Quartan Plasmodium inui animal model and establishing method of the same

A technology of animal models and establishment methods, applied in medical science, resistance to vector-borne diseases, surgery, etc., can solve problems such as immune difficulties and obstacles to the development of targeted antimalarial drugs, and achieve easy permanent preservation and molecular species of Plasmodium Attribute status clear effect

Inactive Publication Date: 2011-08-24
GUANGXI ZHUANG AUTONOMOUS REGION CENT FOR DISEASE CONTROL & PREVENTION
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Problems solved by technology

Therefore, this has brought difficulties to the in-depth study of different types of malaria and their immunity, and also hindered the development of targeted antimalarial drugs

Method used

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  • Quartan Plasmodium inui animal model and establishing method of the same
  • Quartan Plasmodium inui animal model and establishing method of the same
  • Quartan Plasmodium inui animal model and establishing method of the same

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Embodiment Construction

[0025] Purchased 5 wild monkeys captured in the local mountainous area in Guangxi, China, all male, including 2 rhesus monkeys (Macacamulatta) and 2 pig-tailed monkeys (Macaca nemestrina), 1 cynomolgus monkey (Macacafascicularis (Raffles, 1821)) 1 Only. During the 2-month animal quarantine observation period before the laboratory test, the body weight, tuberculosis, animal intestinal parasites, blood parasites and serological examinations were carried out. There are small trophozoites and large trophozoites, but the density of protozoa in blood is very low, with an average of 1 protozoa per 20 fields of view in thick blood film microscopy. The monkey serum was subjected to the Indirect Fluorescence Antibody Test (IFAT) for malaria, and the antibody titer was 1:1280 (the normal value should be less than 1:40). In order to confirm whether the protozoa belongs to Plasmodium simianus or other protozoa such as Cystoma simianus, the monkey blood is prepared to be intravenously infe...

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Abstract

The invention discloses a quartan Plasmodium inui animal model which is characterized by infecting a healthy monkey or an immune-deficient monkey through a Plasmodium inui CCTCC No. V201021. The Plasmodium inui belongs to quartan Plasmodium inui which is named as Plasmodium inui-China Huang. The invention also discloses an establishing method of the animal model. The model can be obtained by infecting various kinds of healthy monkeys through Anopheles dirus infection route or blood infection route and can be repeatedly passaged for using for a long time. The invention provides an ideal animal model for researches on physiology, pathology, immunology, pharmacology, molecular biology, etc. of plasmodium, lays a foundation for a deep research on quartan malaria, and provides a reliable basis for designing or screening targeted anti-malarial medicines.

Description

technical field [0001] The invention relates to a swine-tailed monkey Plasmodium China strain H (Plasmoiuminui-China Huang) found in wild monkeys in China, namely three-day-type simian Plasmodium, which can be transmitted to healthy monkeys through artificially reared Anopheles mosquitoes or direct blood infection , established a non-human primate Plasmodium animal model, especially a three-day-type monkey malaria animal model and its establishment method. Background technique [0002] Malaria is still one of the diseases causing the highest human morbidity and mortality in the world. According to the report of the World Health Organization, about 2.5-3.5 million people worldwide die of malaria infection every year. About 740,000 malaria patients are found in my country every year, and some patients with falciparum malaria are resistant to traditional antimalarial drugs. The incidence of malaria in the five northern provinces (Su, Shandong, Henan, Anhui, and Hubei) has rebou...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A61B19/00A61B90/00
CPCY02A50/30
Inventor 黄亚铭崔立旺傅伟忠韦海艳林康明毛玮区德锦邹春燕谢莉萍
Owner GUANGXI ZHUANG AUTONOMOUS REGION CENT FOR DISEASE CONTROL & PREVENTION
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