Photoacoustic and fluorescence dual-mode integrated tomography imaging system and imaging method

A technology of tomographic imaging and dual-mode integration, which is applied in the directions of acoustic wave diagnosis, infrasonic wave diagnosis, ultrasonic/sonic wave/infrasonic wave diagnosis, etc., which can solve the problems of high system cost and low system flexibility, and reduce system volume and system complexity , to avoid the effect of image registration operations

Inactive Publication Date: 2012-06-20
XIDIAN UNIV
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Problems solved by technology

Due to the use of femtosecond pulsed lasers, the system cost is high; the imaging object is placed in a water tank, and the system flexibility is low

Method used

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  • Photoacoustic and fluorescence dual-mode integrated tomography imaging system and imaging method
  • Photoacoustic and fluorescence dual-mode integrated tomography imaging system and imaging method
  • Photoacoustic and fluorescence dual-mode integrated tomography imaging system and imaging method

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Embodiment Construction

[0047] Attached below figure 1 , to further describe the device system of the present invention.

[0048] The photoacoustic and fluorescent dual-mode integrated tomography system of the present invention includes a modulatable laser light source 1, a vibrating mirror 2, a sample turntable 3, a filter wheel 4, a gated ICCD camera 5, a photoacoustic detection and acquisition module 6, and a system control system. Module 7 , computer 8 , data bus 9 and control bus 10 . in:

[0049] The modulated laser light source 1 includes a modulated signal generator and an adjustable continuous wave laser. The modulated signal generator mainly includes a field programmable gate array chip, a direct digital synthesis chip and a data interface. Both the direct digital synthesis chip and the data interface are connected to the field programmable gate array chip; the data interface receives the trigger signal from the system control module 7 and transmits it to the field programmable gate array...

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Abstract

The invention discloses a photoacoustic and fluorescence dual-mode integrated tomography imaging system and a photoacoustic and fluorescence dual-mode integrated tomography imaging method. The system comprises a modulation laser light source (1), a vibrating mirror (2), a sample rotary table (3), a filtering wheel (4), a gating intensified charge-coupled device (ICCD) camera (5), a photoacoustic detection acquisition module (6), a system control module (7), a computer (8), a data bus (9) and a control bus (10), wherein the vibrating mirror, the sample rotary table, the filtering wheel and the gating ICCD camera are positioned on the same straight line with the direction of lasers; the ultrasound transduction array normal direction of the photoacoustic detection acquisition module is perpendicular to the straight line to form a crossed vertical detection mode. According to the imaging method, light absorption distribution formed by photoacoustic tomography imaging is used as prior information for the reestablishment of fluorescence tomography imaging, and the positions of fluorophores, fluorescent yield and fluorescence lifetime parameters are reestablished by an iterative method. By the photoacoustic and fluorescence dual-mode integrated tomography imaging system and the photoacoustic and fluorescence dual-mode integrated tomography imaging method, the imaging complexity can be reduced, the cost of hardware can be saved, and the flexibility of the system and the reestablishing accuracy of the fluorescence tomography imaging can be improved.

Description

technical field [0001] The invention belongs to the technical field of imaging systems, in particular to a photoacoustic and fluorescent dual-mode integrated tomographic imaging system, which can perform high-precision reconstruction of light absorption parameters, fluorescent light source positions, fluorescent yields, and fluorescent lifetimes in complex organisms. It provides an effective means for detecting abnormalities at the cellular and molecular levels during the disease process, exploring the occurrence, development and metastasis of tumors, monitoring the treatment process, and evaluating the efficacy of drugs. Background technique [0002] Photoacoustic tomography is a non-destructive medical imaging method developed in recent years. It combines the high contrast characteristics of pure optical imaging and the high penetration depth characteristics of pure ultrasound imaging to provide high-resolution and high-contrast tissue imaging. Photoacoustic tomography is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B8/00
Inventor 陈多芳梁继民屈晓超朱守平陈雪利侯彦宾赵恒田捷
Owner XIDIAN UNIV
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