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Method for extraction and purification of corn silk general flavone, and use of corn silk general flavone

A purification method and technology for total flavonoids are applied in the field of production technology for extracting and purifying flavonoids, which are hypolipidemic substances.

Inactive Publication Date: 2012-01-11
ANHUI AGRICULTURAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many studies on the clinical and application effects of corn silk, but there are very few studies on its active ingredients

Method used

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  • Method for extraction and purification of corn silk general flavone, and use of corn silk general flavone
  • Method for extraction and purification of corn silk general flavone, and use of corn silk general flavone
  • Method for extraction and purification of corn silk general flavone, and use of corn silk general flavone

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Experimental program
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Embodiment Construction

[0015] 1) Obtaining corn silk

[0016] Pick from a corn planting farmland in Huatuo Town, Haozhou, Anhui (corn plants grow to maturity, corn silk is brown, water content is about 20%), the corn silk that picks back is baked in 70 ℃ oven for 6 hours, make If it loses free water, use it within a week; or bake it at 102°C for 10 hours to remove bound water, and use it for a long time.

[0017] 2) Resin pretreatment

[0018] Fully soak in ethanol with a concentration of 50-60%, wash with ethanol until the eluate is free from white turbidity, add appropriate amount of water, wash with deionized water, and finally soak in 5% HCl solution for 3 hours, wash with deionized water until the pH value is neutral, Then soak in 5% NaOH solution for 3h, and wash with deionized water until the pH value is neutral.

[0019] 3) Extraction process of flavonoids

[0020] Weigh 20g of corn silk with a balance, pour it into a 1L beaker, add 400mL of ethanol solution with a volume concentration of...

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Abstract

The invention relates to a method for extraction and purification of corn silk general flavone, and a use of corn silk general flavone. The method adopts corn silk as a raw material and comprises the following steps of raw material snipping, extraction, condensation and purification. The method is characterized in that the extraction step comprising carrying out extraction by an ethanol solution with concentration of 60% at a temperature of 60 DEG C for 3 hours, wherein a solid-liquid ratio is 1: 20; and the purification step comprising purifying crude extract by a HPD-100 macroporous resin. The prepared corn silk general flavone is added into rabbit forage according to an addition ratio of 2% and has substantial effects of reducing blood fat, wherein P is less than or equal to 0.1. The method has simple operation steps and low costs, is suitable for practical production operation, and can develop integrated utilization of agricultural and sideline products and promote economic prosperity in the country. The method for extraction and purification of corn silk general flavone belongs to the field of corn silk general flavone research and lays the foundation for good development and utilization of corn silk and research of clinical curative effect basis of corn silk general flavone.

Description

technical field [0001] The invention relates to a process for extracting high-content medicinal ingredients from corn silk, in particular to a production process for extracting and purifying flavonoids, a substance that lowers blood fat, from the style and stigma of maize, a plant belonging to the genus Gramineae, corn silk. Background technique [0002] Corn silk (Stigma maydis) is the style and stigma of corn (Zea mays L.). It contains a variety of chemical components, such as volatile oil, saponins, alkaloids, total flavonoids, polypentose, allantoin, organic acids, etc. Its mild taste, flat nature, diuresis, purging heat, calming the liver, and benefiting the choleresis can be used to treat nephritis, gallstones, diabetes, jaundice, measles, chylous hematuria, blood jump and other diseases. Modern pharmacological studies have proved that corn silk has a significant diuretic effect [ , lowering blood sugar, lowering blood pressure, inhibiting bacteria, enhancing immunit...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P3/06A61K131/00
Inventor 王在贵陈佳佳徐双贵
Owner ANHUI AGRICULTURAL UNIVERSITY
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