Medicinal composition for treating hemophilia

A composition and hemophilia technology, applied in the field of medicine, can solve the problems of patients who cannot stand and walk normally, joint deformities, and joint function difficult to return to normal

Inactive Publication Date: 2011-05-18
TIANJIN TIANCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After blood stasis reaches the patient's joint cavity, it will limit the joint's movement and temporarily lose its function. For example, patients often cannot stand and walk normally after knee joint bleeding
It usually takes several weeks for the blood stagnated into the joint cavity to be gradually absorbed, so as to gradually restore function, but if the joint bleeds repeatedly, it can lead to synovitis and arthritis, resulting in joint deformity, making it difficult for the joint function to return to normal. As a result, many people with hemophilia have varying degrees of disability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 20 parts of Rehmannia, 25 parts of Eclipta, 12 parts of Cuscuta, 12 parts of Poria,

[0035] 8 parts of Ligustrum lucidum, 6 parts of Shouwu, 6 parts of Achyranthes bidentata, 15 parts of Agrimony,

[0036] 4 parts of Rehmannia glutinosa.

[0037] Mix the above-mentioned Chinese medicinal materials, heat or percolate twice, combine the two extracts, recover ethanol under reduced pressure to obtain a crude extract, and discard the dregs. The crude extract is adjusted to pH 7-8 with 5% NaOH solution to obtain an alkaline liquid, which is extracted with chloroform (or petroleum ether). Separate the solvent layer, discard it, adjust the pH of the water layer to 2-4 with 5% sulfuric acid, place it, centrifuge, and acidify the precipitate for later use. After drying, 30g (C) is obtained, and the solution is extracted with chloroform (or petroleum ether). The layers were separated, the water layer was concentrated to obtain 86g, the solvent layer was concentrated to obtain a...

Embodiment 2

[0039] 10 parts of Rehmannia, 20 parts of Eclipta, 12 parts of Poria, 6 parts of Rehmannia

[0040] Ligustrum lucidum 6 parts, Shouwu 6 parts, Achyranthes bidentata 10 parts, Agrimony 12 parts, Cuscuta 15 parts.

[0041] Mix the above-mentioned Chinese medicinal materials, heat or percolate twice, combine the two extracts, recover ethanol under reduced pressure to obtain a crude extract, and discard the dregs. Adjust the pH of the crude extract to 7-8 with 5% NaOH solution to obtain an alkaline liquid, filter, discard the precipitate, adjust the pH of the supernatant to 2-4 with 5% sulfuric acid, place it, centrifuge, and acidify Standby, after drying, 34g was obtained. The solution was extracted with ethyl acetate (or n-butanol), separated into layers, the water layer was discarded, and the solvent layer was concentrated to obtain the extract, which was dried to obtain 45g, and mixed with the acidic precipitate to obtain a mixture of 79g. Add 20 parts of starch and 5 parts o...

Embodiment 3

[0043]30 parts of Rehmannia, 25 parts of Eclipta, 15 parts of Cuscuta, 15 parts of Poria, and 5 parts of Achyranthes bidentata

[0044] 8 parts of Ligustrum lucidum, 5 parts of Shouwu, 10 parts of Agrimony, and 6 parts of Rehmannia glutinosa.

[0045] Mix the above-mentioned Chinese medicinal materials, extract twice with 18 times the amount of 1% sodium hydroxide (or sodium carbonate) solution, combine the two extracts, concentrate under reduced pressure to obtain a crude extract, and discard the dregs. Put the crude extract on a silica gel column, elute with chloroform (or ethyl acetate, methanol), collect each part, use magnesium powder-hydrochloric acid for qualitative identification, combine the positive parts, and concentrate under reduced pressure to obtain 30 g of the mixture, which is added to No. Capsules are made into capsules.

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PUM

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Abstract

The invention discloses a medicinal composition for treating hemophilia. The medicinal composition for treating the hemophilia is prepared from the following raw materials in part by weight: 15 to 30 parts of rehmannia root, 15 to 25 parts of yerbadetajo herb, 10 to 15 parts of south dodder seed, 10 to 15 parts of Indian buead, 5 to 8 parts of glossy privet fruit, 5 to 8 parts of prepared tuber fleeceflower root, 5 to 10 parts of twotooth achyranthes root, 10 to 15 parts of hairyvein agrimonia herb and bud and 3 to 6 parts of rehmannia root. The medicinal composition for treating the hemophilia can cool the blood and stop bleeding, can also generate and enrich the blood, treats both the symptoms and diseases, has a two-way adjustment function and a good curative effect on the hemophilia and various hemorrhagic diseases caused by blood heat, can stop bleeding quickly, and obviously increases the average value of procoagulant activity.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating hemophilia. Background technique [0002] Hemophilia (hemophilia) is a group of relatively common hereditary bleeding disorders, with the characteristics of X-linked recessive inheritance. According to the lack of coagulation factors, it can be divided into hemophilia A (hemophilia A, FVIII deficiency) and hemophilia B (hemophilia B, FIX deficiency). In hemophilia A or B, the decrease of FVIII or FIX procoagulant activity leads to thromboplastin generation disorder, prolonged coagulation time, and abnormal bleeding tendency after minor trauma for life. The incidence rate in my country is relatively low, and about 80% of them are hemophilia A, which is characterized by juvenile onset, spontaneous or mild traumatic bleeding, hematoma formation and joint bleeding. Due to the lack of a certain coagulation factor in the patient's blood plas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P7/04
Inventor 张国基
Owner TIANJIN TIANCHENG PHARMA
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