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Microfluidic radiosynthesis system for positron emission tomography biomarkers

A technology of radiosynthesis and radioactive labeling, applied in chemical/physical/physical chemical processes, chemical/physical/physical chemical reactors, microstructure devices without moving elements, etc., can solve inefficient, uneconomical, and expensive Problems such as expensive reagents

Inactive Publication Date: 2011-06-01
SIEMENS MEDICAL SOLUTIONS USA INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, since many commercial automated systems are built for macroscopic synthesis, the process requires the consumption of large amounts of expensive reagents (such as precursors or Kryptofix 2.2.2), which is inefficient and ineffective for both clinical and research purposes. Economy

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  • Microfluidic radiosynthesis system for positron emission tomography biomarkers
  • Microfluidic radiosynthesis system for positron emission tomography biomarkers
  • Microfluidic radiosynthesis system for positron emission tomography biomarkers

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Embodiment Construction

[0071] In the following description, for purposes of explanation and not limitation, details and descriptions are set forth in order to provide a thorough understanding of the present invention. However, it will be apparent to those skilled in the art that the present invention may be practiced in other embodiments that depart from these details and descriptions.

[0072] US Patent Application Serial No. 11 / 895,636, filed August 23, 2007, entitled "System for Purification and Analysis of Radiochemical Products Yielded by Microfluidic Synthesis Devices," is hereby incorporated by reference in its entirety.

[0073]In general, conventional automated synthesizers for synthesizing radiopharmaceuticals are inefficient, and highly efficient microfluidic reactors identified so far require manual operation. Various embodiments of the invention allow for automated operation of microfluidic reactors. Previous microfluidic reactors have been operated inside fixed leaded hot chambers thr...

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Abstract

Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

Description

[0001] related application [0002] This application claims U.S. Provisional Application No. 60 / 923,086 filed April 12, 2007, U.S. Provisional Application No. 60 / 923,407 filed April 13, 2007, U.S. Non-Provisional Application No. .11 / 895,636 and the priority of US Provisional Application No. 61 / 010,822 filed January 11, 2008, the contents of each of which are hereby incorporated by reference in their entirety. technical field [0003] The present invention relates generally to microfluidic devices and related technologies, and to chemical processes using such devices. More specifically, the present invention relates to the fully automated synthesis of radioactive compounds for imaging, eg, by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, embodiments of the invention relate to automated, self-contained microfluidic instruments (such as probes for PET) for multi-step chemical synthesis of radiopharmaceuticals and methods of using suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00
CPCB01J2219/00783B01J2219/00833B01J2219/00907B01J2219/00959C07B59/00B01J2219/00963B01J2219/00952B01J2219/00831B01J2219/00826B01J2219/0086B01J2219/00909B01J2219/00961B01J2219/0099B01J19/0093B01J2219/00873B01J2219/00986B01J2219/00891B01J19/00B81B1/00
Inventor A·M·埃利扎罗夫C·E·鲍尔张建中H·科尔布R·M·范达姆L·迪纳S·福德R·米拉黑
Owner SIEMENS MEDICAL SOLUTIONS USA INC
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