Benzimidazole drug oil suspension

A technology of benzimidazole and medicinal oil, applied in the field of antiparasitic drugs, can solve problems such as no good clinical effect, widespread spread of echinococcosis, unsuitable surgery for cases, etc., to improve bioavailability and reduce dosage and course of treatment, the effect of reducing the cost of treatment

Active Publication Date: 2011-12-14
STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Before the 1970s, the main treatment for echinococcosis was surgical resection, but there were problems such as recurrence after surgery, leakage of a large number of protoscolees during surgery, causing widespread dissemination of echinococcosis, and some cases

Method used

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  • Benzimidazole drug oil suspension
  • Benzimidazole drug oil suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of mebendazole oleic acid suspension

[0024] Weigh 0.5g of mebendazole, add 0.5ml of Span80, 10ml of peanut oil, 10ml of soybean oil, add oleic acid to 100ml, stir in a ball mill for one hour to prepare a suspension of mebendazole oleic acid, the concentration of mebendazole It is 5mg / ml.

Embodiment 2

[0025] Example 2 Preparation of mebendazole soybean oil suspension

[0026] Weigh 0.5g of mebendazole, add Tween800.5ml, olive oil 10ml, oleic acid 10ml, add soybean oil to 100ml, stir in a ball mill for one hour to prepare mebendazole soybean oil suspension. The concentration is 5mg / ml.

Embodiment 3

[0027] Example 3 Preparation of albendazole oleic acid suspension

[0028] Weigh 0.5g of albendazole, add Span800.5ml, peanut oil 10ml, soybean oil 10ml, add oleic acid to 100ml, stir in a ball mill for one hour to prepare albendazole oleic acid suspension, albendazole The concentration is 5mg / ml.

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PUM

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Abstract

The invention provides a new formulation, namely oil suspension agent, of antiparasitic benzimidazole medicine. The oil suspension agent comprises benzimidazole medicine, a liquid grease, a suspending agent and a wetting agent. The oil suspension agent of benzimidazole medicine provided by the invention is used for treating echinococcosis and other parasitic diseases and can be used for increasing blood concentration and improving curative effects. The oil suspension agent has simple preparation method, good stability and easiness in popularization.

Description

Invention field [0001] The invention relates to antiparasitic drugs, in particular to the reformation of the dosage form of benzimidazole drugs, and more specifically to the oil suspension of benzimidazole drugs. Background technique [0002] Hydatid disease is a global human and zoonotic disease that causes serious damage to the health of humans and livestock. Hydatid disease is a disease caused by the larvae of Echinococcus parasitic in the body of an intermediate host. The main echinococcosis in my country are cystic echinococcosis (echinococcus granulosus) and alveolar echinococcosis (echinococcus granulosus). They are composed of larvae of Echinococcus granulosus (echinococcus granulosus). ) And larvae of Echinococcus multilocularis (Echinococcus multilocularis) parasitize human and animal tissues and organs. The development of echinococcosis in the body is slow, mainly due to chronic consumption, which often makes the patient lose the ability to work, especially the alveol...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/4184A61K47/44A61P33/14
Inventor 张皓冰伍卫平刘丛珊薛剑陶奕姜斌徐莉莉姚俊敏肖树华王立英温爱丹张超威
Owner STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
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