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Applications of gingko extractive in preparing external preparation for treating venereal disease, gynecopathy and perianal diseases

A technology of ginkgo extract and external preparation, which is applied in the field of biomedicine, can solve the problems of ginkgo extract, side effects, and easy recurrence, etc., and achieve the effect of safe use, no side effects, and no skin irritation

Inactive Publication Date: 2012-01-04
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of these diseases are treated with antibacterial drugs, antiviral drugs or antifungal drugs, as well as corticosteroid hormones and immunosuppressants. Although these drugs have a temporary effect, they are slow to take effect and easy to relapse after drug withdrawal; side effect
There is no report on the use of ginkgo extract in the preparation of external preparations for the treatment of venereal diseases, gynecological diseases and perianal diseases

Method used

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  • Applications of gingko extractive in preparing external preparation for treating venereal disease, gynecopathy and perianal diseases
  • Applications of gingko extractive in preparing external preparation for treating venereal disease, gynecopathy and perianal diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0017] The ginkgo fruit outer testa is peeled off, dried in the sun, and crushed with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, and extract for 4 hours each time . After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum-dried at 60°C to obtain Ginkgo biloba extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water.

[0018] Preparation of the gel: Sprinkle 10 g of Carbopol on the surface of 500 ml of distilled water, and swell overnight. Weigh 60 g of glycerin and 120 ml of propylene glycol, respectively add them to the swollen Carbopol, and grind them evenly to obtain a transparent g...

Embodiment 2

[0020] The ginkgo fruit outer testa is peeled off, dried in the sun, and crushed with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add distilled water with a solid-liquid ratio of 1:6 (W / V), and stir and extract twice at a water bath temperature of 60° C., each extraction time is 4 hours. After the leaching is finished, filter with a suction filter to collect the filtrate. The filtrate was concentrated. Vacuum-dried at 60°C to obtain Ginkgo biloba extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water.

[0021] Preparation of ointment: Take 5 g of the above-mentioned ginkgo extract extract, dissolve it in 100 ml of 95% ethanol solution, add 50 ml of triethanolamine therein, and heat to 70° C. 300g of paraffin, 300g of stearic acid, and 100ml of propylene glycol were respectively added and stirred to melt, supplemented with distilled water to a sufficient amount of 1000g, and stirred evenly to a pa...

Embodiment 3

[0023] The ginkgo fruit outer testa is peeled off, dried in the sun, and crushed with a pulverizer. Accurately take a certain amount of pulverized Ginkgo testa, add 80% petroleum ether with a material-to-liquid ratio of 1:6 (W / V), and stir and extract 2 times at a water bath temperature of 60 ° C, each extraction time is 4 Hour. After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum-dried at 60°C to obtain Ginkgo biloba extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water.

[0024] The preparation of tincture: get above-mentioned ginkgo extract extract 100g, dissolve in 600ml 95% ethanol solution, then add triethanolamine 50ml, propylene glycol 200ml stirring therein respectively, make up 95% ethanol solution to sufficient amount...

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Abstract

The invention relates to applications of a gingko extractive in preparing an external preparation for treating venereal disease, gynecopathy and perianal diseases. The gingko extractive can be obtained from extractives of the parts of leaves, fruit, testa, rhizome and the like of gingko through a chemical separation method, and the extractive solvents can be organic solvents of alcohol, water, ethyl ether, petroleum ether and the like. The venereal disease is infectious and inflammatory genital disease. The medicament and disinfectant external preparation containing the gingko extractive for treating venereal disease, gynecopathy and perianal diseases comprises 0.001-80% of gingko extractive (in percentage by weight) and pharmaceutically common external preparation media or acceptable carriers; and the preparation is any external dosage form in pharmaceutics. The clinical test result shows that the gingko extractive provided by the invention has an obvious treatment effect on multiple venereal diseases, gynecopathy and perianal diseases, the effective rate can reach 100%, and the gingko extractive is safe and has no toxic and side effects in use.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the use of ginkgo extract in preparing external preparations for treating venereal diseases, gynecological diseases and perianal diseases. Background technique [0002] Sexually transmitted diseases, gynecological diseases and perianal diseases are one of the most common clinical diseases. These diseases last for a long time and are easy to recur, which brings pain to patients and seriously affects their physical and mental health. Such diseases are mostly related to genital and surrounding resident pathogen infections, such as gonorrhea, Trichomonas vaginalis, Candida albicans, Chlamydia, herpes virus, human papillomavirus (HPV), Treponema pallidum, pubic lice and other infections, causing multiple Various sexually transmitted diseases such as gonorrhea, syphilis, genital warts, genital herpes, chancroid, genital chlamydia infection, pubic lice, etc.; gynecologica...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P31/04A61P31/10A61P31/12A61P31/20A61P31/22A61P33/02A61P15/00A61P17/00A61K125/00A61K127/00A61K131/00
Inventor 王青雷红
Owner 王青
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