Method for preparing propionyl levocarnitine hydrochloride and application of medicaments thereof

A technology of propionyl-levocarnitine hydrochloride and propionic acid, which is applied in the field of preparation of propionyl-levocarnitine hydrochloride, can solve problems such as difficult operation, and achieve the effects of easy operation, mild conditions and improved efficiency
CN102391141AInactive Publication Date: 2012-03-28LEES PHARMA HONG KONG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
LEES PHARMA HONG KONG
Publication Date
2012-03-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for preparing propionyl levocarnitine hydrochloride and application of medicaments thereof. The method comprises the following steps of: (1) mixing and stirring propionic acid and levocarnitine inner salt to prepare propionic acid solution of the levocarnitine inner salt, wherein a mass ratio of the propionic acid to the levocarnitine inner salt is 1:(0.5-1.5); (2) mixing and stirring the propionic acid and propionyl chloride to prepare an acylated reagent, wherein a mass ratio of the propionic acid to the propionyl chloride is 1:(1.5-10); and (3) mixing the propionic acid solution of the levocarnitine inner salt and the acylated reagent, and performing acidylation reaction to obtain the propionyl levocarnitine hydrochloride. The method is mild in condition, safe in reaction, easy to operate and low in cost, and waste gas is not generated. The medicaments which take the propionyl levocarnitine hydrochloride as active ingredients are used for treating peripheral arterial diseases and chronic congestive heart failure to enhance athletic ability, and have a good effect.
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Description

technical field

[0001] The invention relates to the technical field of medicines, in particular to a preparation method of propionyl levocarnitine hydrochloride and its medicine application. Background technique

[0002] Peripheral arterial disease (PAD) is a chronic ischemic disorder of the extremities resulting from impaired metabolism and function of muscles. The damage process is divided into four phases by Fontain. Stage I manifests as subclinical changes in blood flow. Stage II is characterized by intermittent claudication (IC), where pain forces the patient to stop during periods of higher energy demands such as walking. Patients with stage III PAD have severely reduced blood flow causing pain at rest. In the most severe case (Stage IV), the patient develops nutritional impairment with leg ulcers and / or gangrene. In the United States, 9.6% of cardiovascular events are due to peripheral arterial disease (PAD) presenting as IC. It is directly related to 770,000 hos...

Claims

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