Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of (3R)-des-O-methyl lasiodiplodin in preparation of drugs for preventing or treating depression

A technology for methyl-maodiposen and depression, which is applied in the field of medicine and can solve the problems such as research reports on the biological activity of such compounds that have not yet been found.

Inactive Publication Date: 2014-04-30
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching the literature, no research report on the biological activity of this type of compound has been found so far.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of (3R)-des-O-methyl lasiodiplodin in preparation of drugs for preventing or treating depression
  • Application of (3R)-des-O-methyl lasiodiplodin in preparation of drugs for preventing or treating depression
  • Application of (3R)-des-O-methyl lasiodiplodin in preparation of drugs for preventing or treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: The antidepressant effect of the benzomacrolide compound (3R)-des-O-methylmadiprene in the forced swimming model of mice.

[0014] [Experimental purpose] The mouse model of forced swimming was used to observe the antidepressant effect of benzomacrolide (3R)-des-O-methylmaudepredrine.

[0015] [Experimental animals] KM mice, 20-22g, both male and female.

[0016] [Sample treatment] Orally administer the compound to the mice by 0.1ml / 10g volume body weight, wherein, according to the following steps, a certain concentration of the compound solution is prepared with a dose of 40mg / kg: Weigh a certain amount of benzomacrolide compound ( 3R)-de-O-methylmaudeprene, dissolved with 4% (volume percent) DMSO (dimethyl sulfoxide), and aided with 5% (volume percent) Tween-20 (Tween-20) Dissolve, make it fully dissolved, and the rest is normal saline. In addition, other test concentrations of compounds were diluted with solvent control 2 (4% DMSO+5% Tween-20+91% saline, ...

Embodiment 2

[0020] Example 2: The antidepressant effect of the benzomacrolide compound (3R)-des-O-methylmadiprene in the mouse tail suspension behavior model.

[0021] [Experimental purpose] To observe the antidepressant effect of the test compound in the mouse tail suspension behavior model.

[0022] [Experimental animals] KM mice, 20-22g, both male and female

[0023] [Sample treatment] Orally administer the compound to the mice by 0.1ml / 10g volume body weight, wherein, according to the following steps, a certain concentration of the compound solution is prepared with a dose of 40mg / kg: Weigh a certain amount of benzomacrolide compound ( 3R)-Des-O-methylmadipredine was dissolved with 4% (volume percentage) DMSO, and 5% (volume percentage) Tween-20 was used to help dissolve it, so that it was fully dissolved, and the rest was normal saline. In addition, other test concentrations of compounds were diluted with solvent control 2 (4% DMSO+5% Tween-20+91% saline, volume ratio). The positiv...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of medical technologies and relates to an application of a compound (3R)-des-O-methyl lasiodiplodin in preparation of drugs for preventing or treating diseases such as depression and the like, wherein the compound is obtained by extraction and separation of Chinese mangrove plant cerbera manghas. (3R)-des-O-methyl lasiodiplodin provided by the invention has a structure as shown in the following chemical formula 1. It shows through in vivo detection that the compound has an obvious antidepressant effect. The invention also can provide a novel lead compound for preventing and treating depressant diseases and is of great significance for developing and utilizing Chinese marine biological resources. The chemical formula 1 is shown in the desctiption.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular, to a compound (3R)-des-O-methylmadiprolone [(3R )-des-O-methyllasiodiplodin] in the new application in pharmacy, especially relates to, the purposes in the medicine of preparation prevention or treatment depression. Background technique [0002] Depression includes unipolar depression, adjustment disorder, minor depression, seasonal affective disorder, postpartum depression, bipolar disorder, and manic depression. Statistics show that my country's antidepressant drug market is a rapidly growing market, with an average growth rate of more than 20% in the past five years. There are now more than 26 million people suffering from depression in our country, and the direct and indirect economic losses caused by it are about 8 billion U.S. dollars every year. Among the 340 million children and adolescents under the age of 17, about 30 million suffer from emotional and psycholog...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P25/24
Inventor 章海燕郭跃伟唐希灿龚景旭王维江成世
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI