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Anti-inflammation and anti-allergy canker sore treating medicament and preparation method thereof

An oral ulcer and anti-allergy technology, which is applied in the direction of medical formula, digestive system, drug combination, etc., can solve problems such as unbearable pain, inconvenience in life and work, affecting diet and speaking, and achieve good therapeutic effect and good quality stability , good flexibility

Active Publication Date: 2013-09-25
四川梓橦宫药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the onset, there is a severe burning sensation on the ulcer surface, the pain is unbearable, and it affects eating and speaking, which brings a lot of inconvenience to life and work

Method used

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  • Anti-inflammation and anti-allergy canker sore treating medicament and preparation method thereof
  • Anti-inflammation and anti-allergy canker sore treating medicament and preparation method thereof
  • Anti-inflammation and anti-allergy canker sore treating medicament and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A new anti-inflammatory and anti-allergic film for treating oral ulcers, the formula is as follows:

[0034]

[0035] The preparation method is as follows:

[0036] The main drug amlexanox was passed through a 100-mesh sieve for later use, and polyvinyl alcohol and sodium carboxymethylcellulose were passed through a 60-mesh sieve for later use. Weigh the prescribed amount of polyvinyl alcohol and sodium carboxymethylcellulose into a beaker, add an appropriate amount of purified water to soak overnight, and make it fully expand into a glue. Heat the soaked polyvinyl alcohol on a water bath at 80-90°C to form a glue. Dissolve ethyl p-hydroxybenzoate into a solution with an appropriate amount of ethanol. Add amlexanox, polysorbate 80, glycerin, and ethyl p-hydroxybenzoate ethanol solution into the soaked sodium carboxymethylcellulose mucilage, and grind it evenly in a mortar. Mix the above two types of glue, add water to a total water volume of 86.6g, stir gently to ...

Embodiment 2

[0038] A new anti-inflammatory and anti-allergic film for treating oral ulcers, the formula is as follows:

[0039]

[0040] The preparation method is the same as in Example 1, wherein the total water consumption is 70.0 g.

Embodiment 3

[0042] A new anti-inflammatory and anti-allergic film for treating oral ulcers, the formula is as follows:

[0043]

[0044] The preparation method is the same as in Example 1, wherein the total water consumption is 180.0 g.

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Abstract

The invention discloses a novel anti-inflammation and anti-allergy canker sore treating film agent, which comprises amlexanox, polyvinyl alcohol, carboxymethylcellulose sodium, polysorbate 80, glycerin and ethyl-para-hydroxybenzoate. In the invention, a brand new medicament formula is adopted completely, two high molecular film forming materials, i.e., the polyvinyl alcohol and the carboxymethylcellulose sodium are used, the using amount ratio of the two film forming materials in a prescription is adjusted, so that the film forming property, flexibility and de-filming property of a medicinal film are improved; and the glycerin serving as a medicinal plasticizer is added, so that the flexibility of the medicinal film is improved. In the prescription, the polysorbate 80 is taken as a surfactant, so that uniform distribution of various medicaments and auxiliary material components in rubber paste is facilitated, and the film agent has a better clinical effect. Moreover, the invention further discloses a method for preparing the novel anti-inflammation and anti-allergy canker sore treating film agent. A product prepared with the method has high film forming property, high film coating property, high de-filming property and high flexibility, and the prepared medicinal film is uniform and is accordant with specifications.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for treating oral diseases, in particular to an anti-inflammatory, anti-allergy medicine for treating oral ulcers and a preparation method thereof. Background technique [0002] Oral ulcer is a common oral mucosal disease, also known as aphthous ulcer. The pain is very obvious during the outbreak, and it can heal without treatment. What also have shows effect repeatedly, is called recurrent oral ulceration, has caused very big impact to patient's work and life. At present, there are many kinds of medicines for the treatment of oral ulcers, including western medicine and traditional Chinese medicine. Western medicine mainly includes steroid hormones, various antibiotics, vitamins and other medicines, but due to factors such as curative effect and side effects, the selection and use of patients are affected. Traditional Chinese medicine mainly includes powders such as Bingboran Powder and Xilei Powd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/436A61K47/38A61K47/32A61K47/26A61P1/02
Inventor 陈健李威
Owner 四川梓橦宫药业股份有限公司
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