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Imaging method of samples for biological or chemical analysis

A flow cell, containment space technology used in the field of imaging samples for biological or chemical analysis that addresses the possible limited capabilities of the system and is not cost-effective

Active Publication Date: 2015-11-25
ILLUMINA INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, systems configured to carry out these scenarios may have limited capabilities and may not be cost-effective

Method used

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  • Imaging method of samples for biological or chemical analysis
  • Imaging method of samples for biological or chemical analysis
  • Imaging method of samples for biological or chemical analysis

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Embodiment Construction

[0083] Embodiments described herein include various systems, methods, assemblies, and devices for detecting desired reactions in samples for biological or chemical analysis. In some embodiments, the desired reaction provides an optical signal that is detected by an optical component. The optical signal may be light emission from a marker or may be transmitted light reflected or refracted by the sample. For example, embodiments may be used to perform or facilitate the performance of sequencing protocols in which sstDNA is sequenced in a flow cell. In specific embodiments, the embodiments described herein can also implement amplification protocols to generate relevant samples for sequencing.

[0084] As used herein, a "desired response" includes a change in at least one of the chemical, electrical, physical and optical properties or qualities of a substance in response to a stimulus. For example, the desired reaction may be a chemical transformation, chemical change, or chemic...

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Abstract

A method of performing a biological or chemical assay, the method comprising: (a) providing a fluidic device having a sample region and a reaction component storage unit having a plurality of different reaction components for performing one or more assays, the The reaction components include sample generation components and sample analysis components; (b) flow the sample generation components in according to a predetermined scheme to generate samples in the sample area; (c) selectively control the reaction conditions in the sample area to facilitate generating said sample; (d) flowing a sample analyte into said sample region; (e) detecting an optical signal emanating from said sample region indicative of a correlation between said sample analyte and said sample Event; where (b)-(e) are performed in an automated manner.

Description

technical field [0001] Embodiments of the invention generally relate to biological or chemical analysis methods and detection devices. Background of the invention [0002] Various assay protocols for biological or chemical research involve performing a large number of controlled reactions. In some cases, the controlled reaction is performed on a support surface. The desired reaction can then be observed and analyzed to help determine the properties or characteristics of the chemicals involved in the desired reaction. For example, in some protocols, a chemical moiety comprising an identifiable label (eg, a fluorescent label) can be selectively conjugated to another chemical moiety under controlled conditions. These chemical reactions can be observed by exciting the label with radiation and detecting light emission from the label. The light emission may also be provided by other means such as chemiluminescence. [0003] Examples of such protocols include DNA sequencing. I...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/01G02B7/00
Inventor 马克·王詹森·布赖恩特斯坦利·S·洪马克·普拉特戴尔·比尔曼亚历山大·P·欣德瓦尔詹森·哈里斯弗雷德里克·伊利安德鲁·詹姆斯·卡森马克·T·里德埃里克·威廉森布赖恩·克雷恩帕特里克·梁德鲁·韦卡德
Owner ILLUMINA INC