Application of curcumin-zinc compound in preparing bacteriostatic analgesics or health care products

A technology of zinc compound and curcumin, which is applied in application, food preparation, antibacterial drugs, etc., can solve the problems of unsatisfactory curative effect and single application of drugs, and achieve the single application of drugs, simple preparation method and promising application prospects broad effect

CN101904835BActive Publication Date: 2012-05-30广东中大绿原生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2012-05-30

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Abstract

The invention discloses application of a curcumin-zinc compound in preparing bacteriostatic analgesics. The invention discloses the curcumin-zinc compound has good bacteriostatic abirritation, can be used for curing common diseases of retinopathy, skin ulcer and the like caused by bacterial infection, pains and complications of diabetes and has effective treatment and wide application in curing various senile diseases. The curcumin-zinc compound can be used for preparing drugs and various health care products and solves the problems of single indication of the drugs and undesirable curative effect in curing the senile diseases at present. The curcumin-zinc compound has simple preparation method and wide application prospect.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical compositions, in particular to the medical and health care applications of curcumin-zinc compounds in antibacterial and analgesic aspects. Background technique

[0002] Total curcumin [including curcumin, demethoxycurcumin, bisdemethoxycurcumin], the main active ingredient is curcumin, which has a good free radical scavenging , anti-oxidation, anti-mutation, anti-aging, anti-radiation, anti-virus, anti-cancer, anti-cancer, lowering blood fat and cholesterol, anti-atherosclerosis, treatment of depression and other health care and pharmacological effects.

[0003] Curcumin and copper ions can form metal complexes in ratios of 1:1 and 1:2. Cu(II)-curcumin metal complex has a stronger ability than curcumin to scavenge free radicals induced by γ-rays and cadmium and simulate SOD antioxidant capacity. Curcumin-magnesium complex, as a neuroprotective agent, has a better effect on scavenging free radicals ...

Examples

Embodiment 1

[0014] The preparation of embodiment 1 curcumin-zinc compound

[0015] Curcumin, 99.6% pure, was provided by the Laboratory of Traditional Chinese Medicine and Marine Medicine, School of Life Sciences, Sun Yat-sen University. Zinc acetate dihydrate (abbreviation: zinc acetate), analytically pure, provided by Guangzhou Chemical Reagent Wholesale Department.

[0016] 4.8 grams of curcumin were dissolved in 300ml of absolute ethanol, 2.9 grams of zinc acetate were dissolved in 150ml of absolute ethanol, the zinc acetate ethanol solution was added dropwise in the curcumin ethanol solution, stirred while dropping, and heated under reflux for 3 hours, When the precipitation is complete, collect the precipitate by suction filtration, shake and suspend the precipitate with 300ml of 5°C absolute ethanol again, centrifuge at 5000rpm for 5min, collect the precipitate, then shake and suspend with 300ml of absolute ethanol, and centrifuge at 5000rpm for 5min to obtain 4.9 grams of curcumin...

Embodiment 2

[0017] The preparation of embodiment 2 curcumin solid dispersion, curcumin-zinc compound solid dispersion

[0018] Curcumin, a curcumin-zinc compound with a purity of 99.6%, was provided by the Laboratory of Traditional Chinese Medicine and Marine Medicine, School of Life Sciences, Sun Yat-sen University. Polyvinylpyrrolidone PVP-k30 (referred to as PVP), imported and repackaged, provided by Guangzhou Chemical Reagent Wholesale Department.

[0019] 10.0 grams of curcumin were dissolved in 400ml of dehydrated ethanol solution containing 80.0 grams of PVP, protected by nitrogen gas, homogenized by a high-pressure homogenizer, and spray-dried to obtain 86.7 grams of curcumin-zinc solid dispersion.

[0020] 10.0 grams of curcumin-zinc compounds were dissolved in 400ml of dehydrated ethanol solution containing 80.0 grams of PVP, protected by nitrogen, homogenized by a high-pressure homogenizer, and spray-dried to obtain 86.2 grams of curcumin-zinc solid dispersion.

Embodiment 3

[0021] Embodiment 3 is to the inhibitory action of multiple infectious bacteria

[0022] 1. Experimental samples

[0023] Escherichia coli M421C1 ST, catarrhalis, Shigella, Pseudomonas aeruginosa, Bacillus diphtheriae 38009, Diplococcus pneumoniae 31108, Streptococcus A 32213, Streptococcus B 32204, Staphylococcus aureus 26112, provided by the School of Basic Medicine, Sun Yat-sen University Microbiological laboratory identified and provided. Amoxicillin Capsules, Zhongshan Branch of Zhuhai United Laboratories Co., Ltd., Approval Number: Guoyao Zhunzi H20003263; Gentamicin Sulfate Injection, Tianjin Pharmaceutical Jiaozuo Co., Ltd., Approval Number: Guoyao Zhunzi H41020609; For Injection Ampicillin sodium, North China Pharmaceutical Co., Ltd., approval number: National Drug Accreditation H13020652; curcumin-zinc solid dispersion (curcumin-zinc: PVP, mass ratio is 1: 8), curcumin solid dispersion (curcumin : PVP, the mass ratio is 1: 8), the preparation method is the same as ...