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Compound antibiotic composition for preventing and curing piglet bacterial diarrhea and preparation method of particulate premix thereof

A bacterial and antibiotic technology, which is applied in the field of compound antibiotic composition and its granular premix preparation process, can solve the problems of piglet respiratory disease, reduced curative effect, drug pollution, etc., to reduce stress and operation of animals Convenience, weight gain promoting effect

Inactive Publication Date: 2012-09-12
北京中农大动物保健品技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Both amoxicillin and apramycin have strong effects on the two most important pathogenic bacteria (E. The emergence of drug resistance leads to reduced curative effect or even ineffective use, and there are currently no amoxicillin and apramycin compound preparations at home and abroad
In addition, the operation of conventional premix (powder premix) often causes drug waste and drug pollution due to flying dust, and can easily cause respiratory diseases in piglets

Method used

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  • Compound antibiotic composition for preventing and curing piglet bacterial diarrhea and preparation method of particulate premix thereof
  • Compound antibiotic composition for preventing and curing piglet bacterial diarrhea and preparation method of particulate premix thereof
  • Compound antibiotic composition for preventing and curing piglet bacterial diarrhea and preparation method of particulate premix thereof

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preparation example Construction

[0032] The present invention also provides a preparation method of the compound antibiotic composition granular premix for preventing and treating piglet bacterial diarrhea, comprising the following steps:

[0033] 1) Weigh amoxicillin, apramycin, disintegrant and carrier according to the above weight percentage, and prepare an aqueous binder solution with a concentration of 0.5-1.0% (g / 100mL);

[0034] 2) Add the disintegrating agent, apramycin, amoxicillin and the carrier to the mixer in sequence, and after mixing for 20-40 minutes, add the aqueous binder solution and mix well to make a soft material with moderate viscosity;

[0035] 3) Add the prepared soft material into an extrusion spheronizer, extrude and spheronize, dry, and sieve to make granules with a particle size of 30-60 mesh, which is a compound antibiotic composition for preventing and treating bacterial diarrhea in piglets Granular premix.

Embodiment 1-8

[0038] Example 1-8, preparation of compound antibiotic composition granular premix for preventing and treating piglet bacterial diarrhea

[0039] The formula of the compound antibiotic composition granular premix of embodiment 1-8 preventing and treating piglet bacterial diarrhea is as shown in table 1:

[0040] Example 1-8 The formula of compound antibiotic composition granular premix for preventing and treating piglet bacterial diarrhea

[0041]

[0042] The preparation method of the compound antibiotic composition granular premix of embodiment 1-8 preventing and treating piglet bacterial diarrhea comprises the following steps:

[0043] 1) Take amoxicillin, apramycin, disintegrant and carrier according to the above-mentioned formula quantity, and prepare an aqueous binder solution;

[0044] 2) Add the disintegrating agent, apramycin, amoxicillin and the carrier to the mixer in sequence, and after mixing for 20-40 minutes, add the formulated amount of sodium carboxymethyl...

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Abstract

The invention discloses a compound antibiotic composition for preventing and curing piglet bacterial diarrhea and a preparation technology of a particulate premix thereof. Active components of the composition are Amoxicillin and apramycin with effective curative dose, and the dosage form is a particulate premix. With the organic combination of Amoxicillin and apramycin, the antibiosis effect of a single agent is greatly utilized, synergetic antibacterial advantages of the combination of the two drugs are displayed, and the combination of the two drugs widens antimicrobial spectrum, enhances antibiosis effectiveness and alleviates the generation speed of bacterial resistance. The compound antibiotic composition is mainly used to prevent and cure piglet bacterial diarrhea in clinic and simultaneously can be used to prevent and cure mixed infection caused by animal gram-positive bacteria and gram negative bacteria. The preparation technology is simple and easy to realize industrialization, requires low cost, is safe and efficient, and has high popularization and application values.

Description

technical field [0001] The invention belongs to the field of feed drug additives, and in particular relates to a compound antibiotic composition for preventing and treating bacterial diarrhea in piglets and a preparation process for a granular premix thereof. Background technique [0002] At present, the incidence of bacterial diarrhea in piglets remains high and the effect of drug control is low, which brings great economic losses to pig production. The main reason is that various bacteria that cause diarrhea in piglets, such as Escherichia coli, Salmonella, Treponema hyodysenteriae, Clostridium welchii, etc., especially the most important pathogenic bacteria (Escherichia coli, Salmonella) that cause diarrhea in piglets, develop resistance Drug-induced. [0003] Amoxicillin is a semi-synthetic broad-spectrum penicillin drug, and its antibacterial spectrum includes Escherichia coli, Salmonella, Pasteurella, Actinobacillus, Haemophilus and other pathogenic bacteria; Includi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K31/43A61K9/16A61P31/04A61P1/12
Inventor 肖希龙汤树生赵婷婷陈琳琳
Owner 北京中农大动物保健品技术研究院
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