A kind of repaglinide chitosan sustained and controlled release microspheres and preparation method thereof

A chitosan and microsphere technology, applied in the field of medicine and chemical industry, can solve the problems of inability to effectively control hyperglycemia, short gastrointestinal tract existence time, short half-life of repaglinide, etc., and achieve uniform quality, easy operation and control conditions. less demanding effects

Inactive Publication Date: 2011-12-07
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Repaglinide, the chemical name is S(+)-2-ethoxy-4-{2-[(3-methyl-1-(2-(1-piperidinyl)phenyl)butyl) Base) amino] -2-oxoethyl} benzoic acid, which belongs to insulin secretagogues, is clinically used for the treatment of type Ⅱ diabetes mellitu

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of repaglinide chitosan sustained and controlled release microspheres and preparation method thereof
  • A kind of repaglinide chitosan sustained and controlled release microspheres and preparation method thereof
  • A kind of repaglinide chitosan sustained and controlled release microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0043]

[0044] Embodiments 1-5 are respectively a kind of repaglinide chitosan sustained and controlled release microsphere preparation and preparation method thereof, and the raw material formula of making corresponding preparation is referred to above table, and their preparation method carries out according to the following sequence of steps respectively:

[0045] (1) Preparation of chitosan solution A

[0046] Dissolving chitosan in 2% acetic acid solution, ultrasonically eliminating air bubbles, and preparing chitosan solution A with a weight-to-volume ratio of chitosan and acetic acid solution of 1-6 grams: 100 ml;

[0047] (2) Preparation of Solution D

[0048] dissolving repaglinide in a solvent to prepare solution B of repaglinide;

[0049] Add solution B to chitosan solution A, then add PEG and magnesium stearate, and stir well to obtain mixture C;

[0050] Add the mixture C to the dispersion medium containing the emulsifier, and stir evenly to obtain the solut...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a preparation of repaglinide chitosan sustained and controlled release microspheres and a preparation method thereof. The core-shell microsphere preparation is formed in the capsule material formed by condensation and cross-linking of polysaccharides. The preparation has slow and controlled release of drugs, and significantly improves the stability of repaglinide. The capsule material prepared by natural cross-linking agent and chitosan has good biocompatibility without any cytotoxicity, and can promote the absorption of drugs , improve the bioavailability of the drug. The invention is used for preparing repaglinide chitosan sustained and controlled release microspheres, and the medicine in dosage form is mainly used for preventing and treating type Ⅱ diabetes mellitus with high blood sugar.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and relates to a slow and controlled release microsphere and a preparation method thereof, in particular to a repaglinide chitosan slow and controlled release microsphere and a preparation method thereof. Background technique [0002] Repaglinide, the chemical name is S(+)-2-ethoxy-4-{2-[(3-methyl-1-(2-(1-piperidinyl)phenyl)butyl) Base) amino] -2-oxoethyl} benzoic acid, which belongs to insulin secretagogue, is clinically used for the treatment of type Ⅱ diabetes mellitus whose hyperglycemia cannot be effectively controlled by diet control and exercise. However, because the half-life of repaglinide is very short, usually only 1-2 hours, the existence time in the gastrointestinal tract is short, and the bioavailability is very low. [0003] Chitosan (CS) is a good bioorganic carrier currently used in drug sustained and controlled release preparations. It can solubilize drugs, promote...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/16A61K31/451A61K47/36A61P3/10
Inventor 张越于奕峰尚振华
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap