Compound pharmaceutical composition for improving oral bioavailability of taxol and application thereof

A technology for paclitaxel and a composition is applied in the field of compound pharmaceutical compositions for improving oral bioavailability of paclitaxel, which can solve the problems of unknown and cytotoxicity of human bone marrow cells, achieve clear action mechanism, improve oral bioavailability, and improve oral bioavailability. The effect of antitumor activity

Inactive Publication Date: 2011-06-15
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The three major metabolites are not cytotoxic to tumor cells, but are cytotoxic to human bone marrow cells (HenningssonA, KarlssonMO, ViganoL, GianniL, VerweijJ, SparreboomA.Mechanism-basedpharmacokineticmodelforpaclitax

Method used

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  • Compound pharmaceutical composition for improving oral bioavailability of taxol and application thereof
  • Compound pharmaceutical composition for improving oral bioavailability of taxol and application thereof
  • Compound pharmaceutical composition for improving oral bioavailability of taxol and application thereof

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Abstract

The invention discloses a compound pharmaceutical composition for improving oral bioavailability of taxol and application thereof. The invention also discloses a pharmaceutical composition containing the compound pharmaceutical composition and a taxol monomeric compound. The compound pharmaceutical composition provided by the invention can be used for improving the oral bioavailability of the taxol and can improve the anticancer effect of the taxol when used for preparing anticancer drugs. In the compound pharmaceutical composition provided by the invention, the taxol is the main anticancer component, and the traditional Chinese medicine extract monomeric compound improves the oral bioavailability and the anticancer effect of the taxol by inhibiting the first-pass effect of the taxol. Shown by experimental study, the compound pharmaceutical composition provided by the invention can be prepared into an oral medicament to improve the blood concentration and the anticancer effect of the taxol after oral administration.

Description

A compound pharmaceutical composition for improving paclitaxel oral bioavailability and application thereof technical field The invention relates to the field of pharmaceutical compositions, in particular to a compound pharmaceutical composition for improving the oral bioavailability of paclitaxel and its application. Background technique Paclitaxel, as a chemotherapy and anticancer drug with a special mechanism, is clinically used to treat a variety of malignant tumors, such as ovarian cancer, cervical cancer, breast cancer, laryngeal cancer, and esophageal cancer. Currently, paclitaxel preparations used clinically are injections. Due to the low solubility of paclitaxel in water, most of the injections currently used use polyoxyethylene castor oil / absolute ethanol (1:1, v / v) as excipients to increase the solubility of paclitaxel. , diluted with glucose or normal saline solution before use (Yang Tao, Wu Zongqun. Progress in Experimental and Clinical Application of Antitumo...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/704A61K31/443A61K31/366A61K31/36A61K31/357A61K31/353A61K31/352A61K31/337A61K31/216A61K31/122A61K31/12A61K31/09A61P35/00
Inventor 蔡大可黄民金晶毕惠嫦古练权
Owner SUN YAT SEN UNIV
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