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Yougui capsule and preparation method thereof

A technology for capsules and formulations, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as unfavorable gastrointestinal absorption, incomplete utilization, and large oral dosage, and achieves improved therapeutic effect, convenient administration, The effect of increasing the potency of the drug

Active Publication Date: 2012-10-03
JIANGXI YINTAO PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of Yougui Pill is simple, and many active ingredients of traditional Chinese medicine are not fully utilized, which is not conducive to the absorption of the stomach; the original traditional view believes that the ursolic acid in the formula Cornus officinalis is a fat-soluble component, which mainly plays an anti-inflammatory effect; The contribution of flavonoid glycosides to making up for kidney deficiency is not obvious. Therefore, in the Yougui capsule process described in the patent application number 200510019873.8, the ursolic acid in Cornus officinalis and the flavonoids of Cuscuta were not collected, but simply used It is decocted and extracted, so the medicinal effect is average; at the same time, the oral dosage is relatively large, and it is inconvenient to take
There are no reports in the existing literature that ursolic acid in Cornus officinalis and flavonoid glycosides in dodder contribute to the compensation of kidney deficiency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A Yougui capsule, the formula of which is: 290g rehmannia glutinosa, 72g aconite (paofupian), 73g cinnamon, 140g yam, 110g dogwood, 140g dodder, 145g antler gum, 145g medlar, 110g angelica, eucommia (stir-fried with salt) 145g; full formula as 1000 capsules.

[0019] Its preparation method is:

[0020] (1) Add 8.5L of ether to Cornus officinalis, reflux and extract at 50°C for 4h, recover the ether, volatilize to dryness, soak the residue twice in petroleum ether at 30-60°C for 2min each time, pour off the petroleum ether, and use 5 times the residue Weight of dehydrated ethanol is dissolved as solution A, and the extracted cornus medicinal residue is cornel medicinal residue B, which is for subsequent use;

[0021] (2) Crush the dodder, pass through a 40-mesh sieve, degrease with 8.0 L of petroleum ether at 60-90°C at 78°C for 3 hours, extract the dregs with 95% ethanol for 3 times, and concentrate the extract to a relative density of 1.65 at 65°C thick paste, as...

Embodiment 2

[0027] A Yougui capsule, its formula is: rehmannia glutinosa 300g, aconite (paofupian) 75g, cinnamon 75g, yam 150g, dogwood 112.5g, dodder 150g, antler gum 150g, medlar 150g, angelica 112.5g, eucommia (salt Fried) 150g; the whole formula is made into 1000 capsules.

[0028] Its preparation method is:

[0029] (1) Add 8.6L of ether to Cornus officinalis, reflux and extract at 55°C for 4h, recover the ether, volatilize to dryness, soak the residue twice in petroleum ether at 30-60°C for 2min each time, pour off the petroleum ether, and use 5 times the residue Weight of dehydrated ethanol is dissolved as solution A, and the extracted cornus medicinal residue is cornel medicinal residue B, which is for subsequent use;

[0030] (2) Crush the dodder, pass through a 40-mesh sieve, use 8.5 L of petroleum ether at 60-90°C to degrease at 83°C for 3 hours, extract the dregs with 95% ethanol for 3 times, and concentrate the extract to a relative density of 1.65 at 65°C. thick paste,...

Embodiment 3

[0035]A Yougui capsule, the formula of which is: 310g rehmannia glutinosa, 78g aconite (paofupian), 77g cinnamon, 160g yam, 115g dogwood, 160g dodder, 155g antler gum, 155g medlar, 115g angelica, Eucommia (stir-fried with salt) 155g; full formula made into 1000 capsules.

[0036] Its preparation method is:

[0037] (1) Add 8.7L of ether to Cornus officinalis, reflux and extract at 60°C for 4 hours, recover the ether, volatilize to dryness, soak the residue twice in petroleum ether at 30-60°C for 2 minutes each time, pour off the petroleum ether, and wash the residue with 5 times Weight of dehydrated ethanol is dissolved as solution A, and the extracted cornus medicinal residue is cornel medicinal residue B, which is for subsequent use;

[0038] (2) Crush the dodder, pass through a 40-mesh sieve, degrease with 9.0 L of petroleum ether at 60-90°C at 88°C for 3 hours, extract the dregs with 95% ethanol for 3 times, and concentrate the extract to a relative density of 1.65 at...

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Abstract

The invention discloses a Yougui capsule and a preparation method of the Yougui capsule. The Yougui capsule comprises the following raw materials: cooked rehmannia, giant typhonium rhizome, cassia bark, common yan rhizome, dogwood, south dodder seed, buckhom glue, fructus lycii, Chinese angelica root, and cortex eucommiae. According to the Yougui capsule and the preparation method of the Yougui capsule, a preparation process is improved on the basis of Yougui pills, the effective components of medicine in the formula are extracted effectively and the effect of treating kidney deficiency is improved; and the dosage form is changed, so that patients take the capsules easily and conveniently, and the patients' requirements on pharmaceutical effect and convenience of the medicine are satisfied. And most clinic applications prove that the Yougui capsule has remarkable curative effects on asynodia, spermatorrhea, chronic nephritis, nephropathy syndrome, osteoporosis, esteoproliferation, osteocomma aches, climacteric syndrome of women and sterility and the like.

Description

technical field [0001] The invention relates to a Yougui capsule and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Kidney deficiency refers to that kidney vital essence negative and positive are not enough. Kidney deficiency is mainly divided into kidney-yin deficiency and kidney-yang deficiency. There are many types of kidney deficiency referred to by traditional Chinese medicine, the most common of which are kidney-yin deficiency and kidney-yang deficiency. Symptoms of kidney deficiency: the symptoms of kidney yang deficiency are backache, cold limbs, chills, and even edema, that is to say, it is manifested as "cold" symptoms. Symptoms are "heat", mainly including backache, dry heat, night sweats, night sweats, dizziness, tinnitus, etc. [0003] At present, there are Yougui Pills and other medicines for the treatment of kidney deficiency. Yougui Pills are composed of rehmannia glutinosa, ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/48A61P1/14A61P13/12A61P15/08A61P15/10A61P15/12A61P19/08A61P19/10A61K35/32
Inventor 张建荣李后如
Owner JIANGXI YINTAO PHARMACEUTICAL CO LTD
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