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Piracetam cerebroprotein hydrolysate dropping pill and preparation method thereof

A technology of cerebroprotein hydrolysate and piracetam, applied in the field of medicine, can solve the problems of low bioavailability of preparations, waste of resources and the like

Inactive Publication Date: 2012-07-04
张睿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Preparations using cerebroprotein hydrolyzate and piracetam as raw materials have been clinically used for many years, and the curative effect is remarkable. Currently, the preparations used clinically are tablets; however, there are many defects in the above-mentioned preparations in clinical application: the bioavailability of the preparation is not high , resulting in a waste of resources. Therefore, in order to meet the clinical needs, it is imperative to carry out in-depth development of preparations made of cerebroprotein hydrolyzate

Method used

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  • Piracetam cerebroprotein hydrolysate dropping pill and preparation method thereof
  • Piracetam cerebroprotein hydrolysate dropping pill and preparation method thereof
  • Piracetam cerebroprotein hydrolysate dropping pill and preparation method thereof

Examples

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Effect test

Embodiment 1

[0028] Prescription for dripping pills: the raw materials are piracetam 200g, brain protein hydrolysate 120g, glutamic acid 20g, chondroitin sulfate 20g, vitamin B 1 0.5g, vitamin B 2 0.5g, vitamin B 6 0.25g, 2g vitamin E, 726.5g matrix PEG1000;

[0029] (1) Preparation method of brain protein hydrolysate

[0030] Add the pig brain tissue to water, mash it, keep it at 65°C for 45 minutes, cool to 30°C, add oxalic acid solution to adjust the pH to 2.0, add pepsin 1.5% by weight of pig brain, stir and keep at 50°C for 6 hours, Collect the supernatant, precipitate and centrifuge, combine the supernatants, concentrate the supernatants under reduced pressure to 1 / 5 of the weight of the pig brain, adjust the pH to 5.0 with potassium hydroxide solution, inactivate at 100°C for 3 hours, and add water to the pig brain Weight, adjust pH to 6.5 with calcium hydroxide solution, filter, activated carbon adsorption, decarburization, and obtain clear liquid; add 1% trypsin by weight of clear l...

Embodiment 2

[0035] The formulation prescription is: the raw materials of the drug are 200g piracetam, 120g brain protein hydrolysate, 20g glutamic acid, 20g chondroitin sulfate, and vitamin B 1 0.5g, vitamin B 2 0.5g, vitamin B 6 0.25g, 2g vitamin E, 1453g matrix PEG1500;

[0036] (1) Preparation method of brain protein hydrolysate

[0037] Add the pig brain tissue to water, mash it, keep it at 90°C for 15 minutes, cool it to 50°C, add oxalic acid solution to adjust the pH to 4.0, add pig brain weight 4.5% pepsin, stir and keep at 50°C for 2 hours, Collect the supernatant, precipitate and centrifuge, combine the supernatants, concentrate the supernatant under reduced pressure to 1 / 2 of the weight of the pig brain, adjust the pH to 8.0 with sodium hydroxide solution, inactivate at 120°C for 3 hours, add water to the weight of the pig brain , Adjust the pH to 7.5 with calcium hydroxide solution, filter, adsorb on activated carbon, and decarbonize to obtain a clear liquid; add 3% trypsin by we...

Embodiment 3

[0042] The formulation prescription is: the raw materials of the drug are 200g piracetam, 120g brain protein hydrolysate, 20g glutamic acid, 20g chondroitin sulfate, and vitamin B 1 0.5g, vitamin B 2 0.5g, vitamin B 6 0.25g, vitamin E 2g, matrix PEG6000 3632.5g;

[0043] (1) Preparation method of brain protein hydrolysate

[0044] Add the pig brain tissue to water, mash it, keep it at 70°C for 20 minutes, cool it to 35°C, add oxalic acid solution to adjust the pH to 2.5, add pig brain weight 2.0% pepsin, stir and keep at 35°C for 3 hours, Collect the supernatant, precipitate and centrifuge, combine the supernatants, concentrate the supernatants under reduced pressure to 1 / 3 of the pig brain weight, adjust the pH to 6.0 with sodium bicarbonate solution, inactivate at 105°C for 5.5 hours, add water to the pig brain weight , Adjust the pH to 7.0 with calcium hydroxide solution, filter, adsorb on activated carbon, and decarbonize to obtain a clear liquid; add 2% trypsin by weight of...

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Abstract

The invention belongs to the technical field of medicines and discloses a piracetam cerebroprotein hydrolysate dropping pill and a preparation method thereof. The dropping pill comprises active ingredients and a substrate, wherein the active ingredients are composed of piracetam, cerebroprotein hydrolysate, and the like. The prescription of the dropping pill provided by the invention is confirmed according to a scientific screening test. A pharmacologic test proves that the dropping pill provided by the invention has better pharmacologic effect than that of the marketed preparation taking compound piracetam and cerebroprotein hydrolysate as raw materials.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a piracetam cerebroprotein hydrolysate dripping pill and a preparation method thereof. Background technique [0002] Piracetam is a drug called the central nervous system. Piracetam is a cyclized derivative of γ-aminobutyric acid with the molecular formula C 6 H 10 N 2 O 2 , The molecular weight is 142.2kDa. Piracetam has the effect of resisting brain damage caused by physical and chemical factors. It can promote ATP in the brain, promote the synthesis of acetylcholine and enhance the conduction of nerve excitement, and has the effect of promoting metabolism in the brain. It can combat brain damage caused by physical and chemical factors. It can improve retrograde amnesia caused by hypoxia. Can enhance memory and improve learning ability. Suitable for acute and chronic cerebrovascular disease, brain trauma, various toxic encephalopathy and other causes of memory loss and mild to...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K47/34A61K47/12A61K9/20A61P25/28A61K31/4015
Inventor 张睿
Owner 张睿
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