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Dipeptide having antiatherosclerotic action

A technology for atherosclerosis, side effects, applied in the field of compositions

Inactive Publication Date: 2012-01-04
FUJI OIL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the distance between the effective amount of a calcium channel blocker as a vasodilator and the amount of side effects that cause increased heart weight is rarely suspected to be a problem, the use of calcium channel blockers as an anti-inflammatory When the atherosclerotic agent is used, as mentioned above, the difference between the effective amount of the anti-atherosclerotic agent and the amount of the side effect causing the increase of the heart weight is only about 3.3 times, therefore, the calcium channel blocker Problematic when used as an anti-atherosclerotic agent

Method used

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  • Dipeptide having antiatherosclerotic action
  • Dipeptide having antiatherosclerotic action
  • Dipeptide having antiatherosclerotic action

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Experiment 1 (Examples 1-2, Comparative Example 1)

[0037]"Anti-atherosclerotic effect of the dipeptide Trp-His"

[0038] Acquisition of peptides and reagents

[0039] Trp-His was synthesized by the Fmoc solid-phase synthesis method (manufactured by Kokusai Chemical Co., Ltd.). For other reagents, reagent grade materials were used.

[0040] As animal test subjects, apo-E knockout mice (male 8-18 weeks old) purchased from Jackson Laboratory (Bar Harbor, ME, USA) and bred at the Institute of Animal Experiments, Faculty of Medicine, Kyushu University were used. These were divided into 3 groups, and the feed shown in Table 1 was fed for 9 weeks. There was no significant difference in the circumference of the mice between the groups. (Comparative Example 1: 15.0±0.8, Example 1: 14.3±1.2, Example 2: 14.6±1.3).

[0041] Table 1: Feed formulation

[0042]

[0043] Trp-His was administered by dissolving 10 to 100 mg / kg of Trp-His in 1 ml of deionized water based on the...

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Abstract

Disclosed is an antiatherosclerotic agent which can be used, without fear of influencing the heart, for a patient suffering from atherosclerosis in combination with a cardiac disease. Also disclosed is a food inherently having the aforesaid function. Specifically disclosed are an antiatherosclerotic agent which comprises a dipeptide Trp-His and / or a salt thereof as the active ingredient, and a food inherently having the aforesaid function.

Description

technical field [0001] The present invention relates to a dipeptide represented by Trp-His or a salt thereof as an active ingredient, which can be used even when accompanied by heart disease where calcium antagonists are contraindicated, and has the ability to prevent or inhibit the development of atherosclerosis Compositions such as health foods, functional foods, and pharmaceuticals. Background technique [0002] Calcium channel blockers are agents that have vasodilation and even vasodilation effects, and their effects on atherosclerosis are also documented. For example, Non-Patent Document 1 describes the anti-atherosclerotic effect of azelnidipine, which is a representative calcium channel blocker. The minimum effective dose where the effect can be confirmed is 3 mg / kg / day described here, which is a very large value compared with the 8 to 16 mg / day required for the vasodilator action (for a patient with a body weight of 60 kg). According to the information about Azhedi...

Claims

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Application Information

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IPC IPC(8): A61K38/00A61P9/10
CPCA61K38/05A61P9/10A61K38/00
Inventor 松井利郎松本清佐藤匡央今泉胜己中森俊宏
Owner FUJI OIL CO LTD
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