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Citicoline sodium glucose injecta and preparation process thereof
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A technology of glucose injection and citicoline sodium is applied in the directions of medical preparations with non-active ingredients, medical preparations containing active ingredients, drug delivery, etc. The effect of quality stability, promotion of awakening, and good application prospects
Active Publication Date: 2013-04-10
HUNAN KELUN PHARMA
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[0037] (1) Add an appropriate amount of water for injection into the concentrated preparation tank, heat, put in the prescribed amount of glucose, malic acid, and sodium sulfite, stir to dissolve, add the prescribed amount of activated carbon for injection, boil for 15 minutes, and decarbonize the solution through a titanium rod filter , the filtrate is pumped into the dilute distribution tank.
[0038] (2) Put the prescribed amount of citicoline sodium and an appropriate amount of 10% sodium hydroxide solution into the dilute preparation tank, add water for injection to the full amount, and stir evenly.
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Abstract
The invention discloses a citicolinesodium glucose injecta and a preparation process thereof. The citicolinesodium glucose injecta mainly contains the active ingredients: citicolinesodium, isotonic agent glucose, a stabilizer, a pH regulator and water for injection, wherein the stabilizer is selected from one or two of malic acid, sale compounds thereof and sulfite compounds; the pH regulator is one or more of sodium hydroxide, hydrochloric acid, malic acid and apple sodium; the weight ratio of the active ingredients of the Citicoline sodium to the isotonic agent glucose is 1:(20-100), theweight ratio of the active ingredients of the citicoline sodium to the stabilizer is 1:(0.02-2), and the stabilizer is added to solve the problem of unstable heating and excessive related substances of the injecta in the production and storage process and improve the quality stability and the safe validation of medicaments.
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