Surface-enhanced Raman scattering active substrate based on star-shaped gold nanoparticles and preparation method thereof

A surface-enhanced Raman and active substrate technology, applied in Raman scattering, nanotechnology, material excitation analysis, etc., can solve the problems of low cost, consistency and repeatability at the same time, and achieve good enhancement effect and convenient preparation , the effect of simple preparation method

Inactive Publication Date: 2011-11-23
SOUTHEAST UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

Unfortunately, the currently reported substrates have certain shortcomings, and cannot meet the requirements of low cost, consistency, repeatability, stability, and enhancement effects at the same time. Especially in terms of large-scale preparation, the preparation of substrates is required The method needs to meet the three aspects of good repeatability, simple preparation method and enhanced effect at the same time

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  • Surface-enhanced Raman scattering active substrate based on star-shaped gold nanoparticles and preparation method thereof
  • Surface-enhanced Raman scattering active substrate based on star-shaped gold nanoparticles and preparation method thereof
  • Surface-enhanced Raman scattering active substrate based on star-shaped gold nanoparticles and preparation method thereof

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Effect test

Embodiment 1

[0032] A surface-enhanced Raman scattering active substrate based on gold nanostars, comprising: a glass substrate 1 covered with a positively charged amino layer 2 on which stars are adsorbed gold nanoparticle layer 3 . The preparation method steps of this substrate are:

[0033] 1. Add 1 M sodium hydroxide aqueous solution to 100 mL of 0.04 M N-(2-hydroxyethyl) piperazine-N'-2 sulfonic acid aqueous solution to adjust the pH of the system to 7.4, then add 700 μL The aqueous solution of chloroauric acid with a concentration of 1% in mass volume ratio is mixed and placed in a water bath at 28°C for 1 hour to stand for reaction. During this process, the color of the solution changes as follows: light yellow-colorless-light pink-purple-blue- - Blue-green, the color of the solution is stable and no longer changes, indicating that the reaction is terminated, and the star-shaped gold nanoparticle solution required for assembling the substrate is generated. The solution is character...

Embodiment 2

[0038] A gold nanostar-based SERS active substrate with good enhancement effect, low cost, simple and repeatable preparation method and a preparation method thereof, the steps are as follows:

[0039] 5. Add 1 M sodium hydroxide aqueous solution to 100 mL of 0.04 M N-(2-hydroxyethyl) piperazine-N'-2 sulfonic acid aqueous solution to adjust the pH of the system to 7.4, then add 700 μL The aqueous solution of chloroauric acid with a concentration of 1% in mass volume ratio is mixed and placed in a water bath at 28°C for 1 hour to stand for reaction. During this process, the color of the solution changes as follows: light yellow-colorless-light pink-purple-blue- - Blue-green, the color of the solution is stable and no longer changes, indicating that the reaction is terminated, and the star-shaped gold nanoparticle solution required for assembling the substrate is generated. The solution is characterized under the ultraviolet-visible-near-infrared spectrophotometer. The particle s...

Embodiment 3

[0046] 1. Preparation of Gold Nanostars

[0047] Add 1M aqueous sodium hydroxide solution to 100 mL of 0.04M N-(2-hydroxyethyl)piperazine-N'-2sulfonic acid aqueous solution to adjust the pH of the system to 7.4, and then add 700 μL mass volume Chlorauric acid aqueous solution with a specific concentration of 1%, after mixing, place it in a water bath at 28°C for 1 hour, and the color of the solution changes during this process: light yellow-colorless-light pink-purple-blue-blue Green, the color of the solution is stable and no longer changes, indicating that the reaction is terminated, and the star-shaped gold nanoparticle solution required for assembling the substrate is generated, and the solution is characterized by a UV-visible-near-infrared spectrophotometer. There should be two extinction peaks, one of which is at 532 ± 10nm, and the other should be at 700 ± 5nm. For example, the positions of the two extinction peaks of the gold nanostar solution prepared in this example...

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Abstract

The invention relates to a surface-enhanced Raman scattering (SERS) active substrate based on star-shaped gold nanoparticles and a preparation method thereof, wherein the SERS active substrate is good in enhancement effect, low in cost, simple and convenient in preparation method and good in repeatability. By dipping an ammonified glass sheet into a star-shaped gold nanoparticle solution, the highly uniform SERS active substrate is obtained through the function of static adsorption under the effect of magnetically agitating at a low speed. According to the invention, the star-shaped gold nanoparticles are combined with a static self-assembly method, excellent SERS effect of the star-shaped gold nanoparticles is used for making up main deficiency in preparation of the SERS substrate by using the static self-assembly method, therefore, the high-efficiency SERS active substrate which is simple in preparation method and good in both repeatability and enhancement effect is formed.

Description

technical field [0001] The invention belongs to the technical field of nano-biological analysis, and in particular relates to a surface-enhanced Raman scattering active substrate based on gold nanostars with good enhancement effect, low cost, simple preparation method and good repeatability and a preparation method thereof. Background technique [0002] Surface-enhanced Raman Scattering (SERS), as a spectroscopic analysis technique with development potential, has been applied in various fields such as chemistry, physics, biology, medicine, environmental monitoring, and public safety. SERS is mainly an abnormal optical enhancement phenomenon of nanoscale rough surfaces or particle systems, which can amplify the Raman signals of molecules adsorbed on the surface of materials by about 10 6 times, for the surface of the substrate with special nanoscale particle morphology distribution, the signal enhancement can even be as high as 10 14 times. The preparation of active substra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65B82Y40/00
Inventor 钱卫平苏倩倩孙茜马小媛董健
Owner SOUTHEAST UNIV
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