Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for treating retinal conditions using an intraocular tamponade

A therapeutic agent and biological technology, applied in sensory diseases, pharmaceutical formulations, drug combinations, etc.

Active Publication Date: 2012-08-08
ARCADOPHTA
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this procedure requires a second surgery at the end of the treatment to retrieve the bag

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for treating retinal conditions using an intraocular tamponade
  • Method for treating retinal conditions using an intraocular tamponade
  • Method for treating retinal conditions using an intraocular tamponade

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Composition of the present invention:

[0082]

[0083]

Embodiment 2

[0084] Embodiment 2: The physical and chemical property comparison of MCT and commonly used stuffing

[0085]

[0086] Table 1: Physical and Chemical Properties

Embodiment 3

[0087] Example 3: Evaluation of the non-emulsifying properties of compositions of the invention

[0088] In vitro evaluation

[0089] It is believed that any composition which passes the following test does not emulsify when or after intravitreal injection. 2 ml of any one of compositions 1-8 and 2 ml of water were placed in a vial. The vials were placed in a vortex mixer (model TOP-MIX from Fisher Scientific) at 500 rpm to mimic the movement of the head. Visually check to see if the composition is dispersed into fine oil droplets.

[0090] Results: Compositions 1-9 did not emulsify and each composition maintained a specific oil volume (foam).

[0091] In vivo evaluation

[0092] In vivo evaluations were performed to confirm the effects of the in vitro tests described above. The results of the in vivo evaluation confirm that the in vitro test is sufficient to evaluate whether a composition may or may not emulsify in vivo when or after intravitreal injection.

[0093] Pro...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Surface tensionaaaaaaaaaa
Dynamic viscosityaaaaaaaaaa
Dynamic viscosityaaaaaaaaaa
Login to View More

Abstract

Composition comprising at least one fatty acid glycerol ester for use during or after a vitrectomy procedure, said composition being bioresorbable, being injectable in the vitreous cavity, having a density below 1, more preferably comprised between 0.90 and 1, or a density above 1 more preferably between 1 and 1.5; having a surface tension of less than 50 dynes / cm more preferably ranging from 20 and 30 dynes / cm, being not susceptible to emulsify into droplets when injected; method for treating a retinal disorder involving the use of said composition.

Description

technical field [0001] The present invention relates to methods of treating ocular disorders, and ophthalmic compositions, particularly ophthalmic compositions for use in the vitreous cavity of the eye. [0002] More particularly, the present invention relates to a solution, and a method of using the solution to treat retinal detachment. Background technique [0003] The retina is the light-sensing layer of tissue located inside the eye, which transmits visual information to the brain via the optic nerve. The center of the retina is known as the macula and is the only part capable of distinguishing fine detailed vision. [0004] Due to reasons such as cataract surgery, posterior vitreous detachment, diabetic proliferative retinopathy, or trauma, the retina may separate from its underlying supporting tissue. When a retina detaches, the retina is lifted or pulled out of its normal position and away from its blood supply and source of nutrients. [0005] The initial detachme...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/00A61K47/14
CPCA61K47/14A61K9/0051A61K9/0048A61P27/02A61P41/00A61K9/08A61K9/0019A61K31/337A61K31/355A61K31/573
Inventor 让-塞巴斯蒂安·加里格弗里德里克·拉伦曼德杰弗里·海尔
Owner ARCADOPHTA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com