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Application of Tibetan medicine composition to preparation of medicine for treating central neuropathic pains

A central nervous system and composition technology, applied in the field of medicine, can solve the problems of anticonvulsant drugs such as large side effects, harm to human health, and use restrictions, and achieve strong analgesic and therapeutic effects without toxic and side effects

Inactive Publication Date: 2011-05-18
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, the commonly used drugs for the treatment of central neuropathic pain mainly include the following categories: one is analgesics, including opioid analgesics and central non-opioid analgesics, analgesics can effectively relieve pain, but these drugs have Addictive, limited use
The second is antidepressants. Taking antidepressants can help relieve some central nervous pain, especially for patients with obvious emotional reactions and high depression questionnaire scores. Depressants are not universal in the treatment of central neuropathic pain, only for some central neuropathic pain
The third is anticonvulsant drugs, which mainly cause analgesic effect by inhibiting abnormal subcortical synaptic conduction and pathological multi-neuron reflex, but anticonvulsant drugs have relatively large side effects, such as nausea and vomiting, liver and spleen damage , bone marrow suppression, platelet insufficiency, myocardial toxicity, etc., which seriously endanger human health and cannot be taken for a long time
The above two Tibetan medicine compositions have the effects of promoting blood circulation and removing blood stasis, reducing swelling and alleviating pain; at present, the above two Tibetan medicine compositions are only used for the treatment of acute and chronic sprains, rheumatism, and rheumatoid diseases, and have an analgesic effect on peripheral nerves. And do not find the application of above-mentioned Tibetan medicine composition in the preparation treatment central neuropathic pain medicine

Method used

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  • Application of Tibetan medicine composition to preparation of medicine for treating central neuropathic pains

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of powder

[0039] The crude drug of the Tibetan medicine composition that can be used for the treatment of central neuropathic pain of the present invention is: 5 parts by weight of unique taste, 2 parts by weight of Oxytropis, 15 parts by weight of turmeric, 7 parts by weight of Chinese prickly ash, 5 parts by weight of buffalo horn, water Cypress branch 15 parts by weight;

[0040] The specific weight portion of the medicinal materials of Duyiwei, Oxytropis, Turmeric, Zanthoxylum bungeanum, Buffalo Horn and Shuibazhi are selected for use, and the above-mentioned raw materials are made into 1-10 μm ultrafine powder by ultrafine pulverization technology, and then made into a powder.

Embodiment 2

[0042] Preparation of capsules

[0043] The crude drug of the Tibetan medicine composition that can be used for the treatment of central neuropathic pain of the present invention is: 8 parts by weight of unique taste, 3 parts by weight of Oxytropis, 20 parts by weight of turmeric, 10 parts by weight of Zanthoxylum bungeanum, 8 parts by weight of buffalo horn, water 20 parts by weight of cypress branch, 0.5 part by weight of safflower, 0.2 part by weight of borneol, 0.2 part by weight of camphor;

[0044] Grinding the Zanthoxylum bungeanum and buffalo horn in specific parts by weight into fine powders of 0.01-200 μm for use; mixing the other specific parts by weight of Duyiwei, Oxytropis, Turmeric, Water Cypress Branch, and Safflower medicinal materials, and pulverizing them, Decoct it with water 10 times the weight of the material, decoct and extract 3 times, each time for 1 hour, then collect and combine the above three extracts, and concentrate the extract into an extract wi...

Embodiment 3

[0046] Preparation of granules

[0047] The crude drug of the Tibetan medicine composition that can be used for the treatment of central neuropathic pain of the present invention is:

[0048] 9.1 parts by weight of unique taste, 4.5 parts by weight of Oxytropis, 40.9 parts by weight of turmeric, 13.6 parts by weight of Chinese prickly ash, 9.1 parts by weight of buffalo horn, 22.7 parts by weight of Cypress branch, 1.8 parts by weight of safflower, 2.0 parts by weight of borneol, 2.0 parts by weight of camphor ;

[0049] Grinding the above specific parts by weight of Zanthoxylum bungeanum and buffalo horn into fine powders of 0.01-200 μm for use, for the other specific parts by weight of Duyiwei, Oxytropis, Turmeric, Shuibazhi, Red The flower medicinal materials are mixed and crushed into coarse powder, and the above mixed medicinal materials are extracted with 75% ethanol which is 8 times the weight of the above mixed medicinal materials for 3 times, each time for 1.5h, and ...

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Abstract

The invention discloses application of a Tibetan medicine composition to the preparation of a medicine for treating central neuropathic pains. The Tibetan medicine composition consists of the following raw material medicines in part by weight: 5 to 15 parts of lamiophlomis, 2 to 10 parts of whin, 15 to 60 parts of turmeric, 7 to 20 parts of pricklyash peel, 5 to 15 parts of buffalo horn, 15 to 40 parts of myricaria, 0.1 to 2.5 parts of safflower, 0.1 to 5 parts of borneol and 0.1 to 5 parts of camphor. Further researches on the pharmacology of the conventional Tibetan medicine composition prove that the Tibetan medicine composition has good effect of relieving the central neuropathic pains; in addition, the Tibetan medicine composition is prepared from purely natural wild medicinal materials produced in Tibet plateau, is not added with any chemically synthesized stabilizer, does not have any toxic or side effect on human bodies, is safe and effective, and is suitable for various people and suitable for treating various central neuropathic pains.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a Tibetan medicine composition in the preparation of medicines for treating central neuropathic pain. Background technique [0002] Central neuropathic pain is a common clinical disease, which refers to the pain caused by the disease of the central nervous system. After factors, comes one of the most intractable pain syndromes. According to the classification of pain, it can be classified as neuropathic pain, neuropathic pain or systemic pain. In rehabilitation medicine, it is generally classified as chronic pain, also known as "central neuropathic pain syndrome". Anatomically divided into pain after spinal cord injury and pain after stroke, the symptoms and signs of the two may be completely different, and the most common causes are vascular disease, trauma and demyelinating disease. [0003] Patients with central neuropathic pain often have obvious clinical manifest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P25/04A61K31/045A61K31/125A61K35/32
Inventor 白玛卓玛张樱山张国霞陈丽娟张琼文
Owner TIBET QIZHENG TIBETAN MEDICINE
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