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Device and method for transporting magnetic or magnetisable beads

一种磁珠、磁场的技术，应用在DNA测序设备领域，能够解决运输困难、有效相对磁化率弱、颗粒磁量小等问题，达到完全灵活性、驱动方案和驱动电子设备简单的效果

Inactive Publication Date: 2012-05-30
KONINK PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the manipulation of these beads in general and their transport in particular is a difficult task, since the effective relative susceptibility of (super)paramagnetic beads is rather weak (typically <<1, due to the demagnetization effect) and the magnetic volume of the particles is small

Method used

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  • Device and method for transporting magnetic or magnetisable beads
  • Device and method for transporting magnetic or magnetisable beads
  • Device and method for transporting magnetic or magnetisable beads

Examples

Experimental program
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Embodiment Construction

[0051] It is well known that a single current wire creates a magnetic field that attracts a superparamagnetic bead towards the wire. Therefore if Figure 1A As depicted in , it is possible to transport the magnetic beads 10 on the transport surface 12 of the transport element 14 using a plurality of integrated current wires 16 a , 16 b , 16 c , 16 d deposited on the substrate 17 . By sequentially addressing the current wires 16a, 16b, 16c, 16d, a local magnetic field B is created l , so that the beads 10 are attracted to the corresponding current wires 16a, 16b, 16c, 16d. They thus move from left to right on the transport surface 12 . Such as Figure 1A As depicted in , the wires 16a, 16b, 16c, 16d may be covered by an isolation membrane acting as the transport element 14, the top of which is the transport surface 12.

[0052] In addition to the local magnetic field B generated by the current wires 16a, 16b, 16c, 16d l Besides, it can be applied by using an external sourc...

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Abstract

The present invention relates to a device (24) for transporting magnetic or magnetisable beads (10) over a transport surface (12). It comprises a chamber (26) comprising magnetic or magnetisable beads (10) in a fluid (28), a transport element (14) including said transport surface (12) within said chamber (26) over which said beads (10) shall be transported, a current wire structure (20) comprising at least two sets (20a, 20b, 20c) of meandering current wires arranged on a side of said transport element (14) opposite to said transport surface (12), said at least two sets (20a, 20b, 20c) being displaced with respect to each other in at least two directions, and a switching unit (32) for individually switching currents (1a, 1b, 1c) individually applied to said sets of current wires according to a current driving scheme resulting in a transport of said beads (10),over said transport surface (12). In preferred embodiments a stationary substantially uniform magnetic field (30) in a direction substantially parallel to the transport surface (12) is additionally provided.

Description

technical field [0001] The invention relates to a device and a corresponding method for transporting magnetic or magnetisable beads on a transport surface. [0002] Further, the present invention relates to a microfluidic device, in particular a DNA sequencing device, for manipulating a sample comprising magnetic or magnetisable beads, in particular for sequencing or nucleic acid testing. Background technique [0003] It is known that magnetic particles (“beads”) embedded in liquids can be used to carry on their surfaces probe molecules that specifically interact with complementary target molecules (e.g. single-stranded probes that interact with complementary target DNA DNA). From the reaction with the molecule to be probed and for example using optical or electrochemical measurements, the amount of the target molecule on the bead or within a volume containing the bead can be determined. The interest in using magnetic beads is that they can be manipulated using magnetic fi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01F13/00G01N35/00
CPCB03C1/0335B01L2400/043B03C1/24B01L3/502761B01L2200/0668B03C1/034B03C2201/18B01L3/00G01N35/00B01F33/00
Inventor J.M.J.登图恩德P.J.范德扎格H.C.曹
Owner KONINK PHILIPS ELECTRONICS NV
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