Application of mitoxantrone as lymph tracer

A mitoxantrone and tracer technology, which is applied in the field of pharmaceutical preparations, can solve the problems of residual preparation process at the injection site, slow tracer dyeing time, and large diffusion of surrounding tissues, etc., and achieves long-lasting blue dyeing, low price, less diffuse effect

Active Publication Date: 2012-04-04
SHENYANG PHARMA UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problems of slow staining time, short maintenance time, large diffusion of surrounding tissue, serious residue at the injection site and complicated preparation process of the existing tracers, and provides the application of mitoxantrone as a lymphatic tracer

Method used

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  • Application of mitoxantrone as lymph tracer
  • Application of mitoxantrone as lymph tracer
  • Application of mitoxantrone as lymph tracer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Example 1. Preparation of Mitoxantrone Hydrochloride Injection

[0071] 1.1 Prescription

[0072] Mitoxantrone Hydrochloride 100g

[0073] Sodium metabisulfite 5 g

[0074] 0.1mol / L hydrochloric acid to adjust the pH to about 3.5

[0075] Add water for injection to 1000ml

[0076] Made of 200

[0077] 1.2 Preparation process

[0078] Contains the main drug 100mg / mL, and the solvent is water for injection. The method of dissolution or dilution can be used for preparation, the main drug is dissolved in an appropriate amount of water for injection, ultrasonically dissolved, an appropriate amount of hydrochloric acid is added to adjust the pH to about 3.5, sodium metabisulfite is added to dissolve, 0.1% activated carbon for needles is added, and stirred at room temperature for 30 minutes. Then use a 0.8μm microporous membrane to remove carbon, 0.45μm microporous membrane to fine ...

Embodiment 2

[0079] Example 2 Mitoxantrone Hydrochloride Powder Injection

[0080] 2.1 Prescription

[0081] Mitoxantrone Hydrochloride 10mg

[0082] Mannitol 1000mg

[0083] Creatinine 10mg

[0084] Add water for injection to 500ml

[0085]

[0086] Made of 100

[0087] 2.2 Preparation process

[0088] Dissolve the above-mentioned components with appropriate amount of water for injection, filter aseptically, and divide them into ampoules, each 5ml, freeze-dry, seal, and check for air leakage.

Embodiment 3

[0089] Embodiment 3 Mitoxantrone hydrochloride emulsion

[0090] 3.1 Prescription

[0091] Mitoxantrone Hydrochloride 5%

[0092] Soybean Oil 50%

[0093] Span 80 – Tween 80 (HLB=8) 35%

[0094] Transcutol P 5.4 %

[0095] 5% glucose solution 3.6 %

[0096] Total 100.0 g

[0097] 3.2 Preparation process

[0098] Precisely weigh the prescribed amount of mitoxantrone hydrochloride and fully dissolve it in the mixture of Transcutol P, Span80-Tween80 (HLB=8) and 5% glucose solution, stir at 45°C for 20 min, add the prescribed amount of soybean oil , stirred for 20 min, and mixed evenly to obtain mitoxantrone hydrochloride water-in-oil microemulsion.

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PUM

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Abstract

The invention provides an application of mitoxantrone and salt thereof as a lymph tracer (such as hydrochloric acid mitoxantrone, oxalic acid mitoxantrone, sulfuric acid mitoxantrone, phosphoric acid mitoxantrone, acetic acid mitoxantrone, citric acid mitoxantrone and the like). The mitoxantrone and salt thereof can be used for preparing injection, powder injection, emulsion, liposome, nanoparticle, microballoon and the like. The mitoxantrone and salt thereof not only can be used for killing malignant tumor cells, but also the blue dye feature can be used as the lymph tracer applied to lymphadenectomy in cancer operative treatment, which is suitable for treating stomach cancer, breast cancer, intestinal cancer, cervical carcinoma, testis cancer and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to the application of mitoxantrone as a lymphatic tracer. Background technique [0002] Cancer is a major killer that threatens the health of all human beings. There are 8 million new cancer patients every year in the world. A research report released by the International Cancer Research Center of the World Health Organization said that according to the current trend of cancer incidence, in 2020 the world's The incidence of cancer will increase by 50%, and the number of new cancer patients worldwide will reach 15 million each year. Since the 1970s, cancer death has been continuously increasing in China. Currently, cancer death ranks first among all causes of death. Early detection and diagnosis of cancer can buy time for cancer treatment, which is of special significance to the lives of patients. Timely and thorough surgery to remove cancer cells is the key to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
Inventor 王淑君王敏许文程菲
Owner SHENYANG PHARMA UNIVERSITY
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