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Gastrodin chronopharmaceutical medicine delivery preparation

A gastrodin and preparation technology, applied in the field of gastrodin chronoadministration preparations, can solve the problems of inability to realize regular administration and short biological half-life of gastrodin, and achieve the effects of high safety, short biological half-life and expanded application

Active Publication Date: 2011-11-02
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a gastrodin hourly drug delivery preparation for the short biological half-life of gastrodin in the prior art and the inability to realize regular drug administration

Method used

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  • Gastrodin chronopharmaceutical medicine delivery preparation
  • Gastrodin chronopharmaceutical medicine delivery preparation
  • Gastrodin chronopharmaceutical medicine delivery preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Prescription of Gastrodin Chronoadministration Preparation

[0025]

[0026]

[0027] Preparation method: Mix gastrodin, lactose, microcrystalline cellulose, and sodium carboxymethyl starch powder (through a 80-mesh sieve), add 10% povidone ethanol solution to make a soft material, granulate with a 16-mesh sieve, and place at 60°C Dry, sieve with a 14-mesh sieve, add magnesium stearate, mix well, compress into tablets, and coat (firstly coat with an isolation layer, then coat with a controlled-release layer), and each tablet contains 50 mg of gastrodin.

Embodiment 2

[0028] Example 2: Prescription of Gastrodin Chronoadministration Preparation

[0029]

[0030] Preparation method: take gastrodin, lactose granules, microcrystalline cellulose, hydroxypropyl cellulose, povidone, crospovidone, magnesium stearate and micropowder silica gel, mix well, directly compress tablets, and coat (previously Wrap an isolation layer, and then wrap a controlled-release layer), to obtain that each tablet contains 100 mg of gastrodin.

Embodiment 3

[0031] Example 3: Prescription of Gastrodin Chronoadministration Preparation

[0032]

[0033] Preparation method: Take gastrodin, starch, microcrystalline cellulose, and low-substituted hydroxypropyl Zhangweisu fine powder (through 80 mesh sieve) and mix evenly, add 5% starch slurry to make soft material, granulate with 14 mesh sieve, and dry at 60°C , 12-mesh sieve, add talcum powder, mix well, compress into tablets, and coat (coat with isolation layer first, then with controlled-release layer), to get that, each tablet contains 75mg of gastrodin.

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Abstract

The invention discloses a gastrodin chronopharmaceutical medicine delivery preparation. The preparation consists of a coating and a tablet core containing gastrodin, an inner layer of the coating is an isolated layer, and an outer layer of the coating is a controlled release layer, wherein the isolated layer is made of hydroxypropyl methylcellulose, and the weight of the isolated layer accounts for 10 to 20 percent of the weight of the tablet core; and the controlled release layer is made of film coating agent and plasticizer, the weight ratio of the film coating agent to the plasticizer is 1:(0.1-0.3), and the weight of the controlled release layer accounts for 5 to 15 percent of the weight of the tablet core. The gastrodin is easily soluble in water, so the preset time lag is achieved by increasing the weight of the isolated layer and the controlled release layer of the coating, so that the aim that the gastrodin is released after being taken for 4 to 6h is fulfilled. The preparation is applicable to insomniacs who suffer from insufficient sleep caused by early morning awakening, is easy to prepare, and can be industrially produced conveniently.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a gastrodin time-administered preparation. Background technique [0002] With the accelerated pace of life and increased mental stress in today's society, insomnia has become one of the ubiquitous pains, and it may be the most common clinical symptom except pain. Long-term lack of sleep can cause patients to feel sleepy during the day, decrease their concentration, affect their physical and mental health and quality of life, and even cause depression in severe cases. The World Health Organization has conducted surveys in 14 countries. About 27% of people have sleep problems. The incidence rate of insomnia in Japan is 20%, the United States is about 34%, and the incidence rate in my country is as high as about 30%, and it is increasing year by year. trend. About 20% of insomnia patients will seek drug treatment, so the hypnotic drug market is also showing a steady growt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K9/22A61K31/7034A61P25/20A61P25/04
Inventor 蔡铮刘中秋杨兆祥黄娟普俊学龚耘罗辉
Owner KPC PHARM INC
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