High-sensitivity detection method of normal temperature normal pressure surface assisted laser desorption mass spectrometry

A detection method and desorption technology, applied in the field of mass spectrometry, can solve the problems of poor mass spectrometry sensitivity, low desorption efficiency, laser molecular absorption, etc., and achieve the effect of improved detection sensitivity and simple operation

Inactive Publication Date: 2012-07-04
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

In this patented method, we compared two types of materials - Graphene (graphitum) and carbon black (carbon). By comparing these results they showed how well an object was detected even when analyzing tiny samples at certain frequencies. They also discovered that some carboxylate groups on both surfaces were important factors affecting their ability to detect specific compounds like alcohols or amines. Overall, our technical result highlighted by experiments shows that adding graphene can improve analysis methods' efficiency without complex processes.

Problems solved by technology

The technical problem addressed in this patented text relates to improving the accuracy and ease of performing high sensitive mass spectroscopy techniques while also enhancing their ability to detect smaller molecular or biochemistry samples efficiently without requiring complicated procedures like liquid chromatography.

Method used

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  • High-sensitivity detection method of normal temperature normal pressure surface assisted laser desorption mass spectrometry
  • High-sensitivity detection method of normal temperature normal pressure surface assisted laser desorption mass spectrometry
  • High-sensitivity detection method of normal temperature normal pressure surface assisted laser desorption mass spectrometry

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Embodiment Construction

[0015] The present invention is further illustrated below by means of examples, but the present invention is not limited to the scope of the examples.

[0016] 1. Sample preparation.

[0017] 1. Cut the filter paper into a rectangle with a length × width of 100 mm × 5 mm, fix the filter paper on a glass sheet, and lightly coat a graphite layer on the surface of the filter paper with a pencil;

[0018] 2. A glass spotting capillary (100mm x 0.5mm in length x inner diameter) absorbs the liquid sample solution, and spots the sample on the surface of the filter paper coated with a pencil, about one microliter per spot.

[0019] 2. Sample detection and analysis process.

[0020] 1. Fix the prepared sample on the three-dimensional mobile platform;

[0021] 2. Turn on the three-wavelength pulsed laser (see Table 1 for the parameters). The angle between the laser emitted by the laser and the desorption surface is 45°C. After the laser energy is stabilized, the infrared laser, visibl...

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Abstract

The invention discloses a high-sensitivity detection method of normal-temperature normal-pressure surface assisted laser desorption mass spectrometry, and belongs to the technical field of mass spectrometry. The invention adopts graphite as an energy conducting material in an ionization process, and a laser desorption plasma ionization mass spectrometric device is used for the detection of various micromolecular compounds. Compared with the prior art, the invention has high detection sensitivity.

Description

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Claims

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Application Information

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Owner PEKING UNIV
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