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Methods and compositions for treating bone loss

A technique for bone loss, hand bone, applied in the field of predicting bone loss including but not limited to hand bone loss, indicators of bone loss such as hand bone loss, treating hand bone loss in subjects

Inactive Publication Date: 2011-12-14
ABBVIE BIOTECHNOLOGY LTD
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  • Abstract
  • Description
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Problems solved by technology

[12] However, in addition to its anti-inflammatory effects, prednisolone is also known to cause osteoporosis

Method used

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  • Methods and compositions for treating bone loss
  • Methods and compositions for treating bone loss
  • Methods and compositions for treating bone loss

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0168] Example: Anti-TNFα Treatment Reduces Bone Loss

[0169] A. Adalimumab therapy reduces hand bone loss in patients with early rheumatoid arthritis

[0170] general overview

[0171] One objective of this study (Study J) was to compare cortical hand bone loss in patients with early rheumatoid arthritis (RA) across 3 treatment arms: adalimumab plus methotrexate (MTX ); adalimumab monotherapy; and MTX monotherapy. A secondary objective was to search for predictors of hand bone loss.

[0172] In general, the study included 768 patients with active RA <3 years who were naive to MTX. Clinical data collection and radiographic examinations of the hands were performed at baseline, and after 26, 52, and 104 weeks of treatment. Hand bone loss was assessed by digital x-ray radiography (DXR), primarily as the Metacarpal Cortical Index (MCI), on the same radiographs used for joint injury assessment.

[0173] The results showed a median percent loss of DXR-MCI at 52 weeks (-2.87 vs...

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Abstract

The invention provides methods and compositions for treating, eg, reducing bone loss, such as cortical bone loss, and particularly hand bone loss, comprising administering a TNFα inhibitor, such as a human TNFα antibody or an antigen-binding portion thereof.

Description

[0001] related application [0002] This application claims the benefit of priority to US Provisional Application No. 61 / 039028, filed March 24, 2008, and US Provisional Application No. 61 / 148313, filed January 29, 2009. The contents of all of the above-mentioned priority applications are hereby incorporated by reference in their entirety. Background of the invention [0003] Bone loss is characterized by the structural deterioration of bone tissue, which can lead to bone fragility and increased susceptibility to fractures. Bone loss is associated with many diseases, including osteoporosis, osteoarthritis and rheumatoid arthritis. [0004] In rheumatoid arthritis (RA), for example bone lesions on radiographs appear not only as erosions but also as periarticular osteoporosis. [1] Data exist on the importance of suppressing inflammation to avoid bone damage in RA. Effective anti-inflammatory treatments have been shown to reduce the progression of joint erosions through the re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/24A61K39/395
CPCC07K2317/21A61K2039/505A61K39/3955C07K16/241A61K31/519A61P19/02A61P19/08A61P19/10A61P29/00A61P43/00A61K2300/00
Inventor A·埃尔登G·海于格伯格
Owner ABBVIE BIOTECHNOLOGY LTD
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