Medicinal composition for intestinal tract cleaning

An intestinal cleansing and composition technology, which is applied to the field of intestinal cleansing pharmaceutical compositions, can solve the problems of low yield, high L-glucose price, difficult separation of L-glucose, etc., and achieves convenient and quick administration and improved compliance. , the effect of reducing the cost of use

Active Publication Date: 2012-06-27
JINAN SHENGQUAN GROUP SHARE HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, the technical problem to be solved by the present invention is to overcome the problem that the L-glucose used for intestinal cleansing is difficult to be separated and

Method used

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  • Medicinal composition for intestinal tract cleaning
  • Medicinal composition for intestinal tract cleaning
  • Medicinal composition for intestinal tract cleaning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Add 2500ml of an aqueous solution containing 639.7g of sodium cyanide (pH 11.53) into the nitrogen replacement container for 10 minutes, then cool the solution to 7°C, slowly add concentrated acetic acid to adjust the pH to 7.94, and the temperature is 16°C. Then 1666g of 60wt% L-arabinose aqueous solution was added, concentrated acetic acid was added again to adjust the pH value to 8.1, and the reaction was carried out at 23°C. After cooling for 1.25h, 385ml of concentrated sulfuric acid was added to adjust the pH to 2.05. Product analysis showed that the conversion rate of L-arabinose was 99.4%.

[0026] The cyanide product was added to the nitrogen-protected hydrogenation tank, and 500 g of 5 wt % palladium barium sulfate catalyst was added. Sulfuric acid was added to control the pH value of the hydrogenation reaction at 2.0. After the reaction does not absorb hydrogen, the catalyst is removed by filtration, and the dissolved salt is removed by ion exchange to obta...

Embodiment 2～ Embodiment 11

[0031] Prepare the mixture of L-glucose and L-mannose in the following ratio (see Table 2), and the intestinal cleansing effect obtained is shown in Table 3:

[0032] The ratio of the pharmaceutical composition in Table 2 Embodiment 2~Example 11

[0033]

[0034] For the oral preparation for intestinal cleansing described in Example 2, the proportion of the pharmaceutical composition is 68wt%; the proportion of water is 32wt%, and the proportion of L-glucose in the pharmaceutical composition is 21.4wt%; L-mannose Accounting for the proportion of the pharmaceutical composition is 78.6wt%. Similarly, see Table 2 for the proportions of each component in Example 3 to Example 11.

[0035] Table 3 Comparison of intestinal cleansing effects of groups A and B in Example 2 to Example 11

[0036]

[0037] The above results show that the combination of L-glucose and L-mannose has a good colon cleansing effect, which is better than polyethylene glycol electrolyte powder (Heshuang)...

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Abstract

The invention discloses a medicine for colonoscopy and intestine tract preparation before colonic and rectal surgeries. The medicine is a medicinal combination containing L-glucose and L-mannose. The L-glucose and the L-mannose are not required to be separated, so the production cost is reduced; and the method has high industrial value. The medicinal combination of the L-glucose and the L-mannose has the characteristics of safety, reliability, convenience for use, good patient compliance and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition for intestinal cleaning, in particular to a pharmaceutical composition containing L-glucose and L-mannose. Background technique [0002] Bowel cleansing is required for colonoscopy, colon surgery, and bowel preparation before rectal surgery. Intestinal cleanliness is closely related to nosocomial infection control, clinical care quality, and the occurrence of complications. The cleanliness of intestinal preparation even directly affects the operation, inspection results, and various treatments. [0003] Bowel preparation methods include restricted diet, enema, and oral medication. Diet control alone cannot achieve the purpose of intestinal preparation, but is only a basic auxiliary method commonly used in various examinations and operations. Regular 1-2 days of light and low-fat diet with less dregs, liquid diet the night before, and fasting in the morning of the same day. The enema method is cum...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61P1/00
Inventor 唐一林郗遵波高绍丰
Owner JINAN SHENGQUAN GROUP SHARE HLDG
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