Pharmaceutical composition for treating depression

A composition and a technology for depression, applied in the field of medicine, can solve the problems of no disclosure of a dissolution detection method, and the dissolution results are in question.

Inactive Publication Date: 2011-10-19
北京美迪康信医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN101048791A discloses agomelatine pharmaceutical composition and its process. In this patent, agomelatine is passed through a 100-mesh sieve and mixed with pharmaceutical excipients to prepare oral preparations. Research, to determine the formulation prescription, but did not disclose the dissolution test method, the dissolution results are open to question

Method used

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  • Pharmaceutical composition for treating depression
  • Pharmaceutical composition for treating depression
  • Pharmaceutical composition for treating depression

Examples

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Comparison scheme
Effect test

Embodiment 1

[0068] A pharmaceutical composition for treating depression. The pharmaceutical composition is pulverized from raw material agomelatine to 20 μm (50% particle size less than or equal to 20 μm) by airflow, and mixed with pharmaceutical excipients to prepare tablets or capsules.

Embodiment 2

[0070] A pharmaceutical composition for the treatment of depression, the pharmaceutical composition is ground to 14μm (50% particle size less than or equal to 14μm) from raw material agomelatine with fluid energy, and mixed with pharmaceutical excipients to prepare tablets or capsules .

Embodiment 3

[0072] A pharmaceutical composition for treating depression. The pharmaceutical composition is made of raw material agomelatine colloidally ground to 8 μm (50% particle size is less than or equal to 8 μm), mixed with pharmaceutical auxiliary materials, and prepared into tablets or capsules.

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Abstract

The invention belongs to the technical field of medicines, and discloses a pharmaceutical composition for treating depression. The pharmaceutical composition is composed of a raw material agomelatine and auxiliary materials, wherein the raw material agomelatine is micronized agomelatine. Based on a deep research of the physical and chemical properties of agomelatine, the scientific researchers of the company accidentally find that agomelatine can be micronized for obtaining agomelatine with a certain particle size to produce a preparation, the invention has the advantages of uniform quality and good dissolution rate.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition for treating depression with a raw material of micronized agomelatine. [0002] The micronization in the present invention refers to a method including but not limited to mechanical grinding to reduce the particle size of the raw material to 75 μm or less. The raw material particle size in the present invention refers to at least 50% (more than or equal to 50% and less than 100%) of the particle size less than or equal to 75 μm. Background technique [0003] Depression is a common mental illness. The main clinical manifestations are low mood, decreased interest but not lost, pessimism, slow thinking, lack of initiative, self-crimination, poor diet and sleep, and fear of suffering from various diseases. This kind of disease makes the whole body feel uncomfortable. In severe cases, suicidal thoughts and behaviors may occur. Depression is the dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61K9/20A61K9/48A61P25/24
Inventor 吴劲松
Owner 北京美迪康信医药科技有限公司
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