Compound spray for treating cardiovascular and cerebrovascular diseases and preparation method of compound spraying
A cardiovascular and cerebrovascular disease and spray technology, which is applied in the field of medicine, can solve the problems of improper use, easy to cause danger, difficult to reverse the effect, troublesome absorption effect, etc., and achieve the effect of avoiding liver inactivation, fast onset and long shelf life.
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Embodiment 1
[0032] A compound spray for treating cardiovascular and cerebrovascular diseases, prepared according to the following preparation method:
[0033] a. respectively dissolving the crude drug consisting of the salvia miltiorrhiza extract and the total saponins of Panax notoginseng in ethanol; the extract of salvia miltiorrhiza in the bulk medicine accounts for 25%, and the total saponins of notoginseng accounts for 75%, calculated by weight percentage;
[0034] b. Add the solubilizing agent accounting for 1% to 10% of the total weight of the product solution into the mixed solution of the above-mentioned Danshen extract ethanol solution and Panax notoginseng saponins ethanol solution, mix well, pack in containers, press the cap, and The solubilizer is polysorbate, tween20, tween40, tween60 or tween80;
[0035] c. After capping, press the propellant filtered through the microporous membrane into the bottle under the pressure of 800kpa to get final product; the propellant is Freon,...
Embodiment 2
[0037] A compound spray for treating cardiovascular and cerebrovascular diseases, prepared according to the following preparation method:
[0038] a. Add 70%wt ethanol 13 times its weight to the Salvia miltiorrhiza extract, dissolve and stir to dissolve, and set aside; Add the alcohol solution of the salvia miltiorrhiza extract, stir to dissolve; wherein the salvia miltiorrhiza extract of the crude drug accounts for 42%, and the total saponins of notoginseng account for 58%, calculated by weight percentage;
[0039] b. The solubilizer Tween 20, which accounts for 3% of the total weight of the product solution, is added to the mixed solution of the above-mentioned Danshen extract ethanol solution and Panax notoginseng saponins ethanol solution. In the aerosol pressure-resistant container, with a gland;
[0040] c. After capping, press the propellant HFA-134a filtered through the microporous membrane into the bottle under a pressure of 900kpa to obtain final product; the consum...
Embodiment 3~9
[0042] Carry out by following material and processing condition, other are all identical with embodiment 2. The prepared spray of the present invention has good stability, no flocculation-like precipitation occurs for as long as 6-12 months, stable properties and remarkable curative effect.
[0043]
[0044]
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