preparation of medicament or feed for ruminants
  • Application of acarbose to preparation of medicament or feed for ruminants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Effects of acarbose on goat rumen fermentation and blood biochemical indicators

[0018] Four one-year-old Boer goats weighing about 30±2kg with ruminal fistula were used in a 4×4 Latin square experimental design. The whole test period is 84 days, divided into 4 phases. Each period is 21 days, with an 18-day pre-test period and a 3-day sampling period. The dosage of acarbose in the treatment group was 0.5, 1 and 2 mg / kg.B.W per day, and the control group was fed with no acarbose and fed twice in the morning and evening. The rumen fluid was collected before feeding in the morning, and the rumen pH was measured at the same time.

[0019] The concentration of volatile fatty acids was measured by gas chromatography, the pH value of rumen fluid was measured by acidity meter, the concentration of ammonia nitrogen and lactic acid was measured by colorimetry, and the blood biochemical indicators were measured by kits. The above methods were all conventional methods...

Embodiment 2

[0026] Example 2: Effect of acarbose on in vitro fermentation of goat rumen microorganisms

[0027] Before feeding in the morning, the rumen fluid of Boer goats was collected through rumen fistula, filtered through four layers of gauze and used as the inoculum. The rumen fluid was mixed with the preheated anaerobic microbial culture medium at a ratio of 1:2 to become the culture medium. (The culture medium is composed of trace element A solution, buffer B, buffer C, D solution and reducing agent solution E. Wherein A solution is added CaCl per 100mL distilled water 2 2H 2 O 13.2g, MnCl 2 4H 2 O 10.0g, CoCl 2 ·6H 2 O 1.0g, FeCl 3 ·6H 2 O 8.0g, B solution is 1L distilled water with NH added 4 HCO 3 4.0g, NaHCO 3 35.0g, C solution is 1L distilled water, add Na 2 HPO 4 5.7g, KH 2 PO 4 6.2g, MgSO 4 ·7H 2 O 0.6g, D liquid is 0.1% resazurin solution, E liquid is every 100mL of distilled water adding cysteine ​​hydrochloride 0.625g NaOH 160mg, NaOH 2 S·9H 2O 0.625...

Embodiment 3

[0032] Example 3: The effect of acarbose on the cumulative gas production of goat rumen microorganisms in vitro fermentation

[0033] Before feeding in the morning, the rumen fluid of Boer goats was collected through rumen fistula, filtered through four layers of gauze and used as the inoculum. The rumen fluid was mixed with the preheated anaerobic microbial culture medium at a ratio of 1:2 to become the culture medium. (The culture medium is composed of trace element A solution, buffer B, buffer C, D solution and reducing agent solution E. Wherein A solution is added CaCl per 100mL distilled water 2 2H 2 O 13.2g, MnCl 2 4H 2 O 10.0g, CoCl 2 ·6H 2 O 1.0g, FeCl 3 ·6H 2 O 8.0g, B solution is 1L distilled water with NH added 4 HCO 3 4.0g, NaHCO 3 35.0g, C solution is 1L distilled water, add Na 2 HPO 4 5.7g, KH 2 PO 4 6.2g, MgSO 4 ·7H 2 O 0.6g, D liquid is 0.1% resazurin solution, E liquid is every 100mL of distilled water adding cysteine ​​hydrochloride 0.625g ...

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Abstract

The invention discloses application of acarbose to preparation of a medicament or feed for ruminants, and in particular relates to application to preparation of a medicament or feed for increasing the pH value of a rumen and preventing or treating rumen acidosis of the ruminants. Due to the application of the acarbose, the rumen fermentation mode of a goat is changed; the pH value of the rumen is increased; and blood sugar in blood, cholesterol, triglyceride, blood urea nitrogen and serum total protein are not influenced obviously. In-vitro batched fermentation tests prove that the ph value during in-vitro fermentation is increased obviously and the gas production rate of rumen microorganisms within 24 hours is reduced after the acarbose is added. Due to the application of the acarbose, the rumen pH value of the ruminants can be effectively increased and rumen acidosis can be prevented or treated.

Description

technical field [0001] The invention belongs to the field of animal husbandry, and specifically relates to the application of acarbose in the preparation of ruminant medicine or feed. The invention uses acarbose to increase the rumen pH value, prevent and treat rumen acidosis in ruminants, and is used for In the breeding of ruminants such as goats, sheep, dairy cows, beef cattle, etc., reduce the occurrence of rumen acidosis, promote the health of ruminants, and alleviate the negative impact of rumen acidosis on the production performance of ruminants and the benefits of breeding industry. Background technique [0002] In recent years, with the rapid development of my country's cattle and sheep industry, the scale of cattle and sheep breeding in my country has been increasing, the amount of breeding has continued to increase, and the level of breeding technology has also continued to improve. However, due to the poor quality of the existing roughage in our country, there are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61P39/02A23K1/16A23K1/18A23K20/163A23K50/10
Inventor 毛胜勇朱伟云魏德泳
Owner NANJING AGRICULTURAL UNIVERSITY
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