Synthesis method of gemcitabine hydrochloride

A technology of gemcitabine hydrochloride and its synthetic method, which is applied in the field of synthesis, can solve the problems of high cost, easy transformation of configuration, unfavorable batch production, etc., and achieve the effect of easy operation and simple method

Inactive Publication Date: 2012-04-18
JIANGSU QINGJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

In summary, it describes two methods for producing certain chemical compounds: one involves synthesizing these molecules in large amounts at once while maintaining their desired properties; another approach uses specific configurations or precursors that are stable during storage without losing its original structure when exposed to strong acid solutions like hydrochloride gas. These technical results help create more efficient ways to produce complex organosilicon materials with improved performance characteristics such as solubility, stability against decomposition over time, etc., compared to existing techniques involving multiple steps.

Problems solved by technology

This patented technical problem addressed by this patents relates to improving gemitabinuxydro chloride (Gemacid) manufacturing processes while reducing their costs or increasing yields compared with current methods like chemical reactions involving expensive starting materials.

Method used

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  • Synthesis method of gemcitabine hydrochloride

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Embodiment

[0033] Embodiment: Synthesize gemcitabine hydrochloride according to the following steps

[0034] Step 1: Synthesis of GH-2: Add ethane (10L), propane (10L), D-mannitol (10KG, 54.9mol), anhydrous tin dichloride (10g, 0.05mol) into the reaction pot ; Heating to reflux, the reaction solution was clarified after 1 hour, and continued to react for 0.5 hours; cooled to 25°C, added pyridine (13ml), acetic anhydride (7ml), and stirred for 10 minutes; the solvent was evaporated under reduced pressure, and the internal temperature was controlled at 70 Below ℃; After evaporating to dryness, add dichloromethane to the residual liquid, stir for 30 minutes, and let it stand overnight to obtain GH-2 solution; the next day, suction filter, and the filtrate is pumped into the GH-3 reaction pot;

[0035] ;

[0036] Step 2: Synthesis of GH-3: Heat the GH-2 (6kg, 22.9mol) solution to 20°C, add sodium periodate (12.5kg, 58.6mol) under stirring; slowly add water dropwise, dropwise for half an ...

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Abstract

The invention discloses a synthesis method of gemcitabine hydrochloride. The gemcitabine hydrochloride has a molecular formula of C9H11F2N3O4.HCl, the molecular weight of 299.66 and a chemical abstracts service (CAS) registry number of 122111-03-9. The synthesis method of gemcitabine hydrochloride has the advantages of high yield, easiness of preparation of gemcitabine hydrochloride GH-7 having a single configuration, convenience of operation, and relatively stable configuration.

Description

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Claims

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Application Information

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Owner JIANGSU QINGJIANG PHARMA
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