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Sodium phosphate composition

A technology of sodium phosphate salt and composition, applied in the field of sodium phosphate salt composition, can solve problems such as inconvenience to carry, hidden safety hazards, inconvenience to use and the like

Active Publication Date: 2012-12-19
四川健能制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oral solution is inconvenient to carry, and contains preservatives, which has potential safety hazards and is not suitable for elderly patients or children
When the tablets are administered orally, the dosage for cleaning the intestinal tract is 40 tablets, and 20 tablets are taken the night before surgery or colonoscopy, 3 tablets each time, each time with about 220-250ml of drinking water. The last time is 2 tablets, take it every 15 minutes; then take 20 tablets in the same way 3 to 5 hours before the operation or colonoscopy, the number of tablets taken is too large, which will bring inconvenience to the patient

Method used

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  • Sodium phosphate composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Sodium Phosphate Powder

[0021] 1. Prescription:

[0022] Sodium dihydrogen phosphate (in the form of monohydrate 21.6kg) 18.8kg

[0023] Disodium hydrogen phosphate (in anhydrous form) 4.3kg

[0024] Simethicone 0.15kg

[0025] Silica 0.1kg

[0026] A total of 1000 bags were made

[0027] 2. Process steps:

[0028] (1) Initial mixing: take the prescribed amount of sodium dihydrogen phosphate, disodium hydrogen phosphate, simethicone, and silicon dioxide, and place them in a mixer for initial mixing for 3 minutes;

[0029] (2) Powder sifting: grind powder in a universal pulverizer, pass through an 80-mesh sieve, and obtain mixed powder;

[0030] (3) Total mixing: the mixed powder is mixed in a mixer for 3 minutes, fully mixed evenly, and sealed for storage;

[0031] (4) Bagging.

[0032] 3. Usage and dosage

[0033] Oral administration: 52.3g (2 bags) for cleaning the intestinal tract once. Take 26g the night before surgery...

Embodiment 2

[0035] Sodium Phosphate Powder

[0036] 1. Prescription:

[0037] Sodium dihydrogen phosphate (in the form of monohydrate 21.6kg) 18.8kg

[0038] Disodium hydrogen phosphate (in anhydrous form) 4.3kg

[0039] Simethicone 0.15kg

[0040] Glucose 2.35kg

[0041] Silica 0.1kg

[0042] A total of 1000 bags were made

[0043] 2. Process steps:

[0044] (1) Preliminary mixing: Weigh the prescribed amount of sodium dihydrogen phosphate, disodium hydrogen phosphate, simethicone, silicon dioxide, and glucose, and place them in a mixer for initial mixing for 3 minutes;

[0045] (2) Powder sifting: grind powder in a universal pulverizer, pass through an 80-mesh sieve, and obtain mixed powder;

[0046] (3) Total mixing: the mixed powder is mixed in a mixer for 3 minutes, fully mixed evenly, and sealed for storage;

[0047] (4) Bagging.

[0048] 3. Usage and dosage

[0049] Oral administration: 57g (2 bags) for cleaning the intestinal tract once...

Embodiment 3

[0051] Sodium Phosphate Powder

[0052] 1. Prescription:

[0053] Disodium hydrogen phosphate (in anhydrous form) 4.3kg

[0054] Sodium dihydrogen phosphate (in the form of monohydrate 21.6kg) 18.8kg

[0055] Aspartame 0.2kg

[0056] Glycerin 0.05kg

[0057] Lemon essence 0.04kg

[0058] Simethicone 0.15kg

[0059] Silica 0.5kg

[0060] A total of 1000 bags were made

[0061] 2. Process steps:

[0062] (1) Initial mixing: Weigh the prescribed amount of sodium dihydrogen phosphate, disodium hydrogen phosphate, simethicone, and glycerin, and place them in a mixer for initial mixing for 3 minutes;

[0063] (2) Powder sifting: grind powder in a universal pulverizer, pass through an 80-mesh sieve, and obtain mixed powder;

[0064] (3) Total mixing: add the prescribed amount of aspartame, lemon essence, and silicon dioxide to the mixed powder, mix in the mixer for 3 minutes, fully mix evenly, and seal and store;

[0065] (4) Bagging.

[0...

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PUM

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Abstract

The invention discloses a sodium phosphate composition comprising sodium dihydrogen phosphate, disodium hydrogen phosphate and dimeticone. The composition has notable clinical effect on cleaning the intestinal tract, good cleanliness of the intestinal tract, good tolerance of patients and small water-electrolyte imbalance.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a sodium phosphate salt composition for cleaning the intestinal tract. Background technique [0002] Bowel cleansing is an important preparation before surgery or colon X-ray and bowel endoscopy. The pros and cons of intestinal preparation directly affect the exposure of the field of view during surgery and X-ray or intestinal endoscopy. Insufficient preparation can directly increase the difficulty of surgery and X-ray or intestinal endoscopy. Traditional intestinal cleaning methods There are the following types: [0003] 1. Enema method: soapy water, normal saline or clear water are commonly used as solutions. This method not only easily damages the lower rectal mucosa and causes poor effect of liquid resorption, but also has cumbersome operation and heavy workload. Patients often go to the toilet and defecation is not easy to control , patients are not eas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/80A61K31/7004A61K33/42A61P1/10
Inventor 王国华李侠
Owner 四川健能制药有限公司
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