Veterinary long-acting cefquinome sulfate injection and preparation method thereof

A technology for cefquinoxime sulfate and injection, which is applied in the field of veterinary long-acting cefquinoxime sulfate injection and its preparation, can solve problems such as short action time, achieve long half-life, improve fluidity, and improve suspension adhesion effect Effect

Active Publication Date: 2012-01-18
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The shortcoming of existing cefquinome sulfate medicine is that action time is short, and its medication method is to inject once a day basically, use continuously for 3 to 5 days, in order to reduce the waste of manpower and financial resources of farms caused by frequent injection of cefquinome , and try

Method used

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  • Veterinary long-acting cefquinome sulfate injection and preparation method thereof
  • Veterinary long-acting cefquinome sulfate injection and preparation method thereof
  • Veterinary long-acting cefquinome sulfate injection and preparation method thereof

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Embodiment 1-8

[0031] A kind of veterinary long-acting cefquinome sulfate injection, every 100mL of this injection is composed as follows:

[0032]

[0033] Wherein the weight ratio of hydrogenated castor oil and soybean lecithin in the suspending agent of embodiment 1-3, 4-6, 7-8 is respectively 2: 3, 2: 5, 2: 4.

[0034] The preparation method step of the injection of above-mentioned embodiment 1-8 is as follows:

[0035] (1) Add the cefquinome sulfate bulk drug into the injection-grade solvent or composite solvent, and magnetically stir to make it fully mixed;

[0036] (2) Add the suspending agent to the solvent at 90-100°C to dissolve;

[0037] (3) Add the solution in step (2) to the suspension in stirring step (1) after being cooled to room temperature, and stir evenly;

[0038] (4) Add bacteriostat and emulsifying dispersant to the suspension of step (3) again, fully stir;

[0039] (5) Add the remaining amount of injection-grade solvent or compound solvent, stir and mix for 30 mi...

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Abstract

The invention relates to the technical field of animal medicine, and particularly discloses veterinary long-acting cefquinome sulfate injection and a preparation method thereof. 100 mL of the injection comprises 2.5-7.5 g of cefquinome sulfate, 0.2-0.4 g of suspending agents, 0.4 g of bacteriostatic agents, 0.3 g of emulsion dispersants, and the balance of solvents. The preparation method comprises the following steps: firstly adding cefquinome sulfate into the solvent, stirring for well mixing; adding the suspending agent into the solvent with a temperature of 90-100 DEG C for dissolution; cooling the dissolved solution in the second step to room temperature, adding the suspension under stirring in the first step, uniformly stirring; adding the bacteriostatic agent and the emulsion dispersant in to the suspension in the third step, fully stirring; finally adding residual amount of the solvent, uniformly stirring, orderly adding the mixture into a high-speed shearing dispenser and a colloid mill, performing radiation sterilization to prepare the product. When the product is used in pigs by intramuscular injection, the elimination half life is long; the effective action time of themedicine in the body is prolonged; and the drug administration time is reduced.

Description

technical field [0001] The invention relates to the technical field of animal medicines, in particular to a veterinary long-acting cefquinome sulfate injection and a preparation method thereof. Background technique [0002] Cefquinome is the fourth-generation cephalosporin antibiotic for animals. It is a broad-spectrum and highly effective cephalosporin antibiotic. Compared with the third-generation cephalosporin, it has a wider antibacterial spectrum and stronger bactericidal effect. Its intrinsic antibacterial activity is stronger than that of the first three generations of cephalosporins. Compared with the first three generations of cephalosporins, the dosage of the fourth generation of cephalosporins is small (3-5 mg per kg for poultry, 2 mg per kg for livestock, and 1 mg per kg for cattle and sheep); Strong sensitivity; long plasma half-life, no nephrotoxicity. It has a strong killing effect on Staphylococcus aureus, Streptococcus, Pseudomonas aeruginosa, Enterobacteri...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61K47/44A61K47/34A61K47/24A61P31/04
Inventor 张卫元陈翠兰操继跃刘国庆张永丹肖飞张翠平
Owner 武汉回盛生物科技股份有限公司
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