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Method for extracting ursolic acid with Folium Forsythia as raw material

A technology of ursolic acid and forsythia leaves, applied in the direction of steroids, organic chemistry, etc., can solve problems such as unsuitability for large-scale industrial production, hazards to production equipment and production personnel, waste of forsythia leaves, etc., to achieve reduction in dosage and Effects of energy consumption, production cost reduction, and reduction in the number of treatments

Inactive Publication Date: 2012-08-15
河南省科高植物天然产物开发工程技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent 03108037.5 uses Paulownia leaves as raw materials and uses methanol to extract ursolic acid. The preparation process involves methanol, a toxic chemical reagent, which is potentially dangerous in large-scale production and has certain risks for production equipment and production personnel. Hazardous, not suitable for large-scale industrial production
Forsythia fruit is used as medicine in traditional Chinese medicine, and a large number of forsythia leaves are discarded, resulting in a serious waste of resources
At present, there is no relevant report on extracting ursolic acid from forsythia leaves

Method used

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  • Method for extracting ursolic acid with Folium Forsythia as raw material
  • Method for extracting ursolic acid with Folium Forsythia as raw material
  • Method for extracting ursolic acid with Folium Forsythia as raw material

Examples

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Embodiment 1

[0038] A method for extracting ursolic acid using forsythia leaves as a raw material, comprising the steps of:

[0039]①Coarse extraction: Mix 5kg of forsythia leaves and 50kg of water and cook at 80°C for 1.5 hours (extraction 2 times). time, each extraction for 1 hour, the amount of ethanol added in the first extraction was 5 times of the weight of the residue, and the amount of ethanol added in the second extraction was 3 times of the weight of the residue), the alcohol extracts combined twice were filtered out The residue and the filtrate were left to cool to room temperature naturally, and the precipitate (ie crude ursolic acid) and the supernatant were obtained from the filtrate, and the precipitate and the supernatant were separated. After precipitation and drying, 164 g of crude ursolic acid was obtained with a purity of 41.5%. The supernatant can be reused as an extraction solvent for new raw materials.

[0040] 2. Refining: Decolorize the gained ursolic acid crude ...

Embodiment 2

[0042] A method for extracting ursolic acid using forsythia leaves as a raw material, comprising the steps of:

[0043] ①Coarse extraction: mix 3.5kg of forsythia leaves and 28kg of water and cook at 90°C for 1 hour (extraction twice). 2 times, each extraction for 1 hour, the amount of ethanol added during the first extraction was 8 times the weight of the residue, and the amount of ethanol added during the second extraction was 4 times the weight of the residue), the alcohol extracts were combined twice, filtered Remove the residue, let the filtrate stand and cool down to room temperature naturally, and obtain the precipitate (ie crude ursolic acid) and supernatant separated from the filtrate, and separate the precipitate and supernatant. After precipitation and drying, 112 g of crude ursolic acid was obtained with a purity of 40.8%. The supernatant can be reused as an extraction solvent for new raw materials.

[0044] ② Refining: The obtained crude ursolic acid was decolor...

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Abstract

The invention relates to a method for extracting ursolic acid with Folium Forsythia as a raw material, comprising the following steps of: (1) crude extraction: poaching Folium Forsythia, carrying out reflux extraction for 1-4 times on the poached residue with the addition of ethanol, merging the above alcohol extracts, carrying out solid-liquid separation to remove residues, naturally cooling thefiltrate to room temperature, precipitating an ursolic acid crude product from the filtrate; (2) refining: carrying out decolouring, crystallization and recrystallization treatments on the ursolic acid crude product to obtain white acicular ursolic acid crystals with the purity being more than 95%. With abundant Folium Forsythia as the raw material, the method provided by the invention can be used for accomplishing batch production of ursolic acid, greatly raising the solvent extraction efficiency and dramatically reducing the solvent amount and energy consumption, has advantages of simple extraction technology, low production cost, high product yield and high purity, and is suitable for large-scale continuous production.

Description

technical field [0001] The invention relates to a method for extracting ursolic acid from plants, in particular to a method for extracting ursolic acid from forsythia leaves. Background technique [0002] Ursolic acid, also known as ursolic acid, molecular formula C 30 h 18 o 3 , with a molecular weight of 456.68, is a pentacyclic triterpenoid compound that exists in many natural plants. It has various biological effects such as anti-hepatitis, anti-tumor, anti-AIDS virus, antibacterial, anti-inflammatory, sedative, anti-diabetic, and anti-ulcer. It has important uses in medicine and health care, daily chemical industry, functional food, etc., and has become a hot spot of research and development at home and abroad. [0003] Due to the complex structure of ursolic acid and the difficulty of artificial synthesis, it is extracted and separated from natural plants at home and abroad. Domestic raw materials for extracting ursolic acid mainly include privet leaves, hawthorn l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00
Inventor 李晓董建军范毅郭唯赵天增魏悦李倩于立芹陈玲
Owner 河南省科高植物天然产物开发工程技术有限公司
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