A drug-coated titanium nail with chitosan gelatin as carrier

Abstract

The invention belongs to the field of medical devices, and specifically relates to a drug-coated titanium nail with chitosan gelatin as a carrier, which is characterized in that: the thickness of the coating on the titanium nail is 0.001-10 mm; Titanium nails are used for open and endoscopic anastomotic staplers, skin sutures, linear staplers, and clip applicators. The diameter of the titanium nails is 0.1-5.0. The titanium nails are made of TA1, TA2 and the metal nails are made of 316LVM stainless steel, self-reinforced poly-L A coating of lactide SR-PLLA12 nails and self-reinforced poly-L-polyglycolide SR-PGA nails, the chitosan gelatin titanium nails can perform chitosan for human implants, artificial organs, catheters Sugar gelatin coating treatment or coating treatment using chitosan gelatin as drug controlled release carrier, the method is simple and easy, the prepared chitosan gelatin coated titanium nail meets the clinical application requirements, chitosan gelatin coated titanium nail can It promotes tissue healing, has good stability, is not easy to wash off, is safe to use, is suitable for large-scale industrial production, and is simple to operate and low in cost.

Description

Technical field: [0001] The invention belongs to the field of medical devices, in particular to a drug-coated titanium nail with chitosan gelatin as a carrier. Background technique: [0002] Titanium nails are widely used in the field of medical devices, and are often used in surgical stomach, lung and other tissues and gastrointestinal surgical tissues. However, due to the biological inertia of titanium, when the suture area oozes, inflammation, etc., it will lead to suture failure. Titanium nails When healing with the surrounding tissue, the surface properties of titanium nails play a key role in the organization. Therefore, many technical methods for surface modification of titanium nails have been proposed in the field of medical devices, including improving the physical and chemical properties, surface morphology, and biochemical properties of titanium nails. Wait, [0003] Chitosan gelatin is the only positively charged alkaline polysaccharide found in nature. It is w...

AI Technical Summary

Problems solved by technology

[0003] Chitosan gelatin is the only positively charged alkaline polysaccharide found in nature. It is widely used in the biomedical field because of its good biocompatibility, degradability, and antibacterial properties. It is constructed on the surface of titanium nails. Chitosan gelatin coating can improve the biological activity of titanium surface. In addition, this coating can further add functional molecules to make the surface of titanium nails obtain corresponding biological functions. Although there are many methods of coating at present, the traditional method There are solution distillation method, coupling agent method, electrostatic layer-by-layer self-assembly method, etc. The solution distillation method is to put titanium nails into the blend solution of chitosan gelatin and biological protein, and the solution will form a shell on the surfac