Cockroach extractive and prepared oral care composition as well as preparation method and applications

A technology of oral care and extract, which is applied in the field of cockroach extraction and pharmaceuticals, to achieve the effect of preventing bleeding gums and repairing oral ulcers

Active Publication Date: 2012-11-28
YUNNAN TENGCHONG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern scientific research shows that cockroach extracts have strong biological activity, but the application of cockroach extracts in the prior art still has great limitations, and the biologically active substances extracted from cockroaches have not been developed to have anti-inflammatory properties. , repair oral ulcers, and prevent gum bleeding, so the application potential of cockroach extract needs to be further developed and utilized

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Crush 1000g of dried cockroaches into coarse powder, extract with 5 times the weight ratio of 70% ethanol under heat reflux for 8 hours, and concentrate the filtrate under reduced pressure at 60°C to a relative density of 1.0-1.2 to obtain a crude paste, pour the crude paste into oil and water Separator, add 6 times the weight of purified water and stir well, let it stand for 12 hours, remove the bottom layer of sediment and upper layer of grease, collect the brown liquid in the middle layer, then add activated carbon, stir well and stand still for 1 hour until the liquid is colorless and decolorized The medicinal solution was loaded into a D101 macroporous resin column, eluted with water, the eluate was collected, and concentrated under reduced pressure to a relative density of 1.0-1.2 to obtain a fine paste of cockroach extract.

Embodiment 2

[0018] Dried cockroaches are crushed into coarse powder, extracted with 10 times the weight ratio of 95% ethanol under heat reflux for 10 hours, and the filtrate is concentrated under reduced pressure at 80°C to a relative density of 1.0-1.2 to obtain a crude paste, which is poured into an oil-water separator , add 10 times the weight of purified water and stir well, let it stand for 24 hours, remove the bottom sediment and upper layer of grease, collect the brown liquid in the middle layer, then add activated carbon, stir well and stand still for 2 hours until the liquid is colorless, decolorize the liquid Put it into a D101-1 type macroporous resin column, elute with water, collect the eluate, concentrate under reduced pressure to a relative density of 1.0-1.2 to obtain a fine extract of cockroaches.

Embodiment 3

[0020] Crush 1000g of dried cockroaches into coarse powder, heat to 70°C with 8 times the weight ratio of 80% ethanol to extract for 9 hours, the filtrate is concentrated under reduced pressure to a relative density of 1.0-1.2 to obtain a crude paste, and the crude paste is introduced into oil-water separation Add 8 times the weight of purified water to fully stir, let it stand for 18 hours, remove the bottom sediment and upper layer of grease, collect the brown liquid in the middle layer, then add activated carbon, stir fully and stand still for 1.5 hours until the liquid is colorless; The solution was loaded into a D1300 macroporous resin column, eluted with water, and the eluate was collected, concentrated under reduced pressure to a relative density of 1.0-1.2 to obtain a fine extract of cockroaches.

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PUM

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Abstract

The invention provides a cockroach extractive and a prepared oral care composition as well as a preparation method and applications. The preparation of the cockroach extractive comprises the following steps: heating, refluxing and extracting coarse powder of dried cockroach with 70%-95% ethanol, filtering, and concentrating while decompressing to obtain a crude paste; carrying out oil-water separation on the crude paste; removing the sediment at the bottom layer and grease at the upper layer; collecting brown liquid medicine at the middle layer; then adding active carbon for decolorizing, filling to a macroporous resin column, and eluting with water; and collecting eluate, and concentrating while decompressing to obtain cockroach extractive refined paste. The oral care composition comprises 0.1-10% of cockroach extractive, 0.5-1.5% of carboxymethylcellulose, 15-25% of glycerin, 0.1-0.3% of methyl parahydroxybenzoate, 0.05-0.15% of propyl p-hydroxybenzoate, 0.3-1.0% of sodium lauryl sulfate, 35-45% of calcium hydrogen phosphate dihydrate, 3-8% of anhydrous dicalcium phosphate, 3-8% of silicon dioxide, 0.1-0.3% of saccharin, and 1.0-1.5% of essence. The oral care composition is usedfor preventing and treating gum bleeding, resisting inflammation, and repairing canker sore.

Description

technical field [0001] The invention belongs to the technical field of extraction and pharmacy from cockroaches, and in particular relates to a biologically active substance extracted from cockroaches for preparing an oral care composition. The composition is used for preventing and curing gingival bleeding, anti-inflammation and repairing oral ulcers. Background technique [0002] The cockroach, also known as the American cockroach (commonly known as the cockroach), is the largest in the family Blatella, with an adult body length of 29-35 mm. The epidermis of the cockroach contains sclera and chitin, elements such as bromine, zinc, nickel, manganese, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, and magnesium. Thirteen kinds of amino acids can be obtained by hydrolysis of the muscles, and there are also micronutrients stored in the body. Vitamins B1, B2, niacin and ascorbic acid, etc. Lymph contains trehalose, trehalase, glycoprotein, inositol, protocat...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K35/64A61K8/98A61P1/02A61P29/00A61Q11/00
Inventor邵维在李筱玲万德生段兆炜吴建忠
OwnerYUNNAN TENGCHONG PHARMA FACTORY