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Application of chymotrypsin preparation in treating oral ulcer

A technology for chymotrypsin and oral ulcers, applied in the field of medicine, can solve problems such as inability to exert curative effect for a long time, loss, and non-film-forming properties

Inactive Publication Date: 2012-10-31
SHANGHAI NATURE STANDARD R&D & BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this kind of enzyme scavenger does not have film-forming properties, and it is easy to lose due to saliva after being used in the oral mucosa, so it cannot exert its curative effect for a long time

Method used

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  • Application of chymotrypsin preparation in treating oral ulcer
  • Application of chymotrypsin preparation in treating oral ulcer
  • Application of chymotrypsin preparation in treating oral ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Measurement method

[0033] Using BAEE (benzoyl arginine ethyl ester) as a substrate, the chymotrypsin activity in different samples was detected at a wavelength of 253 nm by using an ultraviolet spectrophotometer. The calculation is based on the SIGMA standard, and the absorbance value at 60s is taken. Every increase of 0.001ABS in the absorbance value means that the enzyme activity increases by 1U. (BAEE is dissolved in DMSO, and the concentration of BAEE in the 3ml detection system is 0.5mmol / L)

[0034] (2) Determination results: See Table 2.

[0035] The assay result of the enzyme activity of the chymotrypsin ulcer powder of table 2 different enzyme content and carrier

[0036]

[0037] Comparing the enzyme activities of the samples numbered 1-4, with the increase of the enzyme content, the measured value of the enzyme activity also increased, and the enzyme activity of each sample was compared with the chymotrypsin sample, and the enzyme activity retentio...

example 2

[0039] Preparation of Chymotrypsin Powder

[0040]

[0041]

[0042] Preparation Process:

[0043] Mix chymotrypsin, polyaspartic acid, starch, and carbopol evenly, pass through a 60-mesh sieve, add sodium alginate, gum arabic, and sieve after mixing evenly to obtain a powder.

[0044] The chymotrypsin powder was given to 5 volunteers with oral ulcers and applied twice a day. Oral powder without chymotrypsin was given to 4 controls. The results show that the chymotrypsin powder can greatly shorten the healing time of oral ulcer (compared with the control, the healing time is shortened by 20-80%).

example 3

[0046] Preparation of chymotrypsin oral powder with other types of polycarboxyethylene (Karber wave) as the carrier

[0047] Kappa-910, Kappa-934 and Kappa-1342 were used as carriers respectively, and the samples were prepared according to Example 1. The results obtained were consistent with the samples obtained with Kappa-940, all of which had good enzyme activity Retention rate (all greater than 85%), stability and significant curative effect.

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Abstract

The invention relates to an application of a chymotrypsin preparation in treating oral ulcer. According to the invention, the preparation comprises 0.1-30 parts by weight of chymotrypsin and 70-99.9 parts by weight of a solid excipient which is selected from carboxyvinyl polymer (Carbopol), hyaluronic acid, poly(aspartic acid), gum Arabic, citric acid, sodium alginate, acrylic resin, magnesium stearate, starch, or a combination thereof. The oral ulcer preparation is a solid or semi-solid preparation. In the preparation, the content of the raw material chymotrypsin is higher than 95.0%. The preparation can be powder or tablets. The invention also provides a preparation method of the preparation. The oral ulcer preparation provided by the invention is advantaged in simple application, good curative effect, and long action duration.

Description

technical field [0001] The invention relates to the application of chymotrypsin preparation in treating oral ulcer and belongs to the technical field of medicine. Background technique [0002] Oral ulcers are common and frequently-occurring diseases in daily life, and are painful, solitary or recurrent ulcers of the oral mucosa caused by various reasons. The most notable feature of this disease is recurrent attacks. The number of ulcers ranges from few to many, and the sites are from front to back. They are mainly found in the oral mucosa, gums, upper and lower sides of the tongue and throat. The ulcer surface is as big as soybeans and as small as rice grains. There are white erosive rot membranes. In mild cases, the disease may occur once every few months. In severe cases, the interval will gradually shorten and even ulcers will come and go, and will not heal for several years or even decades. [0003] The etiology and pathogenic mechanism of oral ulcer are still unclear. ...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K47/12A61K47/32A61K47/34A61K47/36A61P1/02
Inventor 柴逸峰娄子洋李力李铁军钱勇程萍
Owner SHANGHAI NATURE STANDARD R&D & BIOTECH
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