Photoaging inhibitor and skin thinning inhibitor

An inhibitor and photoaging technology, used in skin diseases, skin care preparations, cosmetics, etc., can solve problems such as unseen PQQ

Inactive Publication Date: 2011-11-09
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Regarding the thinning of the skin, there is no research literature on how PQQ is related

Method used

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  • Photoaging inhibitor and skin thinning inhibitor
  • Photoaging inhibitor and skin thinning inhibitor
  • Photoaging inhibitor and skin thinning inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1~3 and comparative example 1

[0124] According to the composition described in Table 1 below, after dissolving PQQ in purified water at room temperature, ethoxydiglycol was added to the obtained solution, and mixed for 5 minutes to obtain each photoaging inhibitor. Comparative Example 1 is a control that does not contain a photoaging inhibiting component. In addition, the numerical value in Table 1 shows weight%.

[0125] [Table 1]

[0126]

Embodiment 4~7 and comparative example 2

[0138] According to the composition described in Table 2 below, after dissolving PQQ in purified water at room temperature, ethoxydiglycol was added to the resulting solution and mixed for 5 minutes to obtain each photoaging inhibitor. Comparative Example 2 is a control that does not contain a photoaging inhibiting component. In addition, the numerical value in Table 2 shows weight%.

[0139] [Table 2]

[0140]

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PUM

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Abstract

The invention provides a new agent which is effective in inhibiting photoaging, especially inhibiting wrinkles generated by ultraviolet rays or skin thinning. The application of pyrro-quinoline quinine and / or salt allowed by the pharmacology of the pyrro-quinoline quinine in the preparation of the photoaging inhibitor is provided.

Description

technical field [0001] The present invention relates to photoaging inhibitors and skin thinning inhibitors. More specifically, the present invention particularly relates to photoaging inhibitors and skin thinning inhibitors useful as inhibitors of ultraviolet-induced wrinkling. Background technique [0002] Pyrroloquinoline quinone (hereinafter sometimes abbreviated as "PQQ") is a substance isolated and identified from metabolites of methanol-utilizing bacteria, and is confirmed to exist in eukaryotic fungi, enzymes, and mammals. [0003] A lot of research has been done on the biological activity of PQQ, and so far, it has been confirmed that PQQ or its derivatives have antioxidant effects, mitochondrial activation effects, ultraviolet absorption effects, skin aging prevention effects, active oxygen removal effects, and photoaging prevention effects. Effect (this effect has been confirmed for derivatives of PQQ), anti-allergic effect, reverse transcriptase inhibitory effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4745A61P17/16A61K8/49A61Q19/00
Inventor 秋吉美那桑原亚希子黄济华须田一真
Owner ROHTO PHARM CO LTD
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