Chinese medicinal effective part compound preparation for treating vital myocarditis and preparation method thereof

A technology for viral myocarditis and compound preparations, applied in the directions of antiviral agents, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of mechanism of action, unclear active ingredients or effective parts group, large clinical application dose and effect. Not ideal and other problems, to achieve the effect of reducing serum myocardial enzyme activity, convenient application and low cost

Inactive Publication Date: 2013-08-14
包巨太
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Although western medicine has interferon, tumor necrosis factor, etc. for the treatment of viral myocarditis, the effect is not satisfactory, often with different degrees of adverse reactions, and the price is expensive
Traditional Chinese medicine has certain advantages in the treatment of this disease. Chinese invention patent CN2003101016314 discloses "Anti-Coxsackie B viral myocarditis capsule and its preparation method", which has good effects in treating viral myocarditis, but the mechanism of action of the drug, active ingredients or The effective parts and groups are not clear, and the clinical application dose is relatively large

Method used

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  • Chinese medicinal effective part compound preparation for treating vital myocarditis and preparation method thereof
  • Chinese medicinal effective part compound preparation for treating vital myocarditis and preparation method thereof
  • Chinese medicinal effective part compound preparation for treating vital myocarditis and preparation method thereof

Examples

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preparation example Construction

[0017] In the examples, a method for preparing a compound preparation of effective parts of traditional Chinese medicine for the treatment of viral myocarditis, the preparation steps are as follows: ① Selection of raw materials, select Chinese medicine American ginseng, Schisandra, Ophiopogon japonicus, Astragalus, Danpi, Scutellariae, Wangbuliu It can be cleaned and crushed into coarse powder, which can pass through the No. 2 sieve, but the amount that can pass the No. 4 sieve is not more than 40%; ②Prepared by weight percentage, the weight percentage of each Chinese medicine component is as follows: American ginseng 30- 40%, schisandra 4-15%, Ophiopogon japonicus 5-20%, astragalus 30-40%, paeonol 10-25%, scutellariae 5-15%, Wangbuliuxing 4-10%; ③To extract total flavonoids, Reference attached figure 1 , In the API, add 8 times the mass of the API and soak in 80% ethanol for 0.5h, then reflux for 2h, filter with 6 layers of gauze, and reflux the dregs with 6 times the mass of t...

Embodiment 1

[0019] Example 1: The percentages of total flavonoids, total saponins and total polysaccharides are 10%, 40% and 50% respectively. Example 2: The percentages of total flavonoids, total saponins and total polysaccharides are 15%, 30% and 55% respectively. Example 3: The percentages of total flavonoids, total saponins and total polysaccharides are 20%, 20% and 60% respectively.

[0020] The compound preparation of each example is a capsule, and the preparation process is as follows: the three components of total flavonoids, total saponins and total polysaccharides are compatible in the above proportions, dextrin is added as excipient, capsules are selected according to the needs of treatment, and No. 1 capsules are used for subpacking . According to clinical treatment experience, the daily dosage of the original prescription capsule is 18 capsules, and the daily dosage of the refined capsule is 6 capsules, which is 1 / 3 of the original preparation. Use the above examples to verify...

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Abstract

The invention relates to a Chinese medicinal effective part compound preparation for treating vital myocarditis and a preparation method thereof, and belongs to the technical field of Chinese medicinal compound preparations. In the technical scheme, 10 to 20 mass percent of extracted total flavones, 20 to 40 percent of extracted total saponins and 40 to 70 percent of extracted total polysaccharides are subjected to compatibility to prepare a compound preparation, wherein the total flavones, the total saponins and the total polysaccharides are powdery. The Chinese medicinal effective part compound preparation is applied to mice with vital myocarditis and myocardial cells infected by viruses to observe an antiviral effect and a myocardium protective effect of the compound preparation; and results indicate that the compound preparation can reduce the death rate of the mice with vital myocarditis, prolong survival time and reduce the activity of blood serum myocardial enzymes, has a protective effect on the myocardial cells and displays a good effect; and by toxicity experiments, toxic reaction is not discovered. The Chinese medicinal effective part compound preparation has the characteristics of high curative effect, small administration dose, convenience for application and the like.

Description

technical field [0001] The invention relates to a compound preparation of effective parts of traditional Chinese medicine for treating viral myocarditis and a preparation method thereof, in particular to a compound preparation of effective parts (ingredients) of Chinese medicine for treating Coxsackie B viral myocarditis and a preparation method thereof, belonging to the technology of compound preparations of traditional Chinese medicine field. Background technique [0002] Viral myocarditis is one of the common diseases in cardiovascular diseases, and it is also one of the refractory diseases. So far, there is no specific drug for treatment. Though western medicine has interferon, tumor necrosis factor etc. to be used for the treatment of viral myocarditis, the effect is all unsatisfactory, often has adverse reactions in various degrees, and the price is expensive. Traditional Chinese medicine has certain advantages in the treatment of this disease. Chinese invention paten...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P31/14A61P31/12
Inventor 包巨太韩淑英吴范武吕立勋马会霞郑彩慧储金秀李洁
Owner 包巨太
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