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Gastrodin chronopharmaceutical medicine delivery preparation

A technology for gastrodin and preparations, which is applied in the field of gastrodin chronopharmaceutical preparations, can solve the problems of inability to achieve regular dosing and short biological half-life of gastrodin, and achieves the effects of high safety, short biological half-life and expanded application.

Active Publication Date: 2013-04-10
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a gastrodin hourly drug delivery preparation for the short biological half-life of gastrodin in the prior art and the inability to realize regular drug administration

Method used

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  • Gastrodin chronopharmaceutical medicine delivery preparation
  • Gastrodin chronopharmaceutical medicine delivery preparation
  • Gastrodin chronopharmaceutical medicine delivery preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: Prescription of gastrodin hour administration preparation

[0025]

[0026]

[0027] Preparation method: take gastrodin, lactose, microcrystalline cellulose and sodium starch glycolate powder (passed through 80 mesh sieve) and mix well, add 10% povidone ethanol solution to make soft material, granulate with 16 mesh sieve, and heat at 60°C Dry, granulate with a 14-mesh sieve, add magnesium stearate, mix evenly, press into tablets, and coat (coating the isolation layer first, then the controlled release layer) to obtain, each tablet contains 50 mg of gastrodin.

Embodiment 2

[0028] Embodiment 2: Prescription of gastrodin hour administration preparation

[0029]

[0030] Preparation method: take gastrodin, lactose granules, microcrystalline cellulose, hydroxypropyl cellulose, povidone, crospovidone, magnesium stearate and micropowder silica gel, mix well, directly compress, and coat (firstly) Pack the isolation layer, and then pack the controlled release layer), that is, each tablet contains 100 mg of gastrodin.

Embodiment 3

[0031] Embodiment 3: the prescription of gastrodin hour administration preparation

[0032]

[0033] Preparation method: take gastrodin, starch, microcrystalline cellulose, and low-substituted hydroxypropyl tensor cellulose fine powder (pass through 80 mesh sieve) and mix well, add 5% starch pulp to make soft material, granulate with 14 mesh sieve, and dry at 60 ℃ , 12 mesh sieve to granulate, add talcum powder, mix well, press tablet, coat (first cover the isolation layer, then cover the controlled release layer), that is, each tablet contains 75mg of gastrodin.

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Abstract

The invention discloses a gastrodin chronopharmaceutical medicine delivery preparation. The preparation consists of a coating and a tablet core containing gastrodin, an inner layer of the coating is an isolated layer, and an outer layer of the coating is a controlled release layer, wherein the isolated layer is made of hydroxypropyl methylcellulose, and the weight of the isolated layer accounts for 10 to 20 percent of the weight of the tablet core; and the controlled release layer is made of film coating agent and plasticizer, the weight ratio of the film coating agent to the plasticizer is 1:(0.1-0.3), and the weight of the controlled release layer accounts for 5 to 15 percent of the weight of the tablet core. The gastrodin is easily soluble in water, so the preset time lag is achieved by increasing the weight of the isolated layer and the controlled release layer of the coating, so that the aim that the gastrodin is released after being taken for 4 to 6h is fulfilled. The preparation is applicable to insomniacs who suffer from insufficient sleep caused by early morning awakening, is easy to prepare, and can be industrially produced conveniently.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a gastrodin hourly administration preparation. Background technique [0002] With the accelerated pace of life and increased mental pressure in today's society, insomnia has become one of the common pains, and it may be the most common clinical symptom besides pain. Long-term lack of sleep can cause patients to feel sleepy during the day, decrease concentration, affect physical and mental health and quality of life, and even suffer from depression in severe cases. The World Health Organization has conducted surveys in 14 countries, and about 27% of people have sleep problems. The incidence of insomnia is 20% in Japan, about 34% in the United States, and about 30% in my country, and it is increasing year by year. trend. About 20% of insomnia patients will seek drug treatment, so the market for hypnotics has also shown a steady growth trend accordingly. In 2008, the sal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K9/22A61K31/7034A61P25/20A61P25/04
Inventor 蔡铮刘中秋杨兆祥黄娟普俊学龚耘罗辉
Owner KPC PHARM INC
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