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Preparation method and application of atalantia buxjfolia extract

An extract, Dongfeng technology, applied in the field of medicine, can solve the problems such as unclear action mechanism and efficacy of Dongfeng orange, difficult quality control, etc., and achieve the effects of suitable promotion and application, low production cost and simple preparation method.

Inactive Publication Date: 2013-11-20
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, in the prior art including Dongfengju Oral Liquid, the mechanism of action and efficacy of Dongfengju are not clear, and the quality is difficult to control

Method used

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  • Preparation method and application of atalantia buxjfolia extract
  • Preparation method and application of atalantia buxjfolia extract
  • Preparation method and application of atalantia buxjfolia extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 Dongfeng orange extract

[0024] (1) Take Dongfeng orange medicinal material (the dry root and stem of Severinia buxifolia (Poir).Oliv.) are used in this embodiment), pulverize, take the coarse powder, and use a volume ratio concentration of 95% ethanol for reflux extraction, For the first time, 5 times the mass of the medicinal material was used for reflux extraction with ethanol, and for the second time, 3 times the mass of the medicinal material was used for reflux extraction, and each reflux extraction was 2 hours, and the second extraction was followed by standing and filtering;

[0025] (2) Merge the filtrate gained in step (1), and reclaim the solvent under conventional reduced pressure to obtain the total extract;

[0026] (3) Suspend the total extract obtained in step (2) with water (6 times the quality of the total extract), then use sherwood oil, chloroform, ethyl acetate and n-butanol (volume of extraction solvent: volume of w...

Embodiment 2

[0029] Application experiment of embodiment 2 Dongfeng orange extract

[0030] (1) Antitussive effect experiment

[0031] 1 Experimental materials

[0032] 1.1 Drugs

[0033] The Dongfeng orange extract prepared in Example 1 of the present invention, including petroleum ether extract, chloroform extract, ethyl acetate extract, n-butanol extract and water extract, were dispersed with 0.5% normal saline respectively to prepare Test solutions with different concentrations;

[0034] Ketraling Capsules (Guangzhou Baiyunshan Pharmaceutical Co., Ltd., batch number: 11100508);

[0035] 1.2 Experimental animals

[0036] SPF-grade Kunming mice, half female and half male, weighing 18-22 g, were provided by the Guangdong Experimental Animal Center, certificate number: SCXK (Guangdong) 2008-0002.

[0037] 2 Experimental methods

[0038] 2.1 Study on the antitussive effect of Dongfengju on mice (concentrated ammonia water spray method)

[0039] Get 98 Kunming mice, divide into 7 grou...

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Abstract

The invention discloses a preparation method, application and an extract of an atalantia buxjfolia extract. In the invention, an ethanol extract of atalantia buxjfolia coarse powder is extracted by using chloroform or normal butanol and then is decompressed and recovered to obtain a chloroform extract or a normal butanol extract. The atalantia buxjfolia extract has good activity of relieving cough and reducing sputum and can be applied to preparation of a medicament for relieving cough and reducing sputum. The preparation method of the atalantia buxjfolia extract is simple, is convenient and rapid to operate, is easy to realize quality control, has low production cost, is beneficial to industrial production and is suitable to be popularized and applied.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method and application of Dongfeng orange extract. Background technique [0002] Cough, sputum, and wheezing are common symptoms of respiratory diseases, especially bronchial asthma. In the cold winter and in the north, the incidence rate is higher and the course of disease is long. It can be as short as a few years or as long as decades. Especially the elderly. Coupled with environmental pollution, smoking and stimulation of physical and chemical factors, the incidence rate is higher, which seriously endangers the health of the people and the labor force. At present, the progress of therapeutic drug research in this field is slow, and there is no ideal drug yet. Common cough medicines such as ephedra preparations have many adverse reactions, such as increased blood pressure, insomnia, headache, and tachyphylaxis. Western medicines such as aminophyll...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/75A61P11/10A61P11/14A61K125/00A61K135/00
Inventor 沈志滨尹永芹陈艳芬黄峰陶曙红崔红花
Owner GUANGDONG PHARMA UNIV