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Controllable micro infusion device based on osmotic pressure as power

An infusion device and technology of osmotic pressure, applied in infusion sets, syringes, medicine devices, etc., can solve the problems of limited amount of medicines and cannot meet the requirements of medicine infusion, etc., to achieve convenient medicine, avoid first-pass effect and overcome limitations Effect

Active Publication Date: 2014-07-30
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the microneedles are thin and sharp, the height is only about a few hundred microns, and the diameter is only tens of microns, so the amount of drug delivered is very limited, which cannot meet the needs of relatively large drug infusions.

Method used

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  • Controllable micro infusion device based on osmotic pressure as power
  • Controllable micro infusion device based on osmotic pressure as power
  • Controllable micro infusion device based on osmotic pressure as power

Examples

Experimental program
Comparison scheme
Effect test

no. 1 example ）

[0042] Figure 3a-Figure 3b A schematic view showing the infusion device according to the first embodiment of the present invention before and during use. Figure 3c and Figure 3d A side sectional view and a top view of the base are respectively shown. Figure 3e A side cutaway view of the reservoir is shown. Figure 3f and Figure 3g A side sectional view and a top view of the dosing unit support seat are respectively shown.

[0043] like Figure 3a and Figure 3b As shown, the container 2 includes a base 21 and a reservoir 22 .

[0044] like Figure 3c and Figure 3d As shown, the base 21 includes a circular bottom wall 210 and a cylindrical side wall 212, the top of the base is open, and the center of the bottom wall is formed with a weak portion 214 for needles to pass through. A piercing portion 216 protruding upward and having a fluid channel formed inside is formed on an annular area near the outer peripheral edge.

[0045] like Figure 3e As shown, the rese...

no. 2 example ）

[0050] Figure 4a-Figure 4b A schematic view of an infusion device according to a second embodiment of the present invention before and during use is shown. Figure 4c and Figure 4d A side sectional view and a top view of the base are respectively shown. Figure 4e and Figure 4f A side sectional view and a top view of the reservoir are shown, respectively.

[0051] like Figure 4a and 4b As shown, the container 2 includes a base 21 and a reservoir 22 .

[0052] like Figures 4a-4d As shown, the base 21 includes a circular bottom wall 210 and a cylindrical side wall 212, the top of the base is open, and the needle 3 (optionally via a needle seat) is fixed to the central part of the bottom wall, so A sealing boss 214 protruding upward is formed on an annular area near the outer peripheral edge of the bottom wall.

[0053] like Figure 4e and Figure 4f As shown, the reservoir 22 has an integral cylindrical outer wall 221, a cylindrical inner wall 223, an annular bott...

no. 3 example ）

[0056] Figure 5a-Figure 5b A schematic view of an infusion device according to a third embodiment of the present invention before and during use is shown. Figure 5c shows the pin header, Figure 5d The dosing unit is shown integral with the dosing unit support seat.

[0057] The difference between this embodiment and the second embodiment is that a slide bar 7 that passes through the top cover 227 of the liquid reservoir 22 is also provided; the dosing unit 4 is connected with a dosing unit support base 5, and is realized by means of the slide bar. Connection to header 35.

[0058] Specifically, the sliding rod 7 passes through the center of the circular top wall 227 of the liquid reservoir along the axial direction of the liquid reservoir, and is slidably engaged with the circular top wall; The side opposite to the drug delivery outlet is engageable with the lower end of the slide bar. One side of the dosing unit support seat 5 is fixed around the drug delivery outlet o...

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Abstract

The invention provides a controllable micro infusion device based on osmotic pressure as power. The controllable micro infusion device comprises a container, a needle and an administration unit, wherein the container is provided with a chamber for accommodating working fluid; the needle is fixed relative to the container or can be fixed, so that a fluid output end stretches from the container for a certain distance; and the administration unit with the osmotic pressure serving as the power is positioned in the container and comprises a medicine chamber defined by a semi-permeable membrane portion, the medicine chamber is used for accommodating medicine-containing contents including medicine and osmotic pressure active materials, the semi-permeable membrane portion allows the working fluid to pass so as to enter the medicine chamber but does not allow the medicine-containing contents to pass reversely and flow out, and a medicine outlet is formed on the semi-permeable membrane portion and operationally communicated with an fluid input end directly or indirectly. The working fluid is separated from the semi-permeable membrane portion before operation of the infusion deice, and the semi-permeable membrane portion contacts with the working fluid when the infusion device works, so that the medicine discharged from the medicine releasing device outlet enters a body of a patient through the fluid output end of the needle.

Description

technical field [0001] The invention relates to an infusion device, in particular to an infusion device powered by osmotic pressure, which is especially suitable for realizing self-injection administration in battlefields, clinics and other conditions where it is not convenient to establish intravenous access. Background technique [0002] Injection preparations have become one of the most important preparation forms of drugs due to their direct action and quick onset of action. In the innovation wave of the rapid development of traditional conventional preparations to the fourth-generation targeted preparations, the preparations have been adapted to ensure safety and effectiveness. The development trend of easy use and less toxic and side effects has gradually expanded to a variety of injection forms, mainly including conventional injections, pre-flushed injections, needle-free injections, and automatic emergency injection needles. These injection administration forms have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00A61M5/178
Inventor 梅兴国马瑞李志平
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A