Veterinary long-acting cefquinome sulfate injection and preparation method thereof

Abstract

The invention relates to the technical field of animal medicine, and particularly discloses veterinary long-acting cefquinome sulfate injection and a preparation method thereof. 100 mL of the injection comprises 2.5-7.5 g of cefquinome sulfate, 0.2-0.4 g of suspending agents, 0.4 g of bacteriostatic agents, 0.3 g of emulsion dispersants, and the balance of solvents. The preparation method comprises the following steps: firstly adding cefquinome sulfate into the solvent, stirring for well mixing; adding the suspending agent into the solvent with a temperature of 90-100 DEG C for dissolution; cooling the dissolved solution in the second step to room temperature, adding the suspension under stirring in the first step, uniformly stirring; adding the bacteriostatic agent and the emulsion dispersant in to the suspension in the third step, fully stirring; finally adding residual amount of the solvent, uniformly stirring, orderly adding the mixture into a high-speed shearing dispenser and a colloid mill, performing radiation sterilization to prepare the product. When the product is used in pigs by intramuscular injection, the elimination half life is long; the effective action time of themedicine in the body is prolonged; and the drug administration time is reduced.

Description

technical field [0001] The invention relates to the technical field of animal medicines, in particular to a veterinary long-acting cefquinome sulfate injection and a preparation method thereof. Background technique [0002] Cefquinome is the fourth-generation cephalosporin antibiotic for animals. It is a broad-spectrum and highly effective cephalosporin antibiotic. Compared with the third-generation cephalosporin, it has a wider antibacterial spectrum and stronger bactericidal effect. Its intrinsic antibacterial activity is stronger than that of the first three generations of cephalosporins. Compared with the first three generations of cephalosporins, the dosage of the fourth generation of cephalosporins is small (3-5 mg per kg for poultry, 2 mg per kg for livestock, and 1 mg per kg for cattle and sheep); Strong sensitivity; long plasma half-life, no nephrotoxicity. It has a strong killing effect on Staphylococcus aureus, Streptococcus, Pseudomonas aeruginosa, Enterobacteri...

AI Technical Summary

Problems solved by technology

[0003] The shortcoming of existing cefquinome sulfate medicine is that action time is short, and its medication method is to inject once a day basically, use continuously for 3 to 5 days, in order to reduce the waste of manpower and financial resources of farms caused by frequent injection of cefquinome , and try to avoid the animal stress response caused by multiple administrations, the researchers in the field of veterinary medicine urgently need to develop a long-acting cefquinome preparation that is convenient for administration for the aquaculture industry in my country, and provide convenience for clinical medication

Images