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Novel production technology of human-simulative bioengineering hyaluronic acid stock solution

A technology of bioengineering and hyaluronic acid, which is applied in the field of production technology of new hyaluronic acid imitating human bioengineering, can solve the problems of no bactericidal effect, poor deep moisturizing effect, poor water evaporation performance, etc., and achieve good moisturizing effect, Easy promotion and good repeatability

Inactive Publication Date: 2017-07-28
广州沛妍医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Usually, high molecular weight HA (≥ 1,000kDa) can form a layer of biofilm on the surface of the skin to tighten the skin and reduce the evaporation of water in the dermis and epidermis. However, due to its large molecular weight, it is difficult to penetrate the epidermis. Therefore, deep The moisturizing effect is poor; low molecular weight HA (1kDa ~ 1,000kDa) can penetrate into the epidermis, increase skin elasticity, nourish the skin, and delay skin aging. Does not have bactericidal effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A novel bioengineering hyaluronic acid production process imitating the human body, the production process specifically comprising the following steps:

[0029] Step 1: Raw material preparation, weighing 3 parts of sodium hyaluronate, 5 parts of hydrolyzed sodium hyaluronate, 4 parts of hydroxyethyl cellulose, 1 part of butanediol mixture, 1 part of hydrolyzed collagen mixture, 1 part of Angelica dahurica, 2 parts of Baizhu, 2 parts of forsythia, 1 part of honeysuckle, 2 parts of red peony root, 1 part of Sophora flavescens, 2 parts of licorice, 8 parts of inorganic alkali, 10 parts of ethanol, 80 parts of purified water;

[0030] Step 2: Preparation of traditional Chinese medicine extracts: using Radix Radix Angelicae, Angelica dahurica, Atractylodes macrocephala, forsythia, honeysuckle, red peony root, flavescens, and licorice to prepare traditional Chinese medicine extracts for use;

[0031] Step 3, dissolving sodium hyaluronate and hydrolyzed sodium hyaluronate in w...

Embodiment 2

[0044] A novel bioengineering hyaluronic acid production process imitating the human body, the production process specifically comprising the following steps:

[0045] Step 1: raw material preparation, weighing 5 parts of sodium hyaluronate, 8 parts of hydrolyzed sodium hyaluronate, 7 parts of hydroxyethyl cellulose, 2 parts of butanediol mixture, 2 parts of hydrolyzed collagen , 3 parts of Angelica dahurica, 3 parts of Atractylodes macrocephala, 5 parts of forsythia, 3 parts of honeysuckle, 5 parts of red peony root, 3 parts of Sophora flavescens, 4 parts of licorice, 10 parts of inorganic alkali, 15 parts of ethanol, 100 parts of purified water;

[0046] Step 2: Preparation of traditional Chinese medicine extracts: using Radix Radix Angelicae, Angelica dahurica, Atractylodes macrocephala, forsythia, honeysuckle, red peony root, flavescens, and licorice to prepare traditional Chinese medicine extracts for use;

[0047] Step 3, dissolving sodium hyaluronate and hydrolyzed sodi...

Embodiment 3

[0059] Embodiment 3: A kind of novel human body bioengineering hyaluronic acid stoste production process, described production process specifically comprises the following steps:

[0060] Step 1: Raw material preparation, weighing 4 parts of sodium hyaluronate, 6 parts of hydrolyzed sodium hyaluronate, 5 parts of hydroxyethyl cellulose, 1 part of butanediol mixture, 2 parts of hydrolyzed collagen , 2 parts of Angelica dahurica, 2 parts of Atractylodes macrocephala, 3 parts of forsythia, 2 parts of honeysuckle, 3 parts of red peony root, 2 parts of Sophora flavescens, 3 parts of licorice, 9 parts of inorganic alkali, 13 parts of ethanol, 90 parts of purified water;

[0061] Step 2: Preparation of traditional Chinese medicine extracts: using Radix Radix Angelicae, Angelica dahurica, Atractylodes macrocephala, forsythia, honeysuckle, red peony root, flavescens, and licorice to prepare traditional Chinese medicine extracts for use;

[0062] Step 3, dissolving sodium hyaluronate an...

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Abstract

The invention discloses a new production process of hyaluronic acid stock solution imitating human body bioengineering, which relates to the field of hyaluronic acid production, including five steps of preparation of raw materials and preparation of Chinese medicine extracts. The technical scheme of the invention is adopted, and the preparation steps are reasonable. It is easy to operate, does not add any harmful substances in the production process, and the prepared hyaluronic acid stock solution has a good moisturizing effect and has a bactericidal effect.

Description

technical field [0001] The invention relates to the field of hyaluronic acid production, in particular to a novel production process of imitating human bioengineering hyaluronic acid stock solution. Background technique [0002] Hyaluronic acid is a multifunctional matrix and one of the main components of the epidermis and dermis of human skin. Hyaluronic acid has high viscosity, plasticity, permeability, unique rheological properties and good biocompatibility, so the water transport in such tissues is slow, thus playing the role of regulating water distribution. This makes hyaluronic acid have a regulating effect on proteins and metabolites in the intercellular space, and also play a significant role as a lubricant. Studies have shown that hyaluronic acid plays a key role in regulating the migration behavior of various cellular components during embryogenesis. At the same time, it plays an important role in the tissue repair process, especially in the wound healing proces...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/73A61K8/65A61K8/34A61Q17/00A61Q19/00A61K36/87A61P31/00
CPCA61K8/97A61K8/345A61K8/65A61K8/731A61K8/735A61K36/232A61K36/284A61K36/355A61K36/484A61K36/489A61K36/634A61K36/65A61K36/71A61K36/87A61K2800/56A61Q17/005A61Q19/00
Inventor 卢宇鸿陈锡武南孟林
Owner 广州沛妍医疗科技有限公司
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