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Application of curcumin-zinc compound in preparing health-care nursing product

A technology of zinc compound and curcumin, which is applied in cosmetic preparations, skin care preparations, applications, etc., can solve the problems of single drug application and unsatisfactory curative effect, and achieve simple preparation methods, overcome single drug application, Apply promising effects

Active Publication Date: 2014-04-02
广东中大绿原生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide the application of curcumin-zinc compound in the preparation of antibacterial and analgesic drugs or health care products in view of the common problem of single drug application and unsatisfactory curative effect in the existing senile disease treatment

Method used

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  • Application of curcumin-zinc compound in preparing health-care nursing product
  • Application of curcumin-zinc compound in preparing health-care nursing product
  • Application of curcumin-zinc compound in preparing health-care nursing product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 curcumin-zinc compound

[0016] Curcumin, 99.6% pure, was provided by the Laboratory of Traditional Chinese Medicine and Marine Medicine, School of Life Sciences, Sun Yat-sen University. Zinc acetate dihydrate (abbreviation: zinc acetate), analytically pure, provided by Guangzhou Chemical Reagent Wholesale Department.

[0017] 4.8 grams of curcumin were dissolved in 300ml of absolute ethanol, 2.9 grams of zinc acetate were dissolved in 150ml of absolute ethanol, the zinc acetate ethanol solution was added dropwise in the curcumin ethanol solution, stirred while dropping, and heated under reflux for 3 hours, When the precipitation is complete, collect the precipitate by suction filtration, shake and suspend the precipitate with 300ml of 5°C absolute ethanol again, centrifuge at 5000rpm for 5min, collect the precipitate, then shake and suspend with 300ml of absolute ethanol, and centrifuge at 5000rpm for 5min to obtain 4.9 grams of curcumin...

Embodiment 2

[0018] Embodiment 2 The preparation of curcumin solid dispersion, curcumin-zinc compound solid dispersion

[0019] Curcumin, a curcumin-zinc compound with a purity of 99.6%, was provided by the Laboratory of Traditional Chinese Medicine and Marine Medicine, School of Life Sciences, Sun Yat-sen University. Polyvinylpyrrolidone PVP-k30 (referred to as PVP), imported and repackaged, provided by Guangzhou Chemical Reagent Wholesale Department.

[0020] 10.0 grams of curcumin were dissolved in 400ml of dehydrated ethanol solution containing 80.0 grams of PVP, protected by nitrogen gas, homogenized by a high-pressure homogenizer, and spray-dried to obtain 86.7 grams of curcumin-zinc solid dispersion.

[0021] 10.0 grams of curcumin-zinc compounds were dissolved in 400ml of dehydrated ethanol solution containing 80.0 grams of PVP, protected by nitrogen, homogenized by a high-pressure homogenizer, and spray-dried to obtain 86.2 grams of curcumin-zinc solid dispersion.

Embodiment 3

[0022] Example 3 Inhibition to various infectious bacteria

[0023] 1. Experimental samples

[0024] Escherichia coli M421C1 ST, catarrhalis, Shigella, Pseudomonas aeruginosa, Bacillus diphtheriae 38009, Diplococcus pneumoniae 31108, Streptococcus A 32213, Streptococcus B 32204, Staphylococcus aureus 26112, provided by the School of Basic Medicine, Sun Yat-sen University Microbiological laboratory identified and provided. Amoxicillin Capsules, Zhongshan Branch of Zhuhai United Laboratories Co., Ltd., Approval Number: Guoyao Zhunzi H20003263; Gentamicin Sulfate Injection, Tianjin Pharmaceutical Jiaozuo Co., Ltd., Approval Number: Guoyao Zhunzi H41020609; For Injection Ampicillin sodium, North China Pharmaceutical Co., Ltd., approval number: Guoyao Zhunzi H13020652; curcumin-zinc solid dispersion (curcumin-zinc: PVP, mass ratio is 1:8), curcumin solid dispersion (curcumin : PVP, the mass ratio is 1:8), the preparation method is the same as in Example 2, provided by the Laborat...

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Abstract

The invention discloses an application of curcumin-zinc compound in preparing a health-care nursing product. According to the application of the curcumin-zinc compound in preparing the health-care nursing product, the curcumin-zinc compound is found to have good bacteriostasis and analgesia action and can be used for treating common diseases, such as retinopathy, skin ulcer and the like caused by bacterial infection, pain and diabetic complications, has an obvious curative effect on treating various senile diseases and has wide application. The curcumin-zinc compound can be used for preparing medicines and also can be used for preparing various health-care products. According to the curcumin-zinc compound, the problems of single medicine adaptive symptom and poor curative effect commonly existing in the traditional senile disease treatment are overcome. The curcumin-zinc compound has the advantages of simple preparation method and wide application prospect.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to the medical and health care applications of curcumin-zinc compounds in antibacterial and analgesic aspects. Background technique [0002] Total curcumin [including curcumin, demethoxycurcumin, bisdemethoxycurcumin], the main active ingredient is curcumin, which has a good free radical scavenging , anti-oxidation, anti-mutation, anti-aging, anti-radiation, anti-virus, anti-cancer, anti-cancer, lowering blood fat and cholesterol, anti-atherosclerosis, treatment of depression and other health care and pharmacological effects. [0003] Curcumin and copper ions can form metal complexes in ratios of 1:1 and 1:2. Cu(II)–curcumin metal complex has a stronger ability than curcumin to scavenge free radicals induced by γ-rays and cadmium and simulate SOD antioxidant capacity. Curcumin-magnesium complex, as a neuroprotective agent, has a better effect on scavenging free radicals ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/315A61P31/04A61P29/00A61K8/58A61Q11/00A61Q5/02A61Q19/00A23L1/30
Inventor 许实波梅宁毅
Owner 广东中大绿原生物科技有限公司
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