Preparation method and application of multiflower knotweed vine polysaccharide chelate zinc

A technology of Shouwuteng and chelated zinc, applied in the field of medicine, can solve problems such as low absorption rate and loss, and achieve the effects of simple method, low absorption rate and abundant raw materials.

Inactive Publication Date: 2012-02-15
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past and now, zinc supplements such as zinc sulfate and simple zinc gluconate are mostly used in clinical zinc supplementation. Most of them are absorbed in the form of ions in the body. A large amount of loss is caused by the formation of insoluble matter; on the one hand, due to factors such as insufficient binding protein, the absorption rate is low
[0003] Polysaccharides are a class of carbohydrates with large molecular weight and complex structure. Studies have shown that polysaccharides have immune regulation, anti-virus and anti-cancer effects. Due to the high content of polysaccharides, the preparation process is relatively simple, and it is easy to be absorbed by the body, so its It is of great application value in the industries of medicine, health and food, but there is no report on the preparation and application of polysaccharide chelated zinc from Polygonum multiflorum

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Weigh 400g of dried Shouwu vine powder, add water to extract 3 times at 90°C, 3 hours each time, add 4000g (or 4000ml) of water 10 times the weight of the powder for the first time, add the weight of the powder for the second and third times 3200g (or 3200ml) of 8 times water, filter, combine the filtrates, concentrate to a solution with a relative density of 1.1, and obtain the polysaccharide extract of Polygonum multiflorum, then add an equivalent amount of 0.5mol / L zinc sulfate solution, stir evenly, and use 2mol / L sodium hydroxide to adjust the pH of the solution to 6.0, react at 80°C for 2.5 hours, dialyze with a dialysis bag with a molecular weight cut-off of 8000-14000, concentrate the dialysate to a solution with a specific gravity of 1.3, add 95% ethanol to adjust the alcohol content to 80 %, let stand overnight, centrifuge, dry the precipitate, and pulverize it to obtain polysaccharide chelated zinc from Polygonum multiflorum.

Embodiment 2

[0016] Weigh 600g of dried Shouwu vine powder, add water and extract twice at 80°C for 3 hours each time, add 5400g (or 5400ml) of water 9 times the weight of the powder for the first time, add 5400g of water 9 times the weight of the powder for the second time (or 5400ml), filter, combine the filtrates, concentrate to a solution with a relative density of 1.2, and obtain the polysaccharide extract of Polygonum multiflorum, then add an equivalent amount of 0.5mol / L zinc sulfate solution, stir evenly, and oxidize with 2mol / L hydroxide Adjust the pH of the solution to 7 with sodium, react at 90°C for 2 hours, dialyze with a dialysis bag with a molecular weight cut-off of 8000-14000, concentrate the dialysate to a solution with a specific gravity of 1.2, add 95% ethanol to adjust the alcohol content to 85%, and let stand overnight , centrifuged, dried the precipitate, and pulverized to obtain polysaccharide polysaccharide chelated zinc.

Embodiment 3

[0018] Weigh 1000g of dried Shouwu vine powder, add water to extract 4 times at 100°C, 1.5 hours each time, add 10000g (or 10000ml) of water 10 times the weight of the powder for the first time, add the weight of the powder for the second and third times 9 times the water 9000g (or 9000ml), the fourth time add 8000g (or 8000ml) of water 8 times the weight of the powder, filter, combine the filtrate, concentrate to a solution with a relative density of 1.3 to obtain the polysaccharide extract of Polygonum multiflorum, then add Amount of 0.5mol / L zinc sulfate solution, stir evenly, adjust the pH of the solution to 8 with 2mol / L sodium hydroxide, react at 70°C for 3 hours, dialyze with a dialysis bag with a molecular weight cut-off of 8000-14000, and concentrate the dialysate to For a solution with a specific gravity of 1.3, add 95% ethanol to adjust the alcohol content to 90%, let it stand overnight, centrifuge, dry the precipitate, and pulverize it to obtain polysaccharide polys...

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PUM

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Abstract

The invention relates to a preparation method and application of multiflower knotweed vine polysaccharide chelate zinc. The problems of preparation of the multiflower knotweed vine polysaccharide chelate zinc and application thereof in preparation of health-care products and medicaments can be effectively solved. The method comprises the following steps of: extracting multiflower knotweed vine powder in water in a weight ratio of 1: (8-10) at the temperature of 80 and 100 DEG C for 2 to 4 times and for 1.5 to 3 hours every time, filtering, combining the filtrate, performing concentration tillthe relative density is 1.1 to 1.3, and obtaining multiflower knotweed vine polysaccharide concentrate; mixing the multiflower knotweed vine polysaccharide concentrate and zinc sulfate solution in equal volume, stirring the solution uniformly, regulating the pH value to be between 6.0 and 8.5 by using sodium hydroxide solution, reacting for 2 to 3 hours at the temperature of between 70 and 90 DEGC, and obtaining multiflower knotweed vine polysaccharide chelate zinc solution; and dialyzing the multiflower knotweed vine polysaccharide chelate zinc solution, adding 95 percent ethanol into the dialyzed solution till the ethanol content reaches 80 to 90 percent, performing standing and alcohol precipitation for 10 to 24 hours, filtering, obtaining sediment, drying and crushing, and thus obtaining the multiflower knotweed vine polysaccharide chelate zinc. The method is simple, the raw materials are rich, the product has wide application, the problem of low absorption of the conventional zinc supplementing product is solved, and the product has the effect of improving the immunity of the body and is an innovation of Chinese medicaments.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method and application of Polygonum multiflorum polysaccharide chelated zinc. Background technique [0002] Zinc is a component or coenzyme of six major enzymes and 200 metalloenzymes in the human body. It plays a wide range of roles in systemic metabolism, such as participating in the synthesis of nucleic acids and proteins, cellular and humoral immune processes, and energy metabolism. It is an essential trace element for the human body. In the past and now, zinc supplements such as zinc sulfate and simple zinc gluconate are mostly used in clinical zinc supplementation. Most of them are absorbed in the form of ions in the body. The formation of insoluble matter leads to a large amount of loss; on the one hand, it is affected by factors such as insufficient binding protein, and the absorption rate is low. [0003] Polysaccharides are a class of carbohydrates with large mol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A23L1/09A61K31/715A61P3/12A61P1/14A61P37/04
Inventor 刘富岗杨云卫冰
Owner HENAN UNIV OF CHINESE MEDICINE
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