Composition including naphthoquinone compound for treating and preventing hearing loss

A technology for hearing loss and composition, which is applied in the direction of drug combination, active ingredients of heterocyclic compounds, medical preparations containing active ingredients, etc., and can solve the problems of unapproved prevention and treatment of hearing loss

Inactive Publication Date: 2012-10-24
MAZENCE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, antioxidants, N-methyl-D-aspartic acid (NMDA) antagonists, apoptosis inhibitors, etc. have been reported, but there are still no approved drugs for the prevention and treatment of hearing loss

Method used

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  • Composition including naphthoquinone compound for treating and preventing hearing loss
  • Composition including naphthoquinone compound for treating and preventing hearing loss
  • Composition including naphthoquinone compound for treating and preventing hearing loss

Examples

Experimental program
Comparison scheme
Effect test

experiment Embodiment 1

[0088] Experimental Example 1: Animal Model of Age-Related Presbycusis

example 1-1

[0089] Laboratory Example 1-1: Preparation of Animal Models

[0090] C57BL / 6 mice known as a model of age-related hearing loss were used for this experiment. 12-month-old C57BL / 6 mice were purchased directly from the Animal Company Experiment Center (Central Lab. Animal Inc., Seoul, Korea), and raised to 24 months of age, while hearing loss was measured every 3 months. All mice used in this experiment were housed in a sterile (germfree) animal facility maintained at constant temperature (22–26°C) and humidity (55–60%).

[0091] All experiments were performed on all groups divided into a control group fed ad libitum with normal feed, a caloric restriction (CR) group restricted to 70% of the diet, and a βL group fed a feed containing 0.06% β-lapachone (Compound I). Group.

experiment Embodiment 1-2

[0092] Experimental Example 1-2: Changes in Auditory Brainstem Response (ABR) Threshold

[0093] To assess auditory brainstem responses, all experimental animals were injected intramuscularly with a mixture of xylazine (5 mg / kg) and ketamine for anesthesia, and the auditory brainstem was measured using a TDT system (Tucker-Davis Technologies, FL, USA) in a soundproof room. Changes in dry response threshold.

[0094] An insertable ear tip (3.5 mm, Nicolet Biomedical) was placed in the external auditory canal and electrodes were placed in the apex of the scalp (active electrode), mastoid region of the ear of interest (control electrode) and on the opposite ear. mastoid region (ground electrode), and the threshold of ABR was determined by an initial 90 dB HL intensity followed by a sequential 10 dB decrease at 4, 8, 16 and 32 kHz.

[0095] During the ABR test, no arousal response and death due to respiratory depression occurred. ABR thresholds between groups were compared by on...

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PUM

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Abstract

The present invention relates to a composition including a naphthoquinone compound for treating and preventing hearing loss.

Description

technical field [0001] The present invention relates to a composition for treating or preventing hearing loss comprising a naphthoquinone based compound. Background technique [0002] The organ of Corti is an auditory epithelium gathered on the basilar membrane of the cochlea (cochlear duct) of the inner ear, which functions through auditory hair cells, the lowest number of sensory receptors of all sensory tissues. Compared to the retina, which has 137,000,000 visual sensory receptor cells, the human cochlea has only 20,000 sensory receptor cells, and mammalian hair cells are only produced during embryonic development and will not regenerate if lost after birth. Therefore, loss of these hair cells causes significant and irreversible hearing loss. [0003] Hearing loss has been found to be primarily due to the death of the hair cells from different causes including: trauma, aging, excessive noise and pollution, ototoxic drugs such as antibiotics (eg gentamicin), the loop of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P27/16
CPCA61K31/39A61K31/38A61K31/381A61K31/382A61K31/352A61K31/343A61P3/02A61P27/16
Inventor 郭泰焕朴明奎苏弘燮朴来佶金亨珍
Owner MAZENCE INC
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