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Absorption-promoting pharmaceutical composition ointment for treating skin diseases and preparation method thereof

A skin disease and composition technology, applied in the field of medicine, can solve problems such as inability to more effectively treat skin fungal infection, and achieve a significant effect of curative effect

Inactive Publication Date: 2011-09-07
北京凯宾鸿生物医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It overcomes the shortcomings that a single component cannot effectively treat skin fungal infections, skin allergies, dermatitis, eczema, etc., or fungal infections and skin allergies, dermatitis, and eczema, etc. Serious side effects, and the preparation method of ointment of pharmaceutical composition for the treatment of skin disease

Method used

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  • Absorption-promoting pharmaceutical composition ointment for treating skin diseases and preparation method thereof
  • Absorption-promoting pharmaceutical composition ointment for treating skin diseases and preparation method thereof
  • Absorption-promoting pharmaceutical composition ointment for treating skin diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] formula:

[0017] Betamethasone valerate 61mg

[0018] Chlorcresol 100mg

[0019] Azithromycin Sulfate 100mg

[0020] Liquid paraffin 10g

[0021] Glyceryl monostearate 10g

[0022] White Vaseline 10g

[0023] Glycerin 10ml

[0024] Span 801.5g

[0025] Tween 803.5ml

[0026] Ethyl p-hydroxybenzoate 0.2g

[0027] Add double distilled water to 100g.

[0028] Preparation:

[0029] (1). Weigh liquid paraffin, glyceryl monostearate and white petrolatum according to the prescription, heat to about 80°C to form an oil phase, and set aside; in addition, dissolve glycerin, Span 80 and Tween 80 in a small amount of water, heat The water phase is formed at 80°C, and the ethyl p-hydroxybenzoate is directly added to the water phase to dissolve.

[0030] (2). Make the temperature of the water phase slightly higher than the temperature of the oil phase, gradually add the water phase to the oil phase, stir while adding until it condenses, and finally add water to the point ...

Embodiment 2

[0033] formula:

[0034] Betamethasone valerate 61mg

[0035] Chlorcresol 100mg

[0036] Azithromycin Sulfate 100mg

[0037] Liquid paraffin 10g

[0038] Glyceryl monostearate 10g

[0039] White Vaseline 10g

[0040] Glycerin 10ml

[0041] Span 801.5g

[0042] Tween 803.5ml

[0043] Azone 0.1g

[0044] Ethyl p-hydroxybenzoate 0.2g

[0045] Add double distilled water to 100g.

[0046] Preparation:

[0047] (1). Weigh liquid paraffin, glyceryl monostearate and white petrolatum according to the prescription, heat to about 80°C to form an oil phase, and set aside; in addition, dissolve glycerin, Span 80 and Tween 80 in a small amount of water, heat The water phase is formed at 80°C, and the ethyl p-hydroxybenzoate and azone are directly added into the water phase to dissolve.

[0048] (2). Make the temperature of the water phase slightly higher than the temperature of the oil phase, gradually add the water phase to the oil phase, stir while adding until it condenses, a...

Embodiment 3

[0051] formula:

[0052] Betamethasone valerate 61mg

[0053] Chlorcresol 100mg

[0054] Azithromycin Sulfate 100mg

[0055] Liquid paraffin 10g

[0056] Glyceryl monostearate 10g

[0057] White Vaseline 10g

[0058] Glycerin 10ml

[0059] Span 801.5g

[0060] Tween 803.5ml

[0061] Arginine octamer 0.08g

[0062] Ethyl p-hydroxybenzoate 0.2g

[0063] Add double distilled water to 100g.

[0064] Preparation:

[0065] (1). Weigh liquid paraffin, glyceryl monostearate and white petrolatum according to the prescription, heat to about 80°C to form an oil phase, and set aside; in addition, dissolve glycerin, Span 80 and Tween 80 in a small amount of water, heat The water phase is formed at 80°C, and ethyl p-hydroxybenzoate and arginine octamer are directly added into the water phase to dissolve.

[0066] (2). Make the temperature of the water phase slightly higher than the temperature of the oil phase, gradually add the water phase to the oil phase, stir while adding un...

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PUM

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Abstract

The invention discloses a preparation method of a pharmaceutical composition ointment for treating skin diseases. The pharmaceutical composition contains the following components in proportion by weight: 0.05-0.08% of betamethasone valerate, 0.08-0.12% of chlorocresol and 0.08-0.12% of gentamicin sulfate. The pharmaceutical composition ointment is mainly used for treating dermatitis, eczema, contact dermatitis, seborrheic dermatitis, photodermatitis, neurodermatitis, intertrigo, exfoliative dermatitis, skin itch, psoriasis, first-degree burn and the like. The pharmaceutical composition ointment has the characteristics of jointly applying pharmaceutical components with anti-inflammatory, antifungal and antibacterial curative effects, playing the curative effects in multiple aspects, overcoming the defect that an individual component can not more effectively treat skin mycotic infection, skin allergy, dermatitis, eczema and the like, or concurrence of mycotic infection, skin allergy, dermatitis, eczema and the like, and relieving the serious side effects caused by singly using a big amount of hormone for treating dermatitis, eczema and the like; and a component for promoting percutaneous absorption is added to auxiliary materials to enhance the pharmaceutical curative effect and promote absorption. The ointment disclosed by the invention has the advantages of exact efficacy, strong local pertinence, no irritation on skin, and the like, and the preparation method of the ointment is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition ointment for treating skin diseases, a preparation method thereof, and an application as a medicine for treating skin diseases. Background technique [0002] There are three main clinical skin diseases, namely: skin inflammation caused by foreign body stimulation, skin disease caused by fungal infection, and skin disease caused by bacterial infection. But skin disease is not caused independently, but inflammation, fungus and bacterial infection co-exist and cause. Because the inflammatory process of the skin creates conditions for the breeding and growth of pathogenic microorganisms, during the course of the disease, due to mutual infection, these conditions coexist. Therefore, single use of anti-inflammatory or anti-fungal, anti-bacterial infection drugs in clinic often cannot bring good curative effect. According to foreign reports, the clinical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K31/055A61K31/7036A61K31/235A61K31/155A61K31/192A61K9/06A61P17/00A61P17/04A61P17/06A61P17/02
Inventor 高钟镐金明姬董方言李伟
Owner 北京凯宾鸿生物医药科技有限公司
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